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The Latest Hydroxychloroquine Data, As of April 11:
We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.
The good news is that the HCQ/sulfasalazine comparison does not show any real differences in adverse events over one-month courses of treatment. I should note that sulfasalazine is not the most side-effect-free medication in the whole pharmacopeia, but it has not been associated with (for example) QT prolongation, which is one of the things you worry about with hydroxychloroquine. The paper concludes that short-term HCQ monotherapy does appear to be safe, but notes that long-term HCQ dosing is indeed tied to increased cardiovascular mortality.
The trouble comes in with the azithromycin combination. Like many antibiotics (although not amoxicillin), AZM is in fact tied to QT prolongation in some patients, so what happens when it's given along with HCQ, which has the same problem?
Worryingly, significant risks are identified for combination users of HCQ+AZM even in the short-term as proposed for COVID19 management, with a 15-20% increased risk of angina/chest pain and heart failure, and a two-fold risk of cardiovascular mortality in the first month of treatment.
That isn't good. I am very glad to hear that the Raoult group has observed no cardiac events in their studies so far, but I wonder how they have managed to be so fortunate, given these numbers.
Update: here is another new preprint from a multinational team lead out of Brazil. It enrolled 81 patients in a trial of high-dose hydroxychloroquine (600 mg b.i.d. over ten days, total dose 12g) or low-dose (450mg b.i.d. on the first day, qd thereafter for the next four, total dose 2.7g). All patients also received azithromycin and ceftriaxone (a cephalosporin antibiotic). The high-dose patients showed more severe QT prolongation and there a trend toward higher lethality compared to the low dose. The overall fatality rate across both arms of the study was 13.5% (so far), which they say overlaps with the historical fatality rate of patients not receiving hydroxychloroquine. The authors actually had to stop recruiting patients for the high-dose arm of the study due to the cardiovascular events, but they're continuing to enroll people in the low-dose group to look at overall mortality. The paper mentions that HCQ has been mandated as the standard therapy in Brazil, so there is no way to run a non-HCQ control group, though.
(Score: 0) by Anonymous Coward on Monday April 13 2020, @02:52AM (8 children)
I find it an interesting coincdience that Boris went from okay to nearly dying in the ICU to looking better than ever in a period of like 3 days. Immediately following his miraculous and ultra-rapid recovery, the NHS has begun more widespread trials of the droxy at St. Bartholomew’s Hospital in London and the Royal Devon and Exeter Hospital.
(Score: 2) by JoeMerchant on Monday April 13 2020, @03:03AM (1 child)
Twice daily monitoring for signs of infection plus unlimited access to Tamiflu and similar well known, but limited supply therapies can indeed do wonders. I suspect Trump underwent a similar therapy early on when he was rumored to have COVID and laid lower than usual out of the spotlight for a few days.
The whole problem with our healthcare systems isn't that we don't know what to do, it's that we lack the capacity to do it for everyone all at the same time.
🌻🌻 [google.com]
(Score: 4, Interesting) by Anonymous Coward on Monday April 13 2020, @04:55AM
John Hopkins maintains a running page of treatments [hopkinsguides.com] tried on COVID here. Tamiflu is useless.
On that note, this [nih.gov] paper is worth giving a read. Tamiflu is likely just another hyper-commercialized non-drug. It performed no better than placebo in independent studies and comes with a mountain of unreported, and often quite extreme, side effects. It made Roche $18 billion though. And I'm sure they made sure to thank their buddies at the FDA.
(Score: 3, Insightful) by barbara hudson on Monday April 13 2020, @03:12AM (2 children)
SoylentNews is social media. Says so right in the slogan. Soylentnews is people, not tech.
(Score: 0) by Anonymous Coward on Monday April 13 2020, @04:00AM
I am referring to his time in hospital and ICU in particular. You don't come out of the ICU looking suddenly like a new man, let alone after such a brief time.
