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From the latest blog post of Derek Lowe :
One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new paper is a good example. A team from the La Jolla Institute for Immunology, UNC, UCSD, and Mt. Sinai (NY) reports details about the T cells of people who have recovered from the virus.
[...] So overall, this paper makes the prospects for a vaccine look good: there is indeed a robust response by the adaptive immune system, to several coronavirus proteins. And vaccine developers will want to think about adding in some of the other antigens mentioned in this paper, in addition to the Spike antigens that have been the focus thus far. It seems fair to say, though, that the first wave of vaccines will likely be Spike-o-centric, and later vaccines might have these other antigens included in the mix. But it also seems that Spike-protein-targeted vaccines should be pretty effective, so that’s good. The other good news is that this team looked for the signs of an antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring). And it also looks like the prospects for (reasonably) lasting immunity after infection (or after vaccination) are good. This, from what I can see, is just the sort of response that you’d want to see for that to be the case. Clinical data will be the real decider on that, but there’s no reason so far to think that a person won’t have such immunity if they fit this profile.
Onward from here, then – there will be more studies like this coming, but this is a good, solid look into the human immunology of this outbreak. And so far, so good.
Be sure to read the article if you’ve been wondering what your thymus has done for you lately.
Journal Reference
Alba Grifoni, Daniela Weiskopf. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals, Cell (DOI: 10.1016/j.cell.2020.05.015)
(Score: 4, Insightful) by Azuma Hazuki on Sunday May 17 2020, @05:11PM (19 children)
What do you suggest then? My main motivation for mixing the two is the flu shots are well-covered by Medicare (so the elderly and very sick get them free). If the government thinks flu is important enough to vaccinate against like that, then nCov-2019 sure as hell ought to be. More so, if anything.
I am "that girl" your mother warned you about...
(Score: 4, Interesting) by PocketSizeSUn on Sunday May 17 2020, @05:38PM
You will need to get the a SARS *series* of vaccines as profitable as the flu vaccine.
https://www.npr.org/sections/health-shots/2019/12/20/784608400/do-you-really-need-a-flu-shot-heres-how-to-decide [npr.org]
https://www.wired.com/story/flu-vaccine-big-pharma/ [wired.com]
https://www.drugwatch.com/news/2018/02/19/us-flu-season-reaches-peak-vaccine-profits-climb/ [drugwatch.com]
Since China is doing the vaccine and GoF research ... we could just wait for a Made-in-China solution to a Made-in-China problem?
Or maybe a little oversight on China's rapid increase in GoF and vaccine research? China is now building out BSL4 labs as fast as they built a containment hospital in Wuhan.
It is also worth noting that China has been doing GoF + SARS development in lower classifcation labs as well as in WIV BSL4 lab. They plan to build 5 to 7 labs
https://www.scientificamerican.com/article/china-to-permit-lab-poised-to-study-worlds-most-dangerous-pathogens/ [scientificamerican.com]
So ask yourself this. Did China react the way they did in Wuhan because they thought the had a SARS outbreak ... or because they thought they had a containment problem of something much worse leak out of WIV?
(Score: 2) by JoeMerchant on Sunday May 17 2020, @07:11PM
Ever the optimist, assuming that the government's primary motivation is protecting the well being of their most costly citizens.
🌻🌻 [google.com]
(Score: 2) by Bot on Monday May 18 2020, @01:17AM (1 child)
Are you aware plasma from survivors does cure the covid? even the evil gates is eyeing that therapy. Using plasma is a delicate matter, sure, but given the way vaccines are manufactured and prescribed, getting plasma should not scare you much.
Account abandoned.
(Score: 2) by Azuma Hazuki on Monday May 18 2020, @01:34PM
Yes, I am. At some point, I plan to get tested, and if it's positive (I've had no symptoms at all, so am either uninfected or asymptomatic and recovered) I plan to donate plasma when possible.
