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posted by chromas on Wednesday March 27 2019, @12:34PM   Printer-friendly
from the vax-papers-please dept.

Emergency Declared in NY over Measles: Unvaccinated Barred from Public Spaces:

Plagued by a tenacious outbreak of measles that began last October, New York's Rockland County declared a state of emergency Tuesday and issued a directive barring unvaccinated children from all public spaces.

Effective at midnight Wednesday, March 27, anyone aged 18 or younger who has not been vaccinated against the measles is prohibited from public spaces in Rockland for 30 days or until they get vaccinated. Public spaces are defined broadly in the directive as any places:

[W]here more than 10 persons are intended to congregate for purposes such as civic, governmental, social, or religious functions, or for recreation or shopping, or for food or drink consumption, or awaiting transportation, or for daycare or educational purposes, or for medical treatment. A place of public assembly shall also include public transportation vehicles, including but not limited to, publicly or privately owned buses or trains...

The directive follows an order from the county last December that barred unvaccinated children from schools that did not reach a minimum of 95 percent vaccination rate. That order—and the directive issued today—are intended to thwart the long-standing outbreak, which has sickened 153 people, mostly children.

What were they waiting for? A pox on them all?


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  • (Score: 3, Informative) by Anonymous Coward on Wednesday March 27 2019, @01:39PM (39 children)

    by Anonymous Coward on Wednesday March 27 2019, @01:39PM (#820618)

    Vaccination rates for confirmed measles cases in Rockland County:

            82.1% have had 0 MMRs
            4.0% have had 1 MMR
            4.0% have had 2 MMRs
            9.9% unknown status

    Age groups for the confirmed measles cases in Rockland County

            Less than 1 year old: 15.0%
            1-3 years: 23.8%
            4-18 years: 45.7%
            19+ years: 15.2%

    So at least 8% of the cases were vaccinated, but the population is ~95% vaccinated. Hmm, if only we could apply some math to figure out how effective the MMR vaccine really is. Nah, this is medicine.

    Starting Score:    0  points
    Moderation   +3  
       Insightful=1, Informative=2, Total=3
    Extra 'Informative' Modifier   0  

    Total Score:   3  
  • (Score: 1, Informative) by Anonymous Coward on Wednesday March 27 2019, @01:59PM (6 children)

    by Anonymous Coward on Wednesday March 27 2019, @01:59PM (#820633)

    How did they even get these numbers? If there are 153 cases 82.1% would be 125.613 children.

    • (Score: 2) by realDonaldTrump on Wednesday March 27 2019, @08:57PM (5 children)

      by realDonaldTrump (6614) on Wednesday March 27 2019, @08:57PM (#820944) Homepage Journal

      It's not 153 Cases like Beth says. It's 155. SPREADING LIKE WILDFIRE!!!!!!!!

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @09:51PM (4 children)

        by Anonymous Coward on Wednesday March 27 2019, @09:51PM (#820978)

        Here are the results for +/- 50 cases:

