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Virginia Tech drug researcher develops 'fat burning' molecule that has implications for treatment of obesity (Science Daily)
"Obesity is the biggest health problem in the United States. But, it is hard for people to lose weight and keep it off; being on a diet can be so difficult. So, a pharmacological approach, or a drug, could help out and would be beneficial for all of society," said Webster Santos, professor of chemistry and the Cliff and Agnes Lilly Faculty Fellow of Drug Discovery in the College of Science at Virginia Tech.
Santos and his colleagues have recently identified a small mitochondrial uncoupler, named BAM15, that decreases the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature. Additionally, the molecule decreases insulin resistance and has beneficial effects on oxidative stress and inflammation.
The findings, published in Nature Communications on May 14, 2020, hold promise for future treatment and prevention of obesity, diabetes, and especially nonalcoholic steatohepatitis (NASH), a type of fatty liver disease that is characterized by inflammation and fat accumulation in the liver. In the next few years, the condition is expected to become the leading cause of liver transplants in the United States.
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice (open, DOI: 10.1038/s41467-020-16298-2) (DX)
Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells (open, DOI: 10.1016/j.apsb.2018.07.010) (DX)
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control (open, DOI: 10.15252/emmm.202012088) (DX)
(Score: 0) by Anonymous Coward on Monday June 15 2020, @01:38AM
Get more fats in your diet. Cut carbs and sugars to keep the calories down. The hunger you feel when you are not getting enough fat is akin to the thirst a vampire feels. It will just keep building until you eat enough fat. Doctors' recommendations to "cut fat" and "lo-fat" foods are responsible for a large part of the obesity epidemic.
Similarly with the bullshit about salt. 10% of people need to watch their salt intake. Everybody else just pisses out the excess. Trouble is that 10% have such a bad reaction that statistically salt looks really bad.
"Too much salt and 10% of people get really high blood pressure! Strokes!! Heart attacks!! Everybody should cut their salt intake"
In reality, 100% of 10% will get really high blood pressure. 90% are fine.