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I think the biggest changes we'll see in the short term probably involve how the pandemic is handled. I really expect two things here:

1) Biden will provide clear and consistent guidance to the governors and actually lead. Trump has pretty much declined to lead and provided inconsistent guidance, leaving a messy patchwork of policies at the state level. States complained that they don't have the resources they need. I expect Biden will be better here.

2) Scientists will be free to provide guidance again and it will be welcome. Dr. Fauci will be taken seriously by the new administration. He'll be allowed to freely speak to the press. For that matter, the Biden administration would listen to climate scientists, too.

That said, I suspect DeathMonkey was referring to the election results. Biden is now ahead in Georgia and Pennsylvania. That changed overnight. We'll need to wait and see Trump's response, but I can't imagine it'll be anything good.

As for the Senate, there's some hope, but Democrats will have to compromise with moderate Republicans. If it's 51-49 and Biden is president, Democrats really would just need Susan Collins to vote with them. Depending on the issue, they might be able to get support from a few other Republican senators like Lisa Murkowski, Mitt Romney, and perhaps a few other moderate senators. Rand Paul may side with the Democrats on a few issues. This helps with confirmations and a certain types of bills like the federal budget, but it almost certainly wouldn't allow Democrats to pack the courts or eliminate the filibuster on legislation. But short of having 60 Democrats in the Senate, something that was never realistic in this election, it was always going to take the nuclear option or compromise with moderate Republicans to advance a lot of legislation.