        > n = 100:200
        > cbind(n, .821*n)
                 n
          [1,] 100  82.100
          [2,] 101  82.921
          [3,] 102  83.742
          [4,] 103  84.563
          [5,] 104  85.384
          [6,] 105  86.205
          [7,] 106  87.026
          [8,] 107  87.847
          [9,] 108  88.668
          [10,] 109  89.489
          [11,] 110  90.310
          [12,] 111  91.131
          [13,] 112  91.952
          [14,] 113  92.773
          [15,] 114  93.594
          [16,] 115  94.415
          [17,] 116  95.236
          [18,] 117  96.057
          [19,] 118  96.878
          [20,] 119  97.699
          [21,] 120  98.520
          [22,] 121  99.341
          [23,] 122 100.162
          [24,] 123 100.983
          [25,] 124 101.804
          [26,] 125 102.625
          [27,] 126 103.446
          [28,] 127 104.267
          [29,] 128 105.088
          [30,] 129 105.909
          [31,] 130 106.730
          [32,] 131 107.551
          [33,] 132 108.372
          [34,] 133 109.193
          [35,] 134 110.014
          [36,] 135 110.835
          [37,] 136 111.656
          [38,] 137 112.477
          [39,] 138 113.298
          [40,] 139 114.119
          [41,] 140 114.940
          [42,] 141 115.761
          [43,] 142 116.582
          [44,] 143 117.403
          [45,] 144 118.224
          [46,] 145 119.045
          [47,] 146 119.866
          [48,] 147 120.687
          [49,] 148 121.508
          [50,] 149 122.329
          [51,] 150 123.150
          [52,] 151 123.971
          [53,] 152 124.792
          [54,] 153 125.613
          [55,] 154 126.434
          [56,] 155 127.255
          [57,] 156 128.076
          [58,] 157 128.897
          [59,] 158 129.718
          [60,] 159 130.539
          [61,] 160 131.360
          [62,] 161 132.181
          [63,] 162 133.002
          [64,] 163 133.823
          [65,] 164 134.644
          [66,] 165 135.465
          [67,] 166 136.286
          [68,] 167 137.107
          [69,] 168 137.928
          [70,] 169 138.749
          [71,] 170 139.570
          [72,] 171 140.391
          [73,] 172 141.212
          [74,] 173 142.033
          [75,] 174 142.854
          [76,] 175 143.675
          [77,] 176 144.496
          [78,] 177 145.317
          [79,] 178 146.138
          [80,] 179 146.959
          [81,] 180 147.780
          [82,] 181 148.601
          [83,] 182 149.422
          [84,] 183 150.243
          [85,] 184 151.064
          [86,] 185 151.885
          [87,] 186 152.706
          [88,] 187 153.527
          [89,] 188 154.348
          [90,] 189 155.169
          [91,] 190 155.990
          [92,] 191 156.811
          [93,] 192 157.632
          [94,] 193 158.453
          [95,] 194 159.274
          [96,] 195 160.095
          [97,] 196 160.916
          [98,] 197 161.737
          [99,] 198 162.558
        [100,] 199 163.379
        [101,] 200 164.200

        • (Score: 2) by realDonaldTrump on Wednesday March 27 2019, @10:13PM (3 children)

          by realDonaldTrump (6614) on Wednesday March 27 2019, @10:13PM (#820995) Homepage Journal

          Beautiful spreadsheet, great job but they're not saying 82.1% right now. They're saying 82.6% and they're saying 155 cases. That's the latest from the D.O.H., the Department of Health. Not from Beth Mole. And I think that one works out O.K. Unlike what Beth put, what she has in her article.

          • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @10:35PM (2 children)

            by Anonymous Coward on Wednesday March 27 2019, @10:35PM (#821008)

            Beautiful spreadsheet, great job but they're not saying 82.1% right now. They're saying 82.6% and they're saying 155 cases.

            Well where did 82.1 come from? That was a direct copy/paste.

            • (Score: 2) by realDonaldTrump on Wednesday March 27 2019, @11:10PM (1 child)

              by realDonaldTrump (6614) on Wednesday March 27 2019, @11:10PM (#821025) Homepage Journal

              The 82.1% isn't from Beth, it's not in her article. Ammonyous tweeted it and that, I assume, is where I saw it. The 153 is in her article. D.O.H., right now is saying 155. And, they're saying 82.6%. Possibly they said 82.1% before, and possibly they said 153 -- who knows? Sorry Beth, I'll make it up to you. As only a man can do!

              • (Score: 1, Funny) by Anonymous Coward on Wednesday March 27 2019, @11:17PM

                by Anonymous Coward on Wednesday March 27 2019, @11:17PM (#821028)

                I quoted that number accurately, I'll stake my reputation on it. Wayback machine it.

  • (Score: 3, Informative) by Anonymous Coward on Wednesday March 27 2019, @02:37PM (8 children)

    by Anonymous Coward on Wednesday March 27 2019, @02:37PM (#820660)

    More data:

    Common Complications include ear infections and diarrhea.

            Ear infections occur in about one out of every 10 children with measles and can result in permanent hearing loss.
            Diarrhea is reported in less than one out of 10 people with measles.

