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Researchers at Tufts University have elucidated a mechanism by which the "good" bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease.
[...] People who eat a high fat diet are more susceptible to NAFLD. Replicating that diet in mice, the researchers found that within just a few weeks, their intestinal microbiota changed character significantly, with some species of bacteria increasing and others decreasing. At the same time, an inventory of metabolites in the mouse's GI tract, serum and liver showed some metabolites known to be linked to intestinal microbiota to shift compared to mice on a low-fat diet. Three of those metabolites -- tryptamine (TA), indole-3-acetate (I3A), and xanthurenic acid -- were significantly depleted in high fat diet mice.
"That's bad news for the liver," said Kyongbum Lee, Ph.D., professor of chemical and biological engineering at the School of Engineering at Tufts. "We demonstrated that two of these metabolites -- I3A and TA -- attenuate the effects of inflammation in several ways. Their depletion clears the way for disease to progress toward more serious stages."
Smitha Krishnan, Yufang Ding, Nima Saedi, Maria Choi, Gautham V. Sridharan, David H. Sherr, Martin L. Yarmush, Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. Cell Reports, 2018; 23 (4): 1099 DOI: 10.1016/j.celrep.2018.03.109
(Score: 0) by Anonymous Coward on Tuesday May 08 2018, @04:17PM
i doubt it. the people who wrote "People who eat a high fat diet are more susceptible to NAFLD" were not being specific enough. they were undoubtedly meaning a "normal" high fat diet. IOW, a bunch of carbs and sugar and too much fat. ie. the average american diet. they were not talking about keto. the reason that matters is because the whole point of keto is that you don't give the body any other fuel and it has to burn all that extra fat and cholesterol. no way for it to build up to cause fatty liver disease unless your liver doesn't work properly. unless someone can show that doing keto long term is hard on the liver just because it's not meant to be used for that so often, then this is not applicable at all.
since i don't have the testers for cholesterol and ketones, i have moved to a highly plant based diet with a small percent of other foods allowed. those other foods are keto-only. this, i feel, is more than safe until i can prove to myself that keto-only is working as advertised(safety wise). god knows you drop weight like nobody's business. i've lost 56 pounds of fat over the last 6 months.