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The Latest Hydroxychloroquine Data, As of April 11:
We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.
The good news is that the HCQ/sulfasalazine comparison does not show any real differences in adverse events over one-month courses of treatment. I should note that sulfasalazine is not the most side-effect-free medication in the whole pharmacopeia, but it has not been associated with (for example) QT prolongation, which is one of the things you worry about with hydroxychloroquine. The paper concludes that short-term HCQ monotherapy does appear to be safe, but notes that long-term HCQ dosing is indeed tied to increased cardiovascular mortality.
The trouble comes in with the azithromycin combination. Like many antibiotics (although not amoxicillin), AZM is in fact tied to QT prolongation in some patients, so what happens when it's given along with HCQ, which has the same problem?
Worryingly, significant risks are identified for combination users of HCQ+AZM even in the short-term as proposed for COVID19 management, with a 15-20% increased risk of angina/chest pain and heart failure, and a two-fold risk of cardiovascular mortality in the first month of treatment.
That isn't good. I am very glad to hear that the Raoult group has observed no cardiac events in their studies so far, but I wonder how they have managed to be so fortunate, given these numbers.
Update: here is another new preprint from a multinational team lead out of Brazil. It enrolled 81 patients in a trial of high-dose hydroxychloroquine (600 mg b.i.d. over ten days, total dose 12g) or low-dose (450mg b.i.d. on the first day, qd thereafter for the next four, total dose 2.7g). All patients also received azithromycin and ceftriaxone (a cephalosporin antibiotic). The high-dose patients showed more severe QT prolongation and there a trend toward higher lethality compared to the low dose. The overall fatality rate across both arms of the study was 13.5% (so far), which they say overlaps with the historical fatality rate of patients not receiving hydroxychloroquine. The authors actually had to stop recruiting patients for the high-dose arm of the study due to the cardiovascular events, but they're continuing to enroll people in the low-dose group to look at overall mortality. The paper mentions that HCQ has been mandated as the standard therapy in Brazil, so there is no way to run a non-HCQ control group, though.
(Score: -1, Troll) by Anonymous Coward on Monday April 13 2020, @10:18PM (2 children)
I "apologized" to you TRANNY twisto https://soylentnews.org/comments.pl?cid=937346&sid=35327 [soylentnews.org] ? FUCK NO, not ever: That's NOT me but I DESTROYED YOU PUBLICLY on every level including proving you barb stalk me on THIS SITE https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] with more proof QUOTED FROM YOU DIRECTLY barbara (tom) hudson proving are a technical incompetent brain-damaged transsexual fool BULLSHIT ARTIST FUCKUP worthless creep that also failed on tech vs. me.
My post LITERALLY also shows links to stopping hundreds of threats of MANY KINDS via hosts (since 99% of malicious threats online use hostnames - block them as I do in hosts (less overhead vs. ANYTHING else by FAR & pure kernelmode TCP/IP stack efficient no less)? Can't TOUCH you nor you it. That's ONLY a 1 year only as a sample and I'd done TONS MORE many hundreds more at slashdot before that and yes 99% use hostnames so hosts work against them harming you).
So much for your usual lies barb and useless online troll chatterbox you has never done better work and I fairly challenged you to show you did. You have not.
NOW: You RESORTING TO IMPERSONATING ME on your end only PROVES I really got to you barb/tom hudson tranny.
So much so you are reduced to showing us your true scum bag self in fact. Thought YOU were going to SUE me? LMAO for what? FACTS ABOUT YOU??? LOL!
* YOU WILL ALWAYS FAIL vs. me just as you FAILED @ being a MAN & since you couldn't GET ANY PUSSY you (lmao) DECIDED in your DRUG ADDLED BRAIN to SLICE OFF YOUR COCK & build your OWN pussy (only way you'd "get some", ever).... OMG!
Only thing that "looks like SHIT" is you you FUCKED UP abomination of desolation freak.
APK
P.S.=> Hey FREAK? I'm going to PUBLICLY EMBARRASS YOUR ASS SO BAD on this site you will have to SLINK AROUND IN SHAME publicly but then, "your kind" (massive MASSIVE total losers in life) are USED to that, aren't you? You don't LIKE IT but I LOVE doing it, exposing you as the TRASH you are fucker... apk
(Score: -1, Offtopic) by Anonymous Coward on Monday April 13 2020, @11:02PM (1 child)
I see you've been quite busy spamming about hosts [soylentnews.org] and posting personal attacks [soylentnews.org]. Clearly you have nothing better to do with your life. Barbara Hudson pretty much owns you because you obsess over her. She can post a couple of comments and you'll spend your whole day spamming replies that continually get modded down. Face it, Barbara Hudson is your god.
And you really should stay away from fake news like Infowars. You also clearly don't know anything about medicine, otherwise you wouldn't post such embarrassing nonsense. Maybe you'll finally learn by getting coronavirus, refusing actual medical treatment in favor of taking zinc supplements, and die because you followed bogus "medical" advice instead of actually being treated.
(Score: -1, Spam) by Anonymous Coward on Thursday April 16 2020, @02:53PM
barbara hudson tranny apk totally owned you here https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] with facts of your multiple failings against him in tech and otherwise. Additionally, it's clear you are caught putting out impersonations of apk too? How embarassing for you tranny weirdo. Just as embarassing as being the parody of a human being you are.