    Severe Complications

    Some people may suffer from severe complications, such as pneumonia (infection of the lungs) and encephalitis (swelling of the brain). They may need to be hospitalized and could die. Here are some facts about complications in children and pregnant women:

            As many as one out of every 20 children with measles gets pneumonia, the most common cause of death from measles in young children.
            About one child out of every 1,000 who get measles will develop encephalitis (swelling of the brain) that can lead to convulsions and can leave the child deaf or with intellectual disability.
            For every 1,000 children who get measles, one or two will die from it.
            Measles may cause pregnant woman to give birth prematurely, or have a low-birth-weight baby.

    http://rocklandgov.com/departments/health/measles-information/ [rocklandgov.com]

    Not sure where they are getting these numbers from. Mine are:

    One of the major sources of doubt about the need for immunization stems from the belief among many parents and doctors that measles is a mild disease in which serious complications are rare and almost never fatal in normal children.
    [...]
    Neary 67 per 1,000, or about 1 in every 15 persons with measles in this survey, suffered from at least one complication. The most numerous were severe affections of the respiratory tract (38 per 1,000) and otitis media (25 per 1,000), followed by neurological disturbances (4 per 1,000) and a small number of others (2 per 1,000). Twelve of the children studied (0.2 per 1,000) are known to have died after measles, and 610 (11.5 per 1,000) were admitted to hospitals as a direct result of the disease.
    [...]
    Encephalitis or impaired consciousness was reported in one per 1,000,

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815949/ [nih.gov]

    So their (unsourced) estimate of the complications are pretty close, but 2-5x too high for some issues.

    Compare to the side effects of MMR (from ~1500 children):

    The incidence of fever reported as solicited general symptom during the 43-day post-vaccination period was also similar between groups, with 31.1% of MMR-RIT and 32.3% of MMR II-vaccinated children reporting fever ≥ 38.0°C, and 4.0% and 2.7% reporting grade 3 fever (> 39.5°C) (Figure 2 and Supplemental table S1). Medical advice for fever was sought for 13.1% and 10.1% of children in the MMR-RIT and MMR II groups, respectively.
    [...]
    Febrile convulsions were reported for two (0.2%) MMR-RIT-vaccinated children.
    [...]
    Rashes were reported for 24.4% of MMR-RIT and 27.4% of MMR II-vaccinated children. Approximately two thirds of the rashes were localized and occurred without fever. Measles/rubella-like rashes were reported for 5.8% and 4.7% of children; varicella-like rashes (as a possible consequence of the co-administered varicella vaccine) for 3.6% and 4.0% (Table 3). Medical advice for rashes was sought for 11.2% and 12.4% of children in the MMR-RIT and MMR II groups, respectively.
    [...]
    A total of 51.4% (95% CI: 48.5%, 54.3%) and 48.4% (44.3%, 52.6%) of children in the MMR-RIT and MMR II groups, respectively, reported unsolicited adverse events (AEs) during the 43-day post-vaccination period; upper respiratory tract infection (9.5% and 12.8%) and diarrhea (8.2% and 8.0%) occurred most frequently.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343620/ [nih.gov]

    Ear Infections:
    Them = 0.1
    Miller = 0.025
    MMR  < 0.0007? (not mentioned)

    Pneumonia:
    Them = 0.05
    Miller  = 0.038
    MMR = 0.1

    Encephalitis:
    Them = 0.001
    Miller = 0.001
    MMR  < 0.0007? (febrile convulsions = .002)

    Mortality:
    Them = 0.001
    Miller = 0.0002
    MMR  < 0.0007

    Fever:
    Them ~ 1.0 (assumed)
    Miller ~ 1.0 (assumed)
    MMR  = 0.3

    Rash:
    Them ~ 1.0 (assumed)
    Miller ~ 1.0 (assumed)
    MMR  = 0.25

    And I wonder about the 100% of cases had a fever and rash assumption since pre-vaccine only ~15% of measles cases ever got reported. It would make sense if those were the most extreme/classic cases.

    • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:03PM

      by Anonymous Coward on Wednesday March 27 2019, @03:03PM (#820678)

      Found ear infections after MMR:

      (acute) otitis media (MMR-RIT: 23 children, 1.9%; MMR II: 9 children, 1.5%)

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343620/ [nih.gov]

      Ear Infections:
      Them = 0.1
      Miller = 0.025
      MMR  = 0.015

    • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:17PM (3 children)

      by Anonymous Coward on Wednesday March 27 2019, @03:17PM (#820688)

      Wow, just comparing data from the medical literature and a lay medical site is "trolling" now.

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:32PM

        by Anonymous Coward on Wednesday March 27 2019, @03:32PM (#820695)

        Yeah, I was thinking the exact same thing. Maybe someone just hit the wrong button when doing their mod?