I am "that girl" your mother warned you about...
(Score: 2) by Reziac on Monday May 18 2020, @04:48AM (14 children)
I agree, and take it a step further -- do like was common in the 1980s, and in some places even today -- vaccine is cheap or even free to everyone. Tho it might not be a good idea to combine CV and influenza vaccines; a few weeks apart would be better for maximum immunity and fewest fails/bad reactions. At least until we determine if there's any interaction. (Sometimes one vaccine can interfere with another.)
Up here in Redneck Land, some counties have an RV that tours every wide spot in the road giving out vaccine for every disease known to man... having found that free vaccine is a lot cheaper than treating the illness. Last time I encountered the vaccine tourbus, I went home immune to everything but death and looking like a pincushion. :D
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Monday May 18 2020, @01:35PM (13 children)
Sounds like *socialism* ta me, boy..whah duh yew hayt uh-merrika?
I am "that girl" your mother warned you about...
(Score: 2, Disagree) by Reziac on Monday May 18 2020, @02:03PM (12 children)
Socialism is when you don't have a choice, you participate or else. Socialism only 'works' when there's a man with a gun to enforce participation.
No one forced us to line up for flu vaccine; we merely observed that flu was worse than an hour in line on a subzero night. No one forced county health to juggle numbers and decide vaccine was cheaper than disease. In both cases it was purely enlightened self-interest, for which we were willing to spend a tiny bit of those tax dollars we'd already paid.
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2, Disagree) by Azuma Hazuki on Tuesday May 19 2020, @12:49AM (11 children)
"Or else" what, pray tell? Because in a crony-capitalist milieu like the modern US, the "or else" is equally dire.
I am "that girl" your mother warned you about...
(Score: 2) by Reziac on Tuesday May 19 2020, @01:05AM (10 children)
Or else what? The best answer came from Lenin or Stalin or Mao, tho there have been plenty of also-rans (eg. Castro and Chavez).
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:14AM (9 children)
Same shit happens here in the US, just slower: you die. I think I'd rather be shot than starve. You're dishonest as Hell, you know that?
I am "that girl" your mother warned you about...
(Score: 2) by Reziac on Tuesday May 19 2020, @02:49AM (8 children)
And you're pleasant company, as always.
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Tuesday May 19 2020, @01:26PM (7 children)
Cry harder. I may be unpleasant to the deserving, but I'm also correct. If you don't like getting snarked at, don't say stupid shit.
I am "that girl" your mother warned you about...
(Score: 2, Insightful) by Reziac on Tuesday May 19 2020, @02:50PM (6 children)
No, you're unpleasant because you're wrong and you don't have a good argument, but you do have a fine stable of insults. We all use the skills we're able...
;)
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @12:24AM (5 children)
So this is what you descend to? No, I'm correct, and if I weren't you wouldn't be getting so upset about it. The nastiness is just the well-deserved icing on the cake. Fuck off, keep fucking off until you've circumnavigated the globe and fucked off right back to where you started, then fuck off one more time.
I am "that girl" your mother warned you about...
(Score: 2, Funny) by Reziac on Wednesday May 20 2020, @12:39AM (4 children)
I'm not upset. I love you too. :D
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @05:20AM (3 children)
Denial. Ain't just a big wet in Egypt.
I am "that girl" your mother warned you about...
(Score: 2) by Reziac on Wednesday May 20 2020, @06:38AM (2 children)
You can get Depends for that...
And there is no Alkibiades to come back and save us from ourselves.
(Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @01:10PM (1 child)
If it weren't bothering you, *you wouldn't keep replying.* You fat middle-aged manchildren are all so goddamn *predictable.*
I am "that girl" your mother warned you about...
(Score: 2) by Reziac on Wednesday May 20 2020, @02:45PM
No, I do it to keep YOU replying. Because you're so predictable. :D
And there is no Alkibiades to come back and save us from ourselves.