(Score: 0) by Anonymous Coward on Monday April 13 2020, @09:57PM
I "apologized" to you TRANNY twisto https://soylentnews.org/comments.pl?cid=937346&sid=35327 [soylentnews.org] ? FUCK NO, not ever: That's NOT me but I DESTROYED YOU PUBLICLY on every level including proving you barb stalk me on THIS SITE https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] with more proof QUOTED FROM YOU DIRECTLY barbara (tom) hudson proving are a technical incompetent brain-damaged transsexual fool BULLSHIT ARTIST FUCKUP worthless creep that also failed on tech vs. me.
My post LITERALLY also shows links to stopping hundreds of threats of MANY KINDS via hosts (since 99% of malicious threats online use hostnames - block them as I do in hosts (less overhead vs. ANYTHING else by FAR & pure kernelmode TCP/IP stack efficient no less)? Can't TOUCH you nor you it. That's ONLY a 1 year only as a sample and I'd done TONS MORE many hundreds more at slashdot before that and yes 99% use hostnames so hosts work against them harming you).
So much for your usual lies barb and useless online troll chatterbox you has never done better work and I fairly challenged you to show you did. You have not.
NOW: You RESORTING TO IMPERSONATING ME on your end only PROVES I really got to you barb/tom hudson tranny.
So much so you are reduced to showing us your true scum bag self in fact. Thought YOU were going to SUE me? LMAO for what? FACTS ABOUT YOU??? LOL!
* YOU WILL ALWAYS FAIL vs. me just as you FAILED @ being a MAN & since you couldn't GET ANY PUSSY you (lmao) DECIDED in your DRUG ADDLED BRAIN to SLICE OFF YOUR COCK & build your OWN pussy (only way you'd "get some", ever).... OMG!
Only thing that "looks like SHIT" is you you FUCKED UP abomination of desolation freak.
APK
P.S.=> Hey FREAK? I'm going to PUBLICLY EMBARRASS YOUR ASS SO BAD on this site you will have to SLINK AROUND IN SHAME publicly but then, "your kind" (massive MASSIVE total losers in life) are USED to that, aren't you? You don't LIKE IT but I LOVE doing it, exposing you as the TRASH you are fucker... apk
(Score: 2) by Azuma Hazuki on Monday April 13 2020, @02:34PM (1 child)
Fuck. I was wondering what was going to happen to him. It would have been poetically-just in the extreme if his fat NHS-wrecking Tory ass had died of this..
I am "that girl" your mother warned you about...
(Score: -1, Troll) by Anonymous Coward on Monday April 13 2020, @07:35PM
Are you such a loser than you have nothing better to do with your life than wish death on others? Are you that sick of an individual that you wish deadly viruses on people because you disagree with their politics? The answer is yes to both questions. Even if you truly despise someone, you ought to be intelligent enough to not want that person to take up an ICU bed or a ventilator because they contracted the virus. But you really are quite stupid.
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e_\_______|_/_______/__\\\___--___\\_______:____e_ _
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o______\_____\______//_________(_(__>__\___|____o_ _
a_______\___.__C____)_________(_(____>__|__/____a_ _
t_______/\_|___C_____)/Azuma_\_(_____>__|_/_____t_ _
s______/_/\|___C_____)_Hazuki|__(___>___/__\____s_ _
e_____|___(____C_____)\______/__//__/_/_____\___e_ _
x_____|____\__|_____\\_________//_(__/_______|__x_ _
*____|_\____\____)___`----___--'_____________|__*_ _
g____|__\______________\_______/____________/_|_g_ _
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a___|_____________|____/_______\__\___________|_a_ _
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*_g_o_a_t_s_e_x_*_g_o_a_t_s_e_x_*_g_o_a_t_s_e_x_*_
(Score: 0) by Anonymous Coward on Monday April 13 2020, @03:40PM
He didn't go to "nearly dying". He was put into the ICU "in case he needed more services". Ie, your leaders get better access to medical care.