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @05:04PM (1 child)

        by Anonymous Coward on Wednesday March 27 2019, @05:04PM (#820766)

        you must be new here. just mentioning thruths that are inconvenient to what these idiots think is counterculture (actually programmed into their slave brains by the establishment) is routinely modded as trolling.

        • (Score: 0) by Anonymous Coward on Thursday March 28 2019, @01:16AM

          by Anonymous Coward on Thursday March 28 2019, @01:16AM (#821083)

          just mentioning thruths that are inconvenient to what these idiots think is counterculture (actually programmed into their slave brains by the establishment) is routinely modded as trolling.

          Which is, frankly, why I don't like this system of up/down modding comments her on SN (or that green site). If someone (dis)agrees with someone else's comment I would much rather they tell us why they (dis)agree along with giving us (hopefully) cogent arguments to bolster their case. With the modding of comments you too frequently have a bunch of dittoheads coming through to give us their pretty much useless opinions on the comments of others. Just my take.

    • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @05:22PM (1 child)

      by Anonymous Coward on Wednesday March 27 2019, @05:22PM (#820782)

      The source for the first seems to be the slide set from CDC, it seems to have the same numbers.

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @07:01PM

        by Anonymous Coward on Wednesday March 27 2019, @07:01PM (#820877)

        Where did the CDC get them? Can they be traced back to a specific dataset?

    • (Score: 2) by Reziac on Thursday March 28 2019, @06:02AM

      by Reziac (2489) on Thursday March 28 2019, @06:02AM (#821196) Homepage

      There's also a sort of post-measles syndrome that causes the immune system to do a complete shutdown and reset, almost like short-term AIDS. So until either re-exposed or revaccinated, the post-measles patient is once again vulnerable to all sorts of "childhood diseases", even if they previously had good immunity.

      [Too lazy to look up the source again but was from good research, and rather alarming.]

      --
      And there is no Alkibiades to come back and save us from ourselves.
  • (Score: 5, Touché) by FatPhil on Wednesday March 27 2019, @02:51PM (5 children)

    by FatPhil (863) <reversethis-{if.fdsa} {ta} {tnelyos-cp}> on Wednesday March 27 2019, @02:51PM (#820672) Homepage
    The correct regime, at least in all countries I know of, is 2 vaccinations, one as a baby and one as a kid. If you didn't do 2, then you're not properly vaccinated. So you can only claim 4% were claimed to be properly vaccinated, not 8%. And you've not defined exactly what population you think is "the" population - I suspect you're chosing an irrelevant population for means of sophistry.

    Your gibbering is so mathemeatically incoherent, I honestly can't work out what actual point you're trying to make. The fact that the only bit I could work out was just plain wrong (at least in all countries I know of) doesn't give me much faith there is a coherent argument anywhere.
    --
    Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
    • (Score: -1, Troll) by Anonymous Coward on Wednesday March 27 2019, @03:09PM (3 children)

      by Anonymous Coward on Wednesday March 27 2019, @03:09PM (#820683)

      So you can only claim 4% were claimed to be properly vaccinated, not 8%.

      Depends on the age of the child. During the interim the child is "properly" vaccinated. In the future "properly vaccinated" will likely mean three vaccinations btw, as the weaker antibodies begin to wane from the vaccinated generation.

      And you've not defined exactly what population you think is "the" population - I suspect you're chosing an irrelevant population for means of sophistry.

      I am not choosing any population. Where do you see me seem to choose one? They do not share that data with us.

      Your gibbering is so mathemeatically incoherent, I honestly can't work out what actual point you're trying to make.

      Well if you see me "choosing populations" when I did no such thing I can see why you would think it was incoherent. But that problem lies with you making stuff up.

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:12PM

        by Anonymous Coward on Wednesday March 27 2019, @03:12PM (#820685)

        typo:

        Well if you see me "choosing populations"? When I did no such thing, I can see why you would think it was incoherent.

      • (Score: 2) by FatPhil on Thursday March 28 2019, @12:17AM (1 child)

        by FatPhil (863) <reversethis-{if.fdsa} {ta} {tnelyos-cp}> on Thursday March 28 2019, @12:17AM (#821061) Homepage
        You did chose a population, as there were clearly 2 possibilities. One was relevant, one was irrelevant, and I'm guessing you chose the irrelevant one.

