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posted by Fnord666 on Monday April 13 2020, @01:12AM   Printer-friendly

The Latest Hydroxychloroquine Data, As of April 11:

We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.

The good news is that the HCQ/sulfasalazine comparison does not show any real differences in adverse events over one-month courses of treatment. I should note that sulfasalazine is not the most side-effect-free medication in the whole pharmacopeia, but it has not been associated with (for example) QT prolongation, which is one of the things you worry about with hydroxychloroquine. The paper concludes that short-term HCQ monotherapy does appear to be safe, but notes that long-term HCQ dosing is indeed tied to increased cardiovascular mortality.

The trouble comes in with the azithromycin combination. Like many antibiotics (although not amoxicillin), AZM is in fact tied to QT prolongation in some patients, so what happens when it's given along with HCQ, which has the same problem?

Worryingly, significant risks are identified for combination users of HCQ+AZM even in the short-term as proposed for COVID19 management, with a 15-20% increased risk of angina/chest pain and heart failure, and a two-fold risk of cardiovascular mortality in the first month of treatment.

That isn't good. I am very glad to hear that the Raoult group has observed no cardiac events in their studies so far, but I wonder how they have managed to be so fortunate, given these numbers.

Update: here is another new preprint from a multinational team lead out of Brazil. It enrolled 81 patients in a trial of high-dose hydroxychloroquine  (600 mg b.i.d. over ten days, total dose 12g) or low-dose (450mg b.i.d. on the first day, qd thereafter for the next four, total dose 2.7g). All patients also received azithromycin and ceftriaxone (a cephalosporin antibiotic). The high-dose patients showed more severe QT prolongation and there a trend toward higher lethality compared to the low dose. The overall fatality rate across both arms of the study was 13.5% (so far), which they say overlaps with the historical fatality rate of patients not receiving hydroxychloroquine. The authors actually had to stop recruiting patients for the high-dose arm of the study due to the cardiovascular events, but they're continuing to enroll people in the low-dose group to look at overall mortality. The paper mentions that HCQ has been mandated as the standard therapy in Brazil, so there is no way to run a non-HCQ control group, though.

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  • (Score: -1, Troll) by Anonymous Coward on Saturday April 18 2020, @04:40PM (9 children)

    by Anonymous Coward on Saturday April 18 2020, @04:40PM (#984592)

    PROVE you are a MERE 'tech' you FAKENAME fuck online - good luck & does THAT qualify YOU to break the GOLDWATER RULE in accusing (or even insinuating) onto others of being "mental" minus a formal psychiatric exam given in a professional psychiatric environs also STUPID?

    No, it doesn't - FUCKER, you are TOO STUPID to live... you don't HAVE any REAL PROOF of your bullshit. None/Zero/Nada/Zip... but that's all you EVER have in life, isn't it?

    * Even IF you COULD PROVE (which you can't) you ARE a mere pill pushing pimp, that doesn't make you a psychiatric pro stupid... but my calling you STUPID is completely clean on the grounds above & your SELF-PROCLAIMED "SiDeWaLk-ShRiNk of SOYLENTNEWS" 'status' (lol).


    P.S.=> It's been a REAL PLEASURE showing the PLANET how totally FUCKING DUMB you really are - & I thank you for that + the opportunity to BLOW YOU AWAY easily (notice all your downmods of my post went away too, lol - you & all "your kind" (fakename forums fucks) lose vs. me as always).... apk

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  • (Score: 2) by Azuma Hazuki on Sunday April 19 2020, @01:55AM (8 children)

    by Azuma Hazuki (5086) Subscriber Badge on Sunday April 19 2020, @01:55AM (#984746) Journal

    I'm not dumb enough to post my actual PTCB registration number on this forum, Jesus. What kind of proof would you accept?

    As to "fake name," my real one is visible (Marissa van Eck) and if you went through enough trouble you could probably locate me in meatspace since I'm not bouncing my posts through a friend's Linode as of last May. But even if you did, so what? What are you going to do, try and tell the pharmacy I work at that I'm not an actual certified tech, when I have the physical printout of my test scores and certificate of accredition frames and hanging in the office?

