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The Latest Hydroxychloroquine Data, As of April 11:
We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.
The good news is that the HCQ/sulfasalazine comparison does not show any real differences in adverse events over one-month courses of treatment. I should note that sulfasalazine is not the most side-effect-free medication in the whole pharmacopeia, but it has not been associated with (for example) QT prolongation, which is one of the things you worry about with hydroxychloroquine. The paper concludes that short-term HCQ monotherapy does appear to be safe, but notes that long-term HCQ dosing is indeed tied to increased cardiovascular mortality.
The trouble comes in with the azithromycin combination. Like many antibiotics (although not amoxicillin), AZM is in fact tied to QT prolongation in some patients, so what happens when it's given along with HCQ, which has the same problem?
Worryingly, significant risks are identified for combination users of HCQ+AZM even in the short-term as proposed for COVID19 management, with a 15-20% increased risk of angina/chest pain and heart failure, and a two-fold risk of cardiovascular mortality in the first month of treatment.
That isn't good. I am very glad to hear that the Raoult group has observed no cardiac events in their studies so far, but I wonder how they have managed to be so fortunate, given these numbers.
Update: here is another new preprint from a multinational team lead out of Brazil. It enrolled 81 patients in a trial of high-dose hydroxychloroquine (600 mg b.i.d. over ten days, total dose 12g) or low-dose (450mg b.i.d. on the first day, qd thereafter for the next four, total dose 2.7g). All patients also received azithromycin and ceftriaxone (a cephalosporin antibiotic). The high-dose patients showed more severe QT prolongation and there a trend toward higher lethality compared to the low dose. The overall fatality rate across both arms of the study was 13.5% (so far), which they say overlaps with the historical fatality rate of patients not receiving hydroxychloroquine. The authors actually had to stop recruiting patients for the high-dose arm of the study due to the cardiovascular events, but they're continuing to enroll people in the low-dose group to look at overall mortality. The paper mentions that HCQ has been mandated as the standard therapy in Brazil, so there is no way to run a non-HCQ control group, though.
(Score: -1, Spam) by Anonymous Coward on Tuesday April 21 2020, @11:22PM (2 children)
See subject: I'm so sick & tired of SoylentNews BULLIES just like the /. & ArSeHoleTechnica bullies. You SHITWEASELS have nothing better to do than HARASS, STALK & IMPERSONATE little ol' me. I've done absolutely NOTHING wrong & just try to make everyone's lives better w/ my work that stops ads & malware.
* As soon as I post, I'm CENSORED to -1 w/ ABUSED spamdownmodpoints by FAKENAME bullies like The Mighty Buzzard, Runaway1956, Azuma Hazuki & Tom "Barbara" Hudson. I caught c6gunner mocking then IMPERSONATING me on /. when he forgot to log out. Zontar The Mindless mailed me a postcard w/ THREATS on it, then LIES & STALKS me. All because you JEALOUS JOWIE "ne'er-do-wells" KNOW I'm World-Class & you're shit. It's why you hide behind FAKE names & UNIDENTIFIABLE ANONYMOUS.
I caught Tom "Barbara" Hudson IMPERSONATING me too. The OLD NOT-MAN soyboy weezil is JUDEN TRASH and knows nothing about computers so IT LIES about me instead. This is one sick in the head IDLE HANDS ARE THE DEVIL'S WORKSHOP abomination, no questions asked. You wish you were me & that's why you IMPERSONATE & ATTACK me.
I'm even improving my already GREAT PHYSIQUE & SUPERIOR INTELLECT while you weezils & soyboys sit around all day on SoylentNews STALKING & HARASSING your BETTERS. I repeatedly dust the no-mind bullshit blatherings you BULLIES post to attack me. Like always I WIN & YOU LOSE. That's why you keep spamdownmod HIDING my posts & STALKING me w/ FAKENAME accounts. You CAN'T stop me any better than whipslash @ /. & he knows I could STOP HIS SERVER whenever I want. Martyb KNOWS he CAN'T DO BETTER than I w/ APK Hosts File Engine instead of some TOY website based on someone else's ABANDONED & BROKEN code from another site FULL of "ne'er-do-well" fakename forum focks.
Now I have the PILL-PUSHING SELF-PROCLAIMED "SiDeWaLk-ShRiNk of SOYLENTNEWS" LIBELING me & saying I'm MENTALLY ILL. ALL of you SHITWEASELS are mentally ill & can't stop BULLYING me because you WISH YOU WERE ME. PROVE you've done better than I. You can't & you know it so BULLYING & LIBELING is all YOUR KIND has left.
APK
P.S.=> This BULLYING of me is SO UNFAIR & I've done nothing to deserve it from you people. I'm tired of CASTING PEARLS before SWINE with my work that you CAN'T do better than. GROW UP... apk
(Score: -1, Spam) by Anonymous Coward on Wednesday April 22 2020, @12:06AM (1 child)
LmAo: Impersonating me doing what I'd never do (which is "play victim" when the truth is you made YOURSELVES my victims being STUPID ENOUGH to try "take me on" only to go "SPLAT" after I knocked you all flat via facts vs. your errors - classic case? Barbara Hudson https://soylentnews.org/comments.pl?noupdate=1&sid=33430&page=1&cid=889582#commentwrap [soylentnews.org] as just 1 single example thereof as proof, no questions asked & undeniable, concrete, & factually verifiable on all grounds of how I TOTALLY SPLATTERED that fucking tranny weirdo).
* I do like what you PROJECTED though about my type of person vs. "your kind" (SLIMY little SLINKING worms that play BITCH games like IMPERSONATING me).
APK
P.S.=> What a pack of SERIOUS BOZOS lurk around this shithole - glad I'm NOT one of you, that's certain... apk
(Score: 0) by Anonymous Coward on Wednesday April 22 2020, @12:40AM
Except that you are playing victim. You claim that Azuma libeled you, loudly whining about it. Then you claim that you're being "impersonated" when you can immediately stop it by logging into your account [soylentnews.org], which you already have.
I have a theory. I think you're shitposting, then saying that someone impersonated you. That way, you can lie and pretend that everyone is out to get you.