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posted by martyb on Friday January 12 2018, @12:00PM   Printer-friendly
from the the-end-is-near...-we-hope! dept.

Just a year ago, poliovirus seemed on its last legs in Pakistan, one of its final strongholds. Polio cases were steadily falling, from 306 in 2014 to 54 in 2015, 20 in 2016, and, by last count, eight in 2017. Blood tests showed that, overall, immunity to the virus had never been higher, even among children aged 6 to 11 months, thanks to years of tireless vaccination campaigns. Surely, there were not enough susceptible kids to sustain transmission, and the virus would burn itself out within a year.

Unsettling new findings, however, show it is far from gone. In the most extensive effort in any country to scour the environment for traces of the virus, polio workers are finding it widely across Pakistan, in places they thought it had disappeared. They are wondering "just what the hell is going on" and how worried they should be, says epidemiologist Chris Maher of the World Health Organization (WHO) in Geneva, Switzerland, who runs polio operations in the eastern Mediterranean region. Does this mean the virus is more entrenched than anyone realized and is poised to resurge? Or is this how a virus behaves in its final days—persisting in the environment but not causing disease until it fades out?

[...] Along with Afghanistan and Nigeria, Pakistan is one of just three endemic countries—places where indigenous wild poliovirus has never been vanquished.

[...] Since the eradication effort began in 1988, the gold standard for detecting poliovirus has been surveillance for acute flaccid paralysis (AFP)—finding and testing every child with a sudden weakness or floppiness in the arms or legs. The yearly case count has been the benchmark for success: After 12 months without a polio case, WHO has historically removed a country from the endemic list.

Polio workers collect sewage samples, usually from open drainage ditches, and test them for virus. If the test is positive, that means someone in the catchment area is infected and actively excreting it. Pakistan now has 53 sampling sites, more than any other country. And at a time when cases are the lowest on record, 16% of samples from across the country are testing positive.

[...] One possible explanation for the disconnect is that AFP surveillance is missing cases. Maher doubts that the number is significant, but others suspect that too many children among the mobile populations, including the marginalized Pashtun minority, still aren't being vaccinated despite ramped up efforts to reach them. "I don't think polio is entrenched across Pakistan, but this last reservoir of 'people on the move' is sustaining the virus," says Steve Cochi, a polio expert at the U.S. Centers for Disease Control and Prevention in Atlanta.

[...] The program is not taking any chances. The response to each positive environmental test is now as aggressive as to a case of paralysis. And the program is hammering the virus with repeated vaccination campaigns throughout the "low season," between December and May, when cold weather makes it tougher for the virus to survive. Whether the strategy works will become clear later this year when the weather turns warm. But one thing is certain: The absence of cases is no longer enough to declare victory over polio. Going forward, a country will not be considered polio-free until 12 months have passed without a case—or a positive environmental sample.

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  • (Score: 1) by khallow on Saturday January 13 2018, @04:09AM (2 children)

    by khallow (3766) Subscriber Badge on Saturday January 13 2018, @04:09AM (#621691) Journal

    I remember one story about the Gates Foundation plowing money into vaccination against specific diseases when some local people were begging desperately for funding to deal with the sewage problem. The local pleas were being ignored because it was not what the money was earmarked for -- even though fixing the sewage problem would help prevent all sorts of diseases.

    Apparently, it is exclusively the Gates Foundation's responsibility to listen to people and fix the sewage problem. They don't have infinite resources to fix everything, so it shouldn't be surprising that they don't fix everything. There are numerous other parties slacking on this job, including several levels of government. Further, the Gates Foundation probably was funding one or more of those other glaring oversights with the immunizations.

  • (Score: 0) by Anonymous Coward on Saturday January 13 2018, @04:26PM (1 child)

    by Anonymous Coward on Saturday January 13 2018, @04:26PM (#621837)

    It's the Gates Foundation's responsibility to research the situation and make the most effective use of the money. But vaccinations are high-tech, toilets low-tech and therefore not as sexy. If it was a government program doing this, you'd be apoplectic about how this was going down. So why give the Gates Foundation a pass?

    • (Score: 1) by khallow on Monday January 15 2018, @02:57AM

      by khallow (3766) Subscriber Badge on Monday January 15 2018, @02:57AM (#622384) Journal

      It's the Gates Foundation's responsibility to research the situation and make the most effective use of the money.

      No, it's not their responsibility. And what makes you think they made the wrong choice? Building sewers, toilets, and such is in reach of these communities. These are local problems easily solved at the local level. Immunizing large swaths of humanity is not.

      But vaccinations are high-tech, toilets low-tech and therefore not as sexy.

      And yet, vaccines aren't high-tech or sexy. That is an absurd thing to say. That's why the Gates Foundation ended up funding these things in the first place. Because a lot of others weren't.