    "Azuma Hazuki" is more or less "Jane Doe from Tokyo," with "Azuma" being one reading of the same character that gives the city its "To-" part of its name. "Hazuki" is the archaic name for the old 8th Lunar month, more or less "Augusta" in English the way some girls are called April, May, or June. The name is a callsign for friends from high school and college to recognize me if they ever by chance come here, and has some heavy symbolic meaning to me.

    You're not well, Alex. You somehow manage to type the way I imagine a paranoid schizophrenic talks, which is either sad beyond words or an impressive piece of method acting. Get help. There is treatment available for the psychotic class of disorder and not all of it is those awful -done drugs.

    I am "that girl" your mother warned you about...
    • (Score: -1, Spam) by Anonymous Coward on Tuesday April 21 2020, @02:53AM (4 children)

      by Anonymous Coward on Tuesday April 21 2020, @02:53AM (#985329)

      Marissa Van Eck: Do you WANT to be sued? To wit: You ARE more than merely insinuating I am "mentally ill" etc. - DO YOU HAVE A FORMAL PROFESSIONAL PSYCHIATRIC EXAM given to ME in a professional psychiatric environs saying I am? NO. Are YOU a degreed & licensed practicing psychiatric pro yourself?? NO again.



      P.S.=> See, the wonderful thing here, is this: You claim to be a PILL PUSHING PIMP but don't prove it (figures from "your kind", FAKENAMES online) when you were asked & CHUMP? CLUE: That does NOT give YOU the right to LIBEL me that way (especially since you have NO FACTS TO BACK YOU). Secondly, I put out information in my parent post that a "von braino" (meaning stupid from me to YOU, lol, because you clearly are stupid) wasn't aware of "Dr. WANNABE" (the "SiDeWaLk-ShRiNk of SOYLENTNEWS" = FAKENAME cartoon character PHANTASYLAND dumbo CUNT in you, "Azuka VON DUMBO" = lol)... apk

      • (Score: 2, Interesting) by Anonymous Coward on Tuesday April 21 2020, @06:12AM (3 children)

        by Anonymous Coward on Tuesday April 21 2020, @06:12AM (#985353)

        That would be hilarious if you tried. Absolutely no judge or jury would rule in your favor. Suing for defamation requires that you prove actual damages from the alleged defamatory statements. You've absolutely trashed your reputation across multiple sites to the point that there isn't a whole lot that can damage it further. If you truly cared about your reputation, you would have conducted yourself in a civil and decent manner online. Frankly speaking, Azuma is being quite charitable toward you by attributing your behavior to severe mental illness rather than you being a complete asshole. If you sued Azuma for defamation, you would lose and be responsible for paying her attorney fees.

        Whining about libel is rich coming from you, considering you've harassed and lied about many people. The list includes c6gunner, webmistressrachel, amicusNYCL, Coren22, arth1, barbara hudson, and many others. That doesn't include the vicious personal attacks you continue to lob against people like Thor Schrock. You've made veiled threats to conduct denial of service attacks against both Slashdot and SoylentNews as well as posting vicious personal attacks against Logan Abbott. You continue to spam antisemitic comments [] just like you did on Slashdot. Anonymous posting was disabled on Slashdot in large part due to your antisemitic spam and flagrant harassment of barbara hudson. You've also insinuated that other ArsTechnica admins are involved in pedophilia besides the one individual who actually was convicted. That last bit very well could actually constitute libel.

        And now you want to pretend that you're a victim? Take your crybaby shit and shove it up your ass. If you want sympathy, go look between r and t in the fucking dictionary. You will get absolutely none from me. At least Terry Davis was a competent programmer and TempleOS was a rather intriguing project. You, however, contribute very little and your destructive behavior far outweighs any productive contributions you may have made. Fuck right off.

        • (Score: 1, Insightful) by Anonymous Coward on Tuesday April 21 2020, @07:22AM

          by Anonymous Coward on Tuesday April 21 2020, @07:22AM (#985366)

          FWIW, that is actually an common misconception. While not taking a position either way as to whether these are or not, it is important to point out that there are statements that don't require damages to be proved because they are inherently damaging [].

