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Life-saving coronavirus drug 'major breakthrough':
A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus.
The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say.
The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus.
[...] The drug is already used to reduce inflammation in a range of other conditions, and it appears that it helps stop some of the damage that can happen when the body's immune system goes into overdrive as it tries to fight off coronavirus.
[...] In the trial, led by a team from Oxford University, around 2,000 hospital patients were given dexamethasone and were compared with more than 4,000 who did not receive the drug.
For patients on ventilators, it cut the risk of death from 40% to 28%. For patients needing oxygen, it cut the risk of death from 25% to 20%.
Chief investigator Prof Peter Horby said: "This is the only drug so far that has been shown to reduce mortality - and it reduces it significantly. It's a major breakthrough."
[...] Dexamethasone has been used since the early 1960s to treat a wide range of conditions, such as rheumatoid arthritis and asthma.
[...] The drug is given intravenously in intensive care, and in tablet form for less seriously ill patients. So far, the only other drug proven to benefit Covid patients is remdesivir, an antiviral treatment which has been used for Ebola.
(Score: 5, Interesting) by RS3 on Wednesday June 17 2020, @02:04AM
It's important to remember that many infectious diseases don't kill you directly by themselves, rather you die from the effects, such as severe lung dysfunction in COVID-19, pneumonia, etc., which (sadly) is caused by inflammation, which is caused by immune response.
My take on it: if you're on ventilator, you're in much worse shape due to worse lung inflammation, and the dexa does more good.
My take, again: if you're on O2 no ventilator, your immune system is having some success, and if anything the steroid could hurt immune system.