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Gaaark I'm sad to hear your wife and you are going through this. Hopefully you have helpful supportive family and friends.

Leukemia is complex, almost a set of diseases. The disease and symptoms manifest in many different ways depending on the myriad factors in the patient's health, body chemistry, etc. I hope you're getting top quality care? I assume she's had conventional chemo and radiation? Have you looked into the targeted therapies where they look at genetic markers? Biologics?? Stem cell transplant therapy???

Keytruda (pembrolizumab) might really help her. For some people / cancers, it's showing the best improvement and outcomes.

Neulasta can help, but I'm not sure if it would be right for her though- it can cause white cell count to go Hyperleukocytosis; she'd have to be closely monitored, and it might not be worth the risk, but I know people who have survived cancer and Neulast was part of the treatment program.

I'm sure you've seen it, but https://www.mayoclinic.org/diseases-conditions/leukemia/diagnosis-treatment/drc-20374378 [mayoclinic.org]

And https://www.neupogenhcp.com/acute-myeloid-leukemia/ [neupogenhcp.com]

Not sure where you are in the world, but maybe you've seen this: https://health.usnews.com/best-hospitals/rankings/cancer [usnews.com]

And: https://www.topmastersinhealthcare.com/30-most-technologically-advanced-cancer-centers-in-the-world/ [topmastersinhealthcare.com]