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posted by martyb on Tuesday March 03 2020, @05:42PM   Printer-friendly
from the How-old-is-Betteridge? dept.

Is Aging a Disease?

Whether ageing can be cured or not, there are arguments for thinking about it like a disease. But there are major pitfalls, too.

The first depiction of humanity's obsession with curing death is The Epic of Gilgamesh—which, dating back to at least 1800 B.C., is also one of the first recorded works of literature, period. Centuries later, the ancient Roman playwright Terentius declared, "Old age itself is a sickness," and Cicero argued "we must struggle against [old age], as against a disease." In 450 B.C., Herodotus wrote about the fountain of youth, a restorative spring that reverses aging and inspired explorers such as Ponce de León. But what once was a mythical holy grail is now seemingly within tantalizing reach. As humans' understanding and knowledge of science and technology have increased, so too have our life spans.

[...] Maybe the ancients weren't wrong, and aging can be not only delayed but cured like a disease. Over the years, the movement to classify aging as a disease has gained momentum not only from longevity enthusiasts but also from scientists. In 1954, Robert M. Perlman published a paper in the Journal of American Geriatrics Society called "The Aging Syndrome" in which he called aging a "disease complex." Since then, others have jumped on board, including gerontologists frustrated by a lack of funding to study the aging process itself.

[...] However, labeling aging itself as a disease is both misleading and detrimental. Pathologizing a universal process makes it seem toxic. In our youth-obsessed society, ageism already runs rampant in Hollywood, the job market, and even presidential races. And calling aging a disease doesn't address critical questions about why we age in the first place. Instead of calling aging a disease, scientists should aim to identify and treat the underlying processes that cause aging and age-related cellular deterioration.

Medical understanding of that cellular deterioration began in 1962, when Leonard Hayflick, professor of anatomy at the University of California San Francisco School of Medicine, made fundamental breakthroughs to understanding aging: He discovered a limit to how many times typical human cells divide before they become senescent, or exhausted. Before then, scientists had assumed human cells were immortal. Hayflick also figured out that telomeres, which cap the ends of chromosomes and prevent them from fraying, much like plastic tips preserve the ends of shoelaces, shorten each time a cell divides. When the telomeres get short enough, a cell stops dividing.

[...] Many gerontologists distinguish between "health span" and "life span," the length of time someone enjoys relative good health versus the length of someone's life. Longevity while in poor health, pain, or with limitations that sap quality of life makes little sense. Fleming urges "regulators and public policy makers to embrace healthspan as an organizing focus for facilitating the development of medicine that target aging and chronic diseases." This shift would promote research on disease-causing processes, which could help us prevent more age-related diseases, not just manage them.

As gerontologists Sean Leng and Brian Kennedy put it, "Aging is the climate change of health care." The Population Reference Bureau predicts that 100 million Americans will be 65 or older by 2060. How will we care for this population? It's daunting to think about one's own aging, let alone the 16 percent of the world's population who will be seniors[sic] citizens by midcentury. A big-picture approach focused on the processes of aging—processes we share with nearly all living organisms—will put us on a path not only to longer lives but to healthier ones.


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  • (Score: 0, Funny) by Anonymous Coward on Tuesday March 03 2020, @06:05PM (23 children)

    by Anonymous Coward on Tuesday March 03 2020, @06:05PM (#966060)

    It will eventually get rid of boomers, none too soon.

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  • (Score: 5, Touché) by Anonymous Coward on Tuesday March 03 2020, @06:16PM (5 children)

    by Anonymous Coward on Tuesday March 03 2020, @06:16PM (#966065)

    Whose basement will you live in then?

    • (Score: 2) by DannyB on Tuesday March 03 2020, @07:49PM (4 children)

      by DannyB (5839) Subscriber Badge on Tuesday March 03 2020, @07:49PM (#966111) Journal

      Inherit the basement. At least that would be my hope, rather than be left homeless.

      --
      If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious
      • (Score: 2) by FatPhil on Tuesday March 03 2020, @09:25PM (3 children)

        by FatPhil (863) <{pc-soylent} {at} {asdf.fi}> on Tuesday March 03 2020, @09:25PM (#966163) Homepage
        Sorry, the procedes from its sale have been left to the cats' shelter - she always liked cats more than you!
        --
        Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
        • (Score: 2) by DannyB on Tuesday March 03 2020, @09:50PM (2 children)

          by DannyB (5839) Subscriber Badge on Tuesday March 03 2020, @09:50PM (#966175) Journal

          I don't live in a basement. I was expressing my hope that one who does dwell in the basement, might at least inherit it. But you may have a point.