        Lack of actual response argument, apart from flailing wildly, noted.
        --
        Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
        • (Score: 0) by Anonymous Coward on Thursday March 28 2019, @12:35AM

          by Anonymous Coward on Thursday March 28 2019, @12:35AM (#821072)

          No, I really do not know how many students are in these schools who were "exposed". They chose to not tell us that for whatever reason.

    • (Score: 0) by Anonymous Coward on Thursday March 28 2019, @03:45AM

      by Anonymous Coward on Thursday March 28 2019, @03:45AM (#821151)

      Read the MMR vaccine insert. The vaccine only provides temporary protection. If you want to be "fully" vaccinated you need to keep having the vaccine every few years.
      Read the MMR vaccine insert. It's only effective in ~70% of people.

  • (Score: 2) by ilsa on Wednesday March 27 2019, @03:35PM (5 children)

    by ilsa (6082) Subscriber Badge on Wednesday March 27 2019, @03:35PM (#820698)

    Ok I've read your post 3 times and I still can't figure out what point you think you're making. According to the very stats you posted, only 4% of the population is properly vaccinated.

    I can't even guess as to how you got " the population is ~95% vaccinated."

    Considering that you posted AC, I'm guessing you're just another troll, but a particularly inept one.

    • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:56PM (2 children)

      by Anonymous Coward on Wednesday March 27 2019, @03:56PM (#820711)

      different AC, but -

      4% of the INFECTED are fully vaccinated (suggesting ~95% efficacy)

      ~95% TOTAL POPULATION are fully vaccinated.

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @06:11PM

        by Anonymous Coward on Wednesday March 27 2019, @06:11PM (#820832)

        I don't know how you came up with that "suggesting 95% efficacy", it seems completely bogus mathematics.
        You cannot calculate the efficacy from the given numbers.
        If we normalize the number of infected to 100 (with 4 being vaccinated) and assume that a fraction "f" of the population came in contact with the virus, equally between vaccinated and unvaccinated (unlikely, but we need some assumptions at least).
        Then the total population "t" must be at least t >= 96/f (here already we have an error, some of those not vaccinated will be immune).
        Now we have a vaccination rate "r", which for this area is UNKNOWN.
        The number of vaccinated would thus be t*r >= (96/f)*r.
        Applying the exposure fraction "f" to get those vaccinated and exposed would be >= 96*r.
        As of those 4 got sick, so 4/(96*r) is the fraction of those vaccinated and exposed who got sick.
        Which means efficacy of the vaccine would come out at 1 - 4/(96*r).
        If you A PRIORY assume 95% vaccination rate, that would give a > 96% efficacy of the vaccination.
        However it would be quite possible that half of those not vaccinated were already immune, in which case you would come out with a > 98% efficacy.
        Or you could assume that those vaccinated belong to a different social circle and are less likely to be exposed, and then you get a lower efficacy.
        So without clear data on the number of vaccinated people with exposure you can't calculate how effective the vaccination was.

      • (Score: 2) by sjames on Thursday March 28 2019, @04:22AM

        by sjames (2882) on Thursday March 28 2019, @04:22AM (#821167) Journal

        Actually the only thing it suggests is that the vaccine is not 100% effective (we already knew that). You would need to know how many fully vaccinated were exposed to measles and how many un-vaccinated were exposed to compute the effectiveness of the vaccine.

    • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @03:57PM

      by Anonymous Coward on Wednesday March 27 2019, @03:57PM (#820713)

      I can't even guess as to how you got " the population is ~95% vaccinated."

      It says in the summary they target 95% vaccination rates. I took that as a rough estimate:

      The directive follows an order from the county last December that barred unvaccinated children from schools that did not reach a minimum of 95 percent vaccination rate

    • (Score: 2) by cmdrklarg on Wednesday March 27 2019, @04:27PM

      by cmdrklarg (5048) Subscriber Badge on Wednesday March 27 2019, @04:27PM (#820737)

      I am reading it as:

      For the *confirmed cases*, there were only 4% that had the proper vaccinations.

