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'Long Covid': Why are Some People not Recovering?

posted by Fnord666 on Monday October 12 2020, @02:59PM   

takyon writes:

'Long Covid': Why are some people not recovering?

For most people, Covid-19 is a brief and mild disease but some are left struggling with symptoms including lasting fatigue, persistent pain and breathlessness for months.

The condition known as "long Covid" is having a debilitating effect on people's lives, and stories of being left exhausted after even a short walk are now common.

So far, the focus has been on saving lives during the pandemic, but there is now a growing recognition that people are facing long-term consequences of a Covid infection.

Yet even basic questions - such as why people get long Covid or whether everyone will fully recover - are riddled with uncertainty.

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Original Submission

• Re:These are symptoms of scurvy Re:These are symptoms of scurvy (Score: 1, Informative) by Anonymous Coward on Monday October 12 2020, @03:51PM (5 children)

  by Anonymous Coward on Monday October 12 2020, @03:51PM (#1063583)

  Vitamin D is also an antioxidant that gets depleted the same way:

  Vitamin D is a membrane antioxidant: thus Vitamin D3 (cholecalciferol) and its active metabolite 1,25-dihydroxycholecalciferol and also Vitamin D2 (ergocalciferol) and 7-dehydrocholesterol (pro-Vitamin D3) all inhibited iron-dependent liposomal lipid
  peroxidation.

  https://pubmed.ncbi.nlm.nih.gov/8325381/ [nih.gov]

  Compared with several well-known antioxidants, vitamin D3 may be one of the most powerful antioxidants in biological organisms as shown in the present study.

  https://pubmed.ncbi.nlm.nih.gov/16179538/ [nih.gov]

  Wouldnt be surprised if vitamin c was responsible for recycling vitamin d just like for vitamin e.

  Parent

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• Re:These are symptoms of scurvy Re:These are symptoms of scurvy (Score: 0) by Anonymous Coward on Monday October 12 2020, @04:32PM (4 children)

  by Anonymous Coward on Monday October 12 2020, @04:32PM (#1063601)

  Vitamin C recycles vitamin E:

  Vitamin C (ascorbic acid) and vitamin E (tocopherol) are central interacting components of
  the antioxidant defense system [1]. The interrelation between both vitamins is based on the ‘vitamin
  E recycling’: tocopherol reacts with a peroxyl radical to form a tocopheryl radical, which in
  turn is regenerated by vitamin C [2]. Although this interrelation has been demonstrated on an
  experimental level [3–6], the impact of the interrelation between both vitamins on the biomarker level
  in community-dwelling subjects and particularly in the course of ageing remains to be shown.

  Our study demonstrates a robust positive interrelation between vitamins C and E status in
  community-dwelling elderly subjects during the course of advanced ageing, even in subjects not
  taking supplements. It is well known that α-tocopherol and ascorbic acid act synergistically in
  counteracting free radicals where α-tocopherol is able to quench free radicals in a hydrophobic
  environment and the resulting tocopherol radical is then regenerated by ascorbic acid [56]. Most of
  this evidence is based on animal and in-vitro studies [3,4,6] and studies investigating this relationship
  in vivo are scarce. One study providing pharmacological doses of either vitamin C or E to a group
  of healthy middle-aged adults for six weeks showed an increase in fasting plasma ascorbic acid
  after supplementation with α-tocopherol and an increased vitamin E status after ascorbic acid
  supplementation [5]. In another intervention study, pharmacological doses of vitamin C for two
  weeks attenuated fractional disappearance rates of plasma α- and γ-tocopherol in smokers, indicating
  that plasma vitamin C reduces α- and γ-tocopheroxyl radicals resulting from oxidative stress due
  to smoking [57].

  https://pubmed.ncbi.nlm.nih.gov/32992851/ [nih.gov]

  Vitamin D is probably similar, or is perhaps downstream from vitamin E in the membranes. Most people just study the role of the vitamin D receptor and don't consider it as an antioxidant.

  Parent

  • Re:These are symptoms of scurvy Re:These are symptoms of scurvy (Score: -1, Offtopic) by Anonymous Coward on Tuesday October 13 2020, @06:00AM (3 children)

    by Anonymous Coward on Tuesday October 13 2020, @06:00AM (#1063896)

    So if I eat vitamin C gummies, I can also start smoking again? Can we start a petition for Albanese to make vitamin C gummy worms?

    Parent

    • Re:These are symptoms of scurvy (Score: 0) by Anonymous Coward on Tuesday October 13 2020, @01:28PM

      by Anonymous Coward on Tuesday October 13 2020, @01:28PM (#1063967)

      Vitamin c gummies are probably worthless because the glucose competes for absorption via GLUT transporters. I think those gummies are like 40:1 molar glucose to ascorbate ratio iirc.

      Parent

    • Re:These are symptoms of scurvy (Score: 0) by Anonymous Coward on Wednesday October 14 2020, @02:21PM

      by Anonymous Coward on Wednesday October 14 2020, @02:21PM (#1064452)

      +1 for Albanese gummy worms

      Parent

    • Re:These are symptoms of scurvy (Score: 2) by The Mighty Buzzard on Thursday October 15 2020, @02:51PM

      by The Mighty Buzzard (18) <themightybuzzard@proton.me> on Thursday October 15 2020, @02:51PM (#1064988) Homepage Journal

      If they're sugar free, you should live stream the next few days.

      --
      My rights don't end where your fear begins.

      Parent