          --
          If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious
          • (Score: 1) by khallow on Wednesday March 04 2020, @07:27PM (1 child)

            by khallow (3766) Subscriber Badge on Wednesday March 04 2020, @07:27PM (#966644) Journal
            So you've already been kicked out of the basement by the cats? Sad.
            • (Score: 2) by DannyB on Wednesday March 04 2020, @09:41PM

              by DannyB (5839) Subscriber Badge on Wednesday March 04 2020, @09:41PM (#966710) Journal

              That would be sad. Especially if the cats had overrun the house.

              But I'm allergic to cats. We have only one dog now.

              --
              If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious
  • (Score: 4, Insightful) by Hartree on Tuesday March 03 2020, @06:24PM (10 children)

    by Hartree (195) on Tuesday March 03 2020, @06:24PM (#966071)

    "It will eventually get rid of boomers, none too soon."

    Yes, but we may get you first.

    Never underestimate old age and treachery!

    • (Score: 1, Funny) by Anonymous Coward on Tuesday March 03 2020, @08:28PM (9 children)

      by Anonymous Coward on Tuesday March 03 2020, @08:28PM (#966132)

      If I may speak as a representative of GenX, we've been warning the Millennials that the Boomers will not go quietly. But nobody ever listens... (shrug).

      • (Score: 2) by Bot on Tuesday March 03 2020, @10:20PM (8 children)

        by Bot (3902) on Tuesday March 03 2020, @10:20PM (#966193) Journal

        I dunno where you live, but boomers here in Italy have actually been defrauded of their pension funds (which BTW were institute by a socialist welfare maniac called Benito Mussolini probably with the long term intention of destroying family as a unit in favor of the state). So whenever somebody complains of boomers sucking pensions from the state I say: isn't that their money? if not, to whom did their money go? Easy, the scheme wasn't based on contribution so poor people paid the sky high pensions of the chosen few and now the chosen few managed to pin it on themselves. OK MILLENNIALS

        --
        Account abandoned.
        • (Score: 2) by Azuma Hazuki on Wednesday March 04 2020, @03:14AM (1 child)

          by Azuma Hazuki (5086) on Wednesday March 04 2020, @03:14AM (#966317) Journal

          Shut up, Opus Dei. If you were truly Christian you'd be working on a way to sort this out.

          --
          I am "that girl" your mother warned you about...
          • (Score: 2) by Bot on Thursday March 05 2020, @11:54PM

            by Bot (3902) on Thursday March 05 2020, @11:54PM (#967160) Journal

            My homebrew covid-19 variant is not deadly enough to be released, have patience.

            --
            Account abandoned.
        • (Score: 1) by khallow on Wednesday March 04 2020, @07:30PM (5 children)

          by khallow (3766) Subscriber Badge on Wednesday March 04 2020, @07:30PM (#966648) Journal

          So whenever somebody complains of boomers sucking pensions from the state I say: isn't that their money? if not, to whom did their money go?

          Depends on the country, but pay as you go is standard fare with boomers and older generations voting for the dude with the sweetest haircut/promises without regard to future ability to pay up. So no, it's not their money. That money got spent decades ago.

          • (Score: 2) by Bot on Wednesday March 04 2020, @08:11PM (4 children)

            by Bot (3902) on Wednesday March 04 2020, @08:11PM (#966669) Journal

            Exactly. So why blame the victims of theft?

            --
            Account abandoned.
            • (Score: 2, Interesting) by khallow on Thursday March 05 2020, @02:39PM (3 children)

              by khallow (3766) Subscriber Badge on Thursday March 05 2020, @02:39PM (#966942) Journal
              Are they the victims or the thieves? It's one thing if the program should have worked except for the failings or avarice of the leadership, and it's another when the present situation has been predicted for at least half a century as in US Social Security. Then it's straight-up theft from subsequent generations by the generations who got theirs. Boomers are actually about half and half, at least in the US. The early half already has decent pay back on those pensions while the latter half is starting to retire now when the program is starting to go into the red.
              • (Score: 2) by Bot on Thursday March 05 2020, @11:52PM (2 children)

                by Bot (3902) on Thursday March 05 2020, @11:52PM (#967157) Journal

                If you reason in terms of generations, race or wealth, you can reconstruct stuff however you like.
                If I am forced to pay taxes to get pensions and my pension is not there, I am the victim. If the government can't do math and goes under, it is not my fault. Collective responsibility is promoted by the thief for the thief.