        • (Score: -1, Spam) by Anonymous Coward on Tuesday April 21 2020, @04:00PM (1 child)

          by Anonymous Coward on Tuesday April 21 2020, @04:00PM (#985463)

          See my subject (hilarious) since all I asked was a question & you "PaNiCkEd" out of SHEER SELF-PROFESSED GUILT & you ought to read about INHERENTLY DAMAGING STATEMENTS per wikipedia that YOU MADE MY WAY others noted to you here [] , STUPID (because you ARE breaking laws such as the ,b>GOLDWATER RULE when you libeled me publicly MINUS psychiatric evidence thru this exchange).

          Also, in addition to that, I KNOW YOU ARE BROKE AS A JOKE & BARELY ABLE TO MAKE RENT IN NYC (yes, I've seen you "crying" about the NYC economic shutdown on forums online) with YOU as a MERE PILL PUSHING PIMP (pharmakeia, which figures from "your kind").

          And YES, I know YOUR KIND since I KNOW you HATE GOD per your reply to others here [] Marissa Van Eck - you sound like some DEVIL WORSHIPPING freak when you said "You are a whore, OP. And you are going to get thrown away by your pimp Yahweh." it's that OR that you are an ex-prostitute!)

          * So Marissa Van Eck/alias cartoon character phantasyland FAKENAME freak 'Azuki von DUMBO - get a life, loser... you're too STUPID (& broke/worthless) to live, let alone even WORTH bringing a libel/defamation of character suit against.

          (As to your LIST OF SLASHDOT do-nothing ALL TALK waste of life MORONS? I've CRUSHED EVERY SINGLE ONE OF THEM with FACTS they started it, I finished EVERY SINGLE ONE OFF with their OWN STUPID ERRORS & MISTAKES, easily - undeniable, concrete & verifiable in every case, but that's what happens to MORONS & LOSER that "try me" - their OWN stupidity in trying to "take me on" caused them PUBLIC HUMILIATION which obviously, is NOTHING NEW to "their/your kind" that HIDE BEHIND FAKENAMES ONLINE since their REAL LIVES are like yours - that of a freak loser, no questions asked)

          WoW - talk hypocrisy - Me, playing "Victim"? That's a laugh: You DUMB bitch - all you DID was provide a LIST OF MY VICTIMS I annihilated, rightfully so for attacking me & lying about me, with ease & like you?

          The STUPID cocksuckers started up trouble w/ ME 1st & I publicly DESTROYED each of them using FACTS, not LIES like you have on me in your LIBEL of myself here in this exchange (as they "hide" behind FAKENAMES online, lol - many of which I got out of them OR found their REAL NAMES & where they live, easily).

          Contributions? At least I MAKE GOOD ONES (& have been shown in publication in the field of computing MANY TIMES with even COMMERCIALLY SOLD CODE to MY NAME for DECADES now that WON a FINALIST POSITION @ Microsoft Tech-Ed 2000-2002 2 times in a ROW in its HARDEST CATEGORY of SQLServer Performance Enhancement - have you? No, of COURSE not - you're a FAKENAME since you are a FAKE wasted LIFE).

          LASTLY As far as JEWS? The SYNAGOGUE OF SATAN per REVELATION by John (those who SAY they are JEWS but are not but instead HIDE BEHIND decent jews (very few imo))??


          Hmmm? I don't see any other race/creed/people going thru THAT - but then, EVERYONE KNOWS THEY CAUSE IT FOR THEMSELVES (or were nations that existed LONG BEFORE WWII all "nazis"? LOL...)


          P.S.=> You can't say you "obeyed the law" when you CLEARLY STATED that I, APK, am "mental" etc. above(MINUS actual evidence from YOU by REAL psychiatric pros against me) & yes, that YOU CLEARLY STARTED UP TROUBLE w/ ME on those grounds, STUPID - & your "ReAcTioN"? Priceless, lol... apk

          • (Score: 2) by Azuma Hazuki on Wednesday April 22 2020, @01:44AM

            by Azuma Hazuki (5086) Subscriber Badge on Wednesday April 22 2020, @01:44AM (#985641) Journal

            That wasn't me, dipfuck. I don't post AC (unlike you, you gormless coward) unless by accident, and then always reply to it with a logged in "hurr derp that was me."

            I can't even bring myself to pity you, Mr. Kowalski. What kind of broken wreck of a human being acts like this? What happened to you to make you turn out this way? Some part of me doesn't want to know, but I've always had a problem with morbid curiosity...

