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The Latest Hydroxychloroquine Data, As of April 11:
We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.
The good news is that the HCQ/sulfasalazine comparison does not show any real differences in adverse events over one-month courses of treatment. I should note that sulfasalazine is not the most side-effect-free medication in the whole pharmacopeia, but it has not been associated with (for example) QT prolongation, which is one of the things you worry about with hydroxychloroquine. The paper concludes that short-term HCQ monotherapy does appear to be safe, but notes that long-term HCQ dosing is indeed tied to increased cardiovascular mortality.
The trouble comes in with the azithromycin combination. Like many antibiotics (although not amoxicillin), AZM is in fact tied to QT prolongation in some patients, so what happens when it's given along with HCQ, which has the same problem?
Worryingly, significant risks are identified for combination users of HCQ+AZM even in the short-term as proposed for COVID19 management, with a 15-20% increased risk of angina/chest pain and heart failure, and a two-fold risk of cardiovascular mortality in the first month of treatment.
That isn't good. I am very glad to hear that the Raoult group has observed no cardiac events in their studies so far, but I wonder how they have managed to be so fortunate, given these numbers.
Update: here is another new preprint from a multinational team lead out of Brazil. It enrolled 81 patients in a trial of high-dose hydroxychloroquine (600 mg b.i.d. over ten days, total dose 12g) or low-dose (450mg b.i.d. on the first day, qd thereafter for the next four, total dose 2.7g). All patients also received azithromycin and ceftriaxone (a cephalosporin antibiotic). The high-dose patients showed more severe QT prolongation and there a trend toward higher lethality compared to the low dose. The overall fatality rate across both arms of the study was 13.5% (so far), which they say overlaps with the historical fatality rate of patients not receiving hydroxychloroquine. The authors actually had to stop recruiting patients for the high-dose arm of the study due to the cardiovascular events, but they're continuing to enroll people in the low-dose group to look at overall mortality. The paper mentions that HCQ has been mandated as the standard therapy in Brazil, so there is no way to run a non-HCQ control group, though.
(Score: -1, Spam) by Anonymous Coward on Tuesday April 21 2020, @04:00PM (1 child)
See my subject (hilarious) since all I asked was a question & you "PaNiCkEd" out of SHEER SELF-PROFESSED GUILT & you ought to read about INHERENTLY DAMAGING STATEMENTS per wikipedia that YOU MADE MY WAY others noted to you here https://soylentnews.org/comments.pl?noupdate=1&sid=37033&page=1&cid=985366#commentwrap [soylentnews.org] , STUPID (because you ARE breaking laws such as the ,b>GOLDWATER RULE when you libeled me publicly MINUS psychiatric evidence thru this exchange).
Also, in addition to that, I KNOW YOU ARE BROKE AS A JOKE & BARELY ABLE TO MAKE RENT IN NYC (yes, I've seen you "crying" about the NYC economic shutdown on forums online) with YOU as a MERE PILL PUSHING PIMP (pharmakeia, which figures from "your kind").
And YES, I know YOUR KIND since I KNOW you HATE GOD per your reply to others here https://redeeminggod.com/sermons/luke/luke_7_36-50/ [redeeminggod.com] Marissa Van Eck - you sound like some DEVIL WORSHIPPING freak when you said "You are a whore, OP. And you are going to get thrown away by your pimp Yahweh." it's that OR that you are an ex-prostitute!)
* So Marissa Van Eck/alias cartoon character phantasyland FAKENAME freak 'Azuki von DUMBO - get a life, loser... you're too STUPID (& broke/worthless) to live, let alone even WORTH bringing a libel/defamation of character suit against.
(As to your LIST OF SLASHDOT do-nothing ALL TALK waste of life MORONS? I've CRUSHED EVERY SINGLE ONE OF THEM with FACTS they started it, I finished EVERY SINGLE ONE OFF with their OWN STUPID ERRORS & MISTAKES, easily - undeniable, concrete & verifiable in every case, but that's what happens to MORONS & LOSER that "try me" - their OWN stupidity in trying to "take me on" caused them PUBLIC HUMILIATION which obviously, is NOTHING NEW to "their/your kind" that HIDE BEHIND FAKENAMES ONLINE since their REAL LIVES are like yours - that of a freak loser, no questions asked)
WoW - talk hypocrisy - Me, playing "Victim"? That's a laugh: You DUMB bitch - all you DID was provide a LIST OF MY VICTIMS I annihilated, rightfully so for attacking me & lying about me, with ease & like you?
The STUPID cocksuckers started up trouble w/ ME 1st & I publicly DESTROYED each of them using FACTS, not LIES like you have on me in your LIBEL of myself here in this exchange (as they "hide" behind FAKENAMES online, lol - many of which I got out of them OR found their REAL NAMES & where they live, easily).
Contributions? At least I MAKE GOOD ONES (& have been shown in publication in the field of computing MANY TIMES with even COMMERCIALLY SOLD CODE to MY NAME for DECADES now that WON a FINALIST POSITION @ Microsoft Tech-Ed 2000-2002 2 times in a ROW in its HARDEST CATEGORY of SQLServer Performance Enhancement - have you? No, of COURSE not - you're a FAKENAME since you are a FAKE wasted LIFE).
LASTLY As far as JEWS? The SYNAGOGUE OF SATAN per REVELATION by John (those who SAY they are JEWS but are not but instead HIDE BEHIND decent jews (very few imo))??
TELL US THEN WHY HAVE JEWS BEEN KICKED OUT OF 109 NATIONS THE LAST 2,000++ or so YEARS?
Hmmm? I don't see any other race/creed/people going thru THAT - but then, EVERYONE KNOWS THEY CAUSE IT FOR THEMSELVES (or were nations that existed LONG BEFORE WWII all "nazis"? LOL...)
APK
P.S.=> You can't say you "obeyed the law" when you CLEARLY STATED that I, APK, am "mental" etc. above(MINUS actual evidence from YOU by REAL psychiatric pros against me) & yes, that YOU CLEARLY STARTED UP TROUBLE w/ ME on those grounds, STUPID - & your "ReAcTioN"? Priceless, lol... apk
(Score: 2) by Azuma Hazuki on Wednesday April 22 2020, @01:44AM
That wasn't me, dipfuck. I don't post AC (unlike you, you gormless coward) unless by accident, and then always reply to it with a logged in "hurr derp that was me."
I can't even bring myself to pity you, Mr. Kowalski. What kind of broken wreck of a human being acts like this? What happened to you to make you turn out this way? Some part of me doesn't want to know, but I've always had a problem with morbid curiosity...
I am "that girl" your mother warned you about...