                --
                Account abandoned.
                • (Score: 1) by khallow on Friday March 06 2020, @02:58AM (1 child)

                  by khallow (3766) Subscriber Badge on Friday March 06 2020, @02:58AM (#967242) Journal

                  If I am forced to pay taxes to get pensions and my pension is not there, I am the victim.

                  If instead you were forcing others to pay taxes to get your pension, then what are you?

                  • (Score: 2) by Bot on Friday March 06 2020, @02:17PM

                    by Bot (3902) on Friday March 06 2020, @02:17PM (#967410) Journal

                    The government.

                    --
                    Account abandoned.
  • (Score: 3, Insightful) by DannyB on Tuesday March 03 2020, @07:35PM (2 children)

    by DannyB (5839) Subscriber Badge on Tuesday March 03 2020, @07:35PM (#966100) Journal

    It will eventually get rid of boomers

    It will. I'll be in that group. Then it will come for the subsequent generations. And much faster than you think.

    Free clue: each year that passes, you will perceive it to go faster and faster. With each decade, you won't believe how fast that went by.

    --
    If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious
    • (Score: 0) by Anonymous Coward on Wednesday March 04 2020, @01:53AM (1 child)

      by Anonymous Coward on Wednesday March 04 2020, @01:53AM (#966294)

      And yet you're still talking and not dead yet.

      • (Score: 1) by khallow on Wednesday March 04 2020, @07:31PM

        by khallow (3766) Subscriber Badge on Wednesday March 04 2020, @07:31PM (#966650) Journal
        Did you get the bit where things appear slow at first?
  • (Score: 2) by DannyB on Tuesday March 03 2020, @08:16PM (2 children)

    by DannyB (5839) Subscriber Badge on Tuesday March 03 2020, @08:16PM (#966128) Journal

    It will eventually get rid of boomers

    Eh, what's that sonny? Without my glasses, it's too easy to read that as "get rid of boners".

    Now get off my lawn!

    --
    If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious
    • (Score: 0) by Anonymous Coward on Tuesday March 03 2020, @08:58PM (1 child)

      by Anonymous Coward on Tuesday March 03 2020, @08:58PM (#966148)

      Boners? They don't happen anymore.

      It doesn't even pee right. Just dribbles.

      That's not the only thing that's wore out.

      It's getting time, the party is getting stale, and everyone is leaving. To be honest, I can't keep up with the pace of everything changing so fast.

      Everyone seems so much in a useless hurry, who cares if the plane flies as long as it's on schedule and budget?

      I question why I keep taking the pills the doctors give me.

      Seems all I do is provide mirth for the executives if I show I give a damn about anything except a paycheck. But then, they like to watch sports and dogfights too. Not make things.

      I guess that's just how it is. People pay top dollar for the skills of having us at each other's throats. An artisan is just a pawn.

      • (Score: 3, Insightful) by DannyB on Tuesday March 03 2020, @09:23PM

        by DannyB (5839) Subscriber Badge on Tuesday March 03 2020, @09:23PM (#966162) Journal

        Boners? They don't happen anymore.
        It doesn't even pee right. Just dribbles.

        Fun little known fact: one of the common prescription drugs that helps the first of those two things also helps with the second of those two things.

        That's not the only thing that's wore out.

        There are probably drugs for that too. Or a cane to walk with.

        I question why I keep taking the pills the doctors give me.

        I reasonably believe that, for the present, they do improve my quality of life.

        Seems all I do is provide mirth for the executives if I show I give a damn about anything except a paycheck. But then, they like to watch sports and dogfights too. Not make things.

        I guess that's just how it is. People pay top dollar for the skills of having us at each other's throats. An artisan is just a pawn.

        Infighting between management and workers represents a major failure of managers at keeping the workers fighting with each other.

        --
        If you think a fertilized egg is a child but an immigrant child is not, please don't pretend your concerns are religious