            I am "that girl" your mother warned you about...
    • (Score: -1, Spam) by Anonymous Coward on Tuesday April 21 2020, @11:22PM (2 children)

      by Anonymous Coward on Tuesday April 21 2020, @11:22PM (#985585)

      See subject: I'm so sick & tired of SoylentNews BULLIES just like the /. & ArSeHoleTechnica bullies. You SHITWEASELS have nothing better to do than HARASS, STALK & IMPERSONATE little ol' me. I've done absolutely NOTHING wrong & just try to make everyone's lives better w/ my work that stops ads & malware.

      * As soon as I post, I'm CENSORED to -1 w/ ABUSED spamdownmodpoints by FAKENAME bullies like The Mighty Buzzard, Runaway1956, Azuma Hazuki & Tom "Barbara" Hudson. I caught c6gunner mocking then IMPERSONATING me on /. when he forgot to log out. Zontar The Mindless mailed me a postcard w/ THREATS on it, then LIES & STALKS me. All because you JEALOUS JOWIE "ne'er-do-wells" KNOW I'm World-Class & you're shit. It's why you hide behind FAKE names & UNIDENTIFIABLE ANONYMOUS.

      I caught Tom "Barbara" Hudson IMPERSONATING me too. The OLD NOT-MAN soyboy weezil is JUDEN TRASH and knows nothing about computers so IT LIES about me instead. This is one sick in the head IDLE HANDS ARE THE DEVIL'S WORKSHOP abomination, no questions asked. You wish you were me & that's why you IMPERSONATE & ATTACK me.

      I'm even improving my already GREAT PHYSIQUE & SUPERIOR INTELLECT while you weezils & soyboys sit around all day on SoylentNews STALKING & HARASSING your BETTERS. I repeatedly dust the no-mind bullshit blatherings you BULLIES post to attack me. Like always I WIN & YOU LOSE. That's why you keep spamdownmod HIDING my posts & STALKING me w/ FAKENAME accounts. You CAN'T stop me any better than whipslash @ /. & he knows I could STOP HIS SERVER whenever I want. Martyb KNOWS he CAN'T DO BETTER than I w/ APK Hosts File Engine instead of some TOY website based on someone else's ABANDONED & BROKEN code from another site FULL of "ne'er-do-well" fakename forum focks.

      Now I have the PILL-PUSHING SELF-PROCLAIMED "SiDeWaLk-ShRiNk of SOYLENTNEWS" LIBELING me & saying I'm MENTALLY ILL. ALL of you SHITWEASELS are mentally ill & can't stop BULLYING me because you WISH YOU WERE ME. PROVE you've done better than I. You can't & you know it so BULLYING & LIBELING is all YOUR KIND has left.


      P.S.=> This BULLYING of me is SO UNFAIR & I've done nothing to deserve it from you people. I'm tired of CASTING PEARLS before SWINE with my work that you CAN'T do better than. GROW UP... apk

      • (Score: -1, Spam) by Anonymous Coward on Wednesday April 22 2020, @12:06AM (1 child)

        by Anonymous Coward on Wednesday April 22 2020, @12:06AM (#985602)

        LmAo: Impersonating me doing what I'd never do (which is "play victim" when the truth is you made YOURSELVES my victims being STUPID ENOUGH to try "take me on" only to go "SPLAT" after I knocked you all flat via facts vs. your errors - classic case? Barbara Hudson [] as just 1 single example thereof as proof, no questions asked & undeniable, concrete, & factually verifiable on all grounds of how I TOTALLY SPLATTERED that fucking tranny weirdo).

        * I do like what you PROJECTED though about my type of person vs. "your kind" (SLIMY little SLINKING worms that play BITCH games like IMPERSONATING me).


        P.S.=> What a pack of SERIOUS BOZOS lurk around this shithole - glad I'm NOT one of you, that's certain... apk

        • (Score: 0) by Anonymous Coward on Wednesday April 22 2020, @12:40AM

          by Anonymous Coward on Wednesday April 22 2020, @12:40AM (#985616)

          Except that you are playing victim. You claim that Azuma libeled you, loudly whining about it. Then you claim that you're being "impersonated" when you can immediately stop it by logging into your account [], which you already have.

          I have a theory. I think you're shitposting, then saying that someone impersonated you. That way, you can lie and pretend that everyone is out to get you.