      --
      Answer now is don't give in; aim for a new tomorrow.
  • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @05:29PM (10 children)

    by Anonymous Coward on Wednesday March 27 2019, @05:29PM (#820786)

    Uh, that math is well known. The effectiveness of the vaccine is such that 1 vaccination is not sufficient to achieve herd immunity even if everyone was vaccinated.
    Thus the need for 2 vaccinations, which with a > 96% (I think) vaccination rate in the population allows for herd immunity.
    That is the reason why those exceptions are a MAJOR issue in cases of measles.
    Btw. even if the vaccine had significant side effects, this would still at best be a "tragedy of the commons" case. With enough people being vaccinated we could eradicate measles like we did for other humans-only sicknesses, which means the anti-vaccination people could then live happily ever after. We'd just need to make the sacrifice ONCE, world-wide.
    Instead it looks like we might be stuck with the suffering measles causes for all eternity. Millions and millions of dead people for essentially no reason. Can we call those refusing vaccinations mass murderers? (no, not really serious, but anyone refusing measles vaccination for themselves or their children is really, really VERY far from any moral high road)

    • (Score: 1, Interesting) by Anonymous Coward on Wednesday March 27 2019, @06:11PM (8 children)

      by Anonymous Coward on Wednesday March 27 2019, @06:11PM (#820831)

      Two vaccines are also clearly insufficient for herd immunity. If there was herd immunity the virus would die out.

      With enough people being vaccinated we could eradicate measles like we did for other humans-only sicknesses

      Yes, this was the original goal of measles vaccinations. They didn't believe that measles could survive long in the air at the time so thought it would be much easier.

      The Center for Disease Control (CDC) led in mounting the program with a formal paper at the American Public Health Association annual meeting in Miami in the fall of 1966. Two colleagues and I wrote the “official statement” which outlined in detail unqualified statements about the epidemiology of measles and made an unqualified prediction. My third position in the authorship of this paper did not adequately reflect my contribution to the work.14 I will make but two quotes:
                      1. “The infection spreads by direct contact from person to person, and by the airborne route among susceptibles congregated in enclosed spaces.” (Obviously the ideas of Perkins and Wells had penetrated my consciousness but not sufficiently to influence my judgment). 2. “Effective use of (measles) vaccines during the coming winter and spring should insure the eradication of measles from the United States in 1967.” Such was my faith in the broad acceptance of the vaccine by the public and the health professions and in the infallibility of herd immunity.
              [...]
              There are many reasons and explanations for this rather egregious blunder in prediction. The simple truth is that the prediction was based on confidence in the Reed-Frost epidemic theory, in the applicability of herd immunity on a general basis, and that measles cases were uniformly infectious. I am sure I extended the teachings of my preceptors beyond the limits that they had intended during my student days.

              In the relentless light of the well-focussed retrospectiscope, the real failure was our neglect of conducting continuous and sufficiently sophisticated epidemiological field studies of measles. We accepted the doctrines imbued into us as students wikout maintaining the eternal skepticism of the true scientist.
              [...]
              Clearly we must revise our theory and recognize that these outbreaks must be airborne in character involving exposure to aerosols presumably created by the rare super-spreader who contaminates a large populated enclosed space such as a school auditorium or gymnasium. These have happened sufficiently often to prove the far sightedness of Perkins and Wells when the rest of us were smugly secure in our epidemic theories, our traditional faith in contact infection and herd immunity.

      https://www.ncbi.nlm.nih.gov/pubmed/6939399 [nih.gov]

      Soon after it was realized that the failure to eradicate meant people needed to pay for vaccines in perpetuity:

      Campaigns such as the one described have altered the epidemiology of measles. No longer will the disease contribute as much to maintaining herd immunity. The prevention of measles epidemics will now require constant maintenance immunization programs.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1228954/ [nih.gov]

      But by the 1980s it was realized that actually "near eradication" is the worst possible thing you can do since it lets susceptibles build up until a massive epidemic gets triggered:

      The second scenario represents the impact of a vaccination programme that reaches high levels of coverage (85% of all new-borns) which are, nevertheless, not high enough to lead to eradication of the agent. However, for the first 15 years after the introduction of vaccination, it appears as if eradication has been achieved, there are no infections. Then, suddenly, a new epidemic appears as if from nowhere. This is an illustration of a phenomenon known as the ‘honeymoon period’. This is the period of very low incidence that immediately follows the introduction of a non-eradicating mass vaccination policy. This happens because susceptible individuals accumulate much more slowly in a vaccinated community. Such patterns were predicted using mathematical models in the 1980s6 and have since been observed in communities in Asia, Africa and South America7. Honeymoon periods are only predicted to occur when the newly introduced vaccination programme has coverage close to the eradication threshold.

      http://www.ncbi.nlm.nih.gov/pubmed/12176860 [nih.gov]

      These tiny outbreaks are probably good in the long run actually, like a small release of pressure instead of a big explosion.

      • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @06:54PM (7 children)

        by Anonymous Coward on Wednesday March 27 2019, @06:54PM (#820864)

        I don't know where you get the claim that 2 vaccinations are not enough from.
        Of course you can't get herd immunity from vaccinating 1 single person.
        You need about 95% to 98% vaccination rate.
        Which no doubt makes eradication hard.
        The article you quoted is not really relevant, that was about "eradication" in the US only.
        That was never going to work.
        It needs to be world-wide.
        Yes, that would need large scale and possibly non-voluntary vaccinations.
        Yes, that would mean not being able to travel to or from certain countries unless you are vaccinated.
        This might sound extreme, but 100s of thousands of deaths world wide are pretty harsh, too.
        The response to measles and lack of true eradication efforts is completely out of whack compared to the disease's immense human cost.

        • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @07:17PM (6 children)

          by Anonymous Coward on Wednesday March 27 2019, @07:17PM (#820885)

          I don't know where you get the claim that 2 vaccinations are not enough from.

          Because the "herd" obviously is not "immune". Like many things having to do with vaccines, the definition of "herd immunity" has weakened to mean something vague like "virus spreads less". It is supposed to mean literally that the virus does not spread and is eradicated (another term that has been weakened).

          You need about 95% to 98% vaccination rate.

          This would be true if the population was "well-mixed" (everyone had equal chance of meeting everyone else). Otherwise, it depends.

          The article you quoted is not really relevant, that was about "eradication" in the US only.
          That was never going to work.

          You are basically saying measles vaccination campaign was based on lies then, because most people didn't care about measles but they sold it as the "end measles campaign":
          http://digitalcollections.archives.nysed.gov/index.php/Detail/Object/Show/object_id/10232 [nysed.gov]

          Personally, I do believe they thought it would work.

          • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @08:36PM (5 children)

            by Anonymous Coward on Wednesday March 27 2019, @08:36PM (#820924)

            > Because the "herd" obviously is not "immune"

            Because we can't achieve the required vaccination rates!

            > the definition of "herd immunity" has weakened to mean something vague like "virus spreads less".

            As far as I know it still means "statistically an infection introduced will die out". It doesn't mean that nobody will get sick if you continue to introduce the virus from outside again and again!

            I'll grant you that the required vaccination rate needed certainly depends on how many people the virus can effect, and there certainly is a risk that if this number increases the virus might not be controllable. However the fact that the virus has stayed confined to communities with low vaccination rates suggests that that is not actually the case so far.

            > You are basically saying measles vaccination campaign was based on lies then, because most people didn't care about measles but they sold it as the "end measles campaign"

            I can't tell from a 3 word slogan what they meant. But if you go back to the 60s I should probably amend it to "it was never going to work with the massive amounts of long-distance and international travel to regions where measles is epidemic and in a world where you do not need to have your vaccination pass to travel".
            I would also add that many years ago there was the ambition of spreading vaccinations world-wide so that it would be eradicated world wide. But instead of in one go the idea was to go continent by continent. That has failed because America and Europe are now backsliding faster than India or Africa make progress on measles vaccination (and as said, 0 effort on preventing re-introduction of measles from affected countries).
            "Nobody gives a shit" is the most accure description of why measles eradication is failing for now. I will though admit it is not a CERTAINTY that complete elimination is possible at all, but I don't see hard evidence it is not possible either.

            • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @08:45PM (4 children)

              by Anonymous Coward on Wednesday March 27 2019, @08:45PM (#820930)

              I can't tell from a 3 word slogan what they meant.

              You do not need to tell from a 3 word quote. I shared a quote from the guy responsible at the CDC (Alexander Langmuir) apologizing for it above.

              • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @09:25PM (3 children)

                by Anonymous Coward on Wednesday March 27 2019, @09:25PM (#820973)

                Full article seems to be paid, but your quotes don't really say whether they expected to have measles disappear forever from the US just by vaccinating everyone inside the US for a few years and then stopping.
                The specific parts you quote seem to be around the heavily underestimated infectiousness of measles.
                That underestimation is the reason why people like me only got 1 dose of vaccine back in the 80s.
                The 2 dose regime to my knowledge is sufficient to compensate for that.
                But I don't see how that would have changed the situation that as long as the measles virus exists anywhere in the world you simply cannot stop vaccinating in the US, that would be a horribly irresponsible idea! I do not know for sure, but I really can't imagine that anyone ever imagined that.
                As said, to my knowledge the plan was to extend vaccination until the whole world was covered and the virus eradicated. A plan which is under threat of completely falling apart due to the combination of anti-vaccination sentiments in America and Europe on the one hand and lack of progress in e.g. Africa and Asia on the other hand.

                • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @09:58PM (2 children)

                  by Anonymous Coward on Wednesday March 27 2019, @09:58PM (#820983)

                  Full article seems to be paid

                  From here you can get the DOI: https://www.ncbi.nlm.nih.gov/pubmed/6939399 [nih.gov]

                  Then paste it in like this: https://sci-hub.tw/10.1111/j.1749-6632.1980.tb18903.x [sci-hub.tw]

                  The domain changes every now and then... just google it. You also may be able to use the pubmed ID, but I use an addon that redirects the DOI links.

                  • (Score: 0) by Anonymous Coward on Wednesday March 27 2019, @11:38PM (1 child)

                    by Anonymous Coward on Wednesday March 27 2019, @11:38PM (#821040)

                    The paper mixes wrong assumptions and corrections wildly, so it's hard to make short convincing quotes

                    > If the immunity were steadily maintained at such a high level, no measles epidemic could arise.

                    This was a statement related to the original theory. I think it shows what I said: the assumption was from the start a high level of immunity via vaccination would be required for a prolonged time.

                    > Intrinsic in my personal thinking was the mistaken belief that once measles was eliminated from a community its reintroduction and beginning spread would lead to a spontaneous community response to immunize all susceptibles in the immediate vicinity and thus promptly snuff out the disease.

                    And at least here, too low vaccination rates are put up as a prime cause (though on this there seems no consistent line).

                    > Incidence further dropped to 50,000 in 1967 and to 25,000 in 1968 but since then has continued a fluctuating course

                    Going by this quote, where the author comes from is that incidents in the 10000s mean a failure of the eradication program. By that standard, measles is still eradicated in the US.

                    And going back to an earlier quote:
                    > An introduction From outside would possibly lead to a sputtering outbreak for a few generations but an epidemic could not ensue
                    The original plan actually anticipated the desired state to include occasional multi-generation outbreaks!

                    > It is clear however that airborne infection is sufficiently common and important to be a determining factor in the continuance of measles at the present time. It must receive due respect and weight in planning the future steps necessary for eradication.

                    I would claim that has been done, by raising the goals to something like 95% immune people (which I think actually means 98% of people being vaccinated twice).
                    I do not see a failure in the plan so far, only in the failure to enact it.

                    In the end, the paper was about the theory of how the diseases spread being utterly un-sound, the mathematics unreasonably simplified etc.
                    However the statistical behaviour that sufficient immunity will limit the spread of the disease and if global eliminate it has not been shown wrong.
                    And the practical results I also think still indicate that sufficient immunity via vaccinations is indeed achievable, though possibly not on voluntary basis. And with the current ambition level clearly not world-wide.

                    • (Score: 0) by Anonymous Coward on Thursday March 28 2019, @03:32AM

                      by Anonymous Coward on Thursday March 28 2019, @03:32AM (#821145)

                      The paper mixes wrong assumptions and corrections wildly, so it's hard to make short convincing quotes

                      Welcome to the real world where no one knows what they are doing. The only question is whether you are on the side of popular people who don't know what they are doing telling you what to do or not.

    • (Score: 2) by realDonaldTrump on Wednesday March 27 2019, @08:48PM

      by realDonaldTrump (6614) on Wednesday March 27 2019, @08:48PM (#820931) Homepage Journal

      Can we call it murder when nobody dies? Very rare for somebody to die from the measles. And I'm sure if it happens, Beth Mole will tell us -- as loudly as possible.

      And, you say, "oh let's Eradicate measles like we did for so many other diseases!" I don't think so. I don't think so. Eradicate, I think, is it's gone. Nobody catching it. Nobody having it. And they're so proud that they did that with smallpox. Something that, by the way, took 200 years. Congratulations on the smallpox but, what else? That's the only one they say, eradicated. You say diseases, it's not diseases, it's one disease.