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posted by martyb on Sunday May 17 2020, @04:17PM   Printer-friendly
from the getting-closer dept.

From the latest blog post of Derek Lowe :

One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new paper is a good example. A team from the La Jolla Institute for Immunology, UNC, UCSD, and Mt. Sinai (NY) reports details about the T cells of people who have recovered from the virus.

[...] So overall, this paper makes the prospects for a vaccine look good: there is indeed a robust response by the adaptive immune system, to several coronavirus proteins. And vaccine developers will want to think about adding in some of the other antigens mentioned in this paper, in addition to the Spike antigens that have been the focus thus far. It seems fair to say, though, that the first wave of vaccines will likely be Spike-o-centric, and later vaccines might have these other antigens included in the mix. But it also seems that Spike-protein-targeted vaccines should be pretty effective, so that’s good. The other good news is that this team looked for the signs of an antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring). And it also looks like the prospects for (reasonably) lasting immunity after infection (or after vaccination) are good. This, from what I can see, is just the sort of response that you’d want to see for that to be the case. Clinical data will be the real decider on that, but there’s no reason so far to think that a person won’t have such immunity if they fit this profile.

Onward from here, then – there will be more studies like this coming, but this is a good, solid look into the human immunology of this outbreak. And so far, so good.

Be sure to read the article if you’ve been wondering what your thymus has done for you lately.

Journal Reference
Alba Grifoni, Daniela Weiskopf. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals, Cell (DOI: 10.1016/j.cell.2020.05.015)


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  • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @12:24AM (5 children)

    by Azuma Hazuki (5086) on Wednesday May 20 2020, @12:24AM (#996631) Journal

    So this is what you descend to? No, I'm correct, and if I weren't you wouldn't be getting so upset about it. The nastiness is just the well-deserved icing on the cake. Fuck off, keep fucking off until you've circumnavigated the globe and fucked off right back to where you started, then fuck off one more time.

    --
    I am "that girl" your mother warned you about...
    Starting Score:    1  point
    Karma-Bonus Modifier   +1  

    Total Score:   2  
  • (Score: 2, Funny) by Reziac on Wednesday May 20 2020, @12:39AM (4 children)

    by Reziac (2489) on Wednesday May 20 2020, @12:39AM (#996636) Homepage

    I'm not upset. I love you too. :D

    • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @05:20AM (3 children)

      by Azuma Hazuki (5086) on Wednesday May 20 2020, @05:20AM (#996757) Journal

      Denial. Ain't just a big wet in Egypt.

      --
      I am "that girl" your mother warned you about...
      • (Score: 2) by Reziac on Wednesday May 20 2020, @06:38AM (2 children)

        by Reziac (2489) on Wednesday May 20 2020, @06:38AM (#996772) Homepage

        You can get Depends for that...

        • (Score: 2) by Azuma Hazuki on Wednesday May 20 2020, @01:10PM (1 child)

          by Azuma Hazuki (5086) on Wednesday May 20 2020, @01:10PM (#996861) Journal

          If it weren't bothering you, *you wouldn't keep replying.* You fat middle-aged manchildren are all so goddamn *predictable.*

          --
          I am "that girl" your mother warned you about...
          • (Score: 2) by Reziac on Wednesday May 20 2020, @02:45PM

            by Reziac (2489) on Wednesday May 20 2020, @02:45PM (#996905) Homepage

            No, I do it to keep YOU replying. Because you're so predictable. :D