Stories
Slash Boxes
Comments

SoylentNews is people

posted by Fnord666 on Monday February 22, @01:20AM   Printer-friendly

A Genetic Variant You May Have Inherited From Neanderthals Reduces the Risk of Severe COVID-19:

[...] SARS-CoV-2, the virus that causes COVID-19, impacts people in different ways after infection. Some experience only mild or no symptoms at all while others become sick enough to require hospitalization and may develop respiratory failure and die.

Now, researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) in Japan and the Max Planck Institute for Evolutionary Anthropology in Germany have found that a group of genes that reduces the risk of a person becoming seriously ill with COVID-19 by around 20% is inherited from Neanderthals.

[...] Last year, Professor Svante Pääbo and his colleague Professor Hugo Zeberg reported in Nature[1] that the greatest genetic risk factor so far identified, doubling the risk to develop severe COVID-19 when infected by the virus, had been inherited from Neanderthals.

Their latest research builds on a new study, published in December last year from the Genetics of Mortality in Critical Care (GenOMICC) consortium in the UK, which [...] pinpointed additional genetic regions on four chromosomes that impact how individuals respond to the virus.

Now, in a study published recently in Proceedings of the National Academy of Sciences (PNAS)[2], Professor Pääbo and Professor Zeberg show that one of the newly identified regions carries a variant that is almost identical to those found in three Neanderthals – a ~50,000-year-old Neanderthal from Croatia, and two Neanderthals, one around 70,000 years old and the other around 120,000 years old, from Southern Siberia.

[...] To try to understand how this variant affects COVID-19 outcomes, the research team took a closer look at the genes located in this region. They found that three genes in this region, called OAS, code for enzymes that are produced upon viral infection and in turn activate other enzymes that degrade viral genomes in infected cells.

"It seems that the enzymes encoded by the Neanderthal variant are more efficient, reducing the chance of severe consequences to SARS-CoV-2 infections," Professor Pääbo explained.

[...] They found that the variant increased in frequency after the last Ice Age and then increased in frequency again during the past millennium. As a result, today it occurs in about half of people living outside Africa and in around 30% of people in Japan. In contrast, the researchers previously found that the major risk variant inherited from Neanderthals is almost absent in Japan.

"The rise in the frequency of this protective Neanderthal variant suggests that it may have been beneficial also in the past, maybe during other disease outbreaks caused by RNA viruses," said Professor Pääbo.

Obligatory, see also: Ozzy Osbourne's Genome Reveals Some Neandertal Lineage.

Journal References:
[1] Hugo Zeberg, Svante Pääbo. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals [open], Nature (DOI: 10.1038/s41586-020-2818-3)
[2] Hugo Zeberg, Svante Pääbo. A genomic region associated with protection against severe COVID-19 is inherited from Neandertals [open], Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.2026309118)


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: 3, Informative) by The Mighty Buzzard on Monday February 22, @04:55AM (20 children)

    That folks with darker skin are getting the worst of it is extremely widely known and reported. Here, have a citation from your own neck of the woods [thelancet.com]. Would you like a citation for clouds being made up of water vapor as well? How about one for soap and water being quite effective in making your ass smell better?

    --
    When responding to comments, please do not use phrases like "just how stupid can you be". Some take that as a challenge.
    Starting Score:    1  point
    Moderation   +2  
       Informative=2, Total=2
    Extra 'Informative' Modifier   0  

    Total Score:   3  
  • (Score: 2, Redundant) by c0lo on Monday February 22, @05:13AM (3 children)

    by c0lo (156) Subscriber Badge on Monday February 22, @05:13AM (#1115889) Journal

    Here, have a citation from your own neck of the woods [thelancet.com].

    Cited

    Indigenous Australians at increased risk of COVID-19 due to existing health and socioeconomic inequities

    Still shitposting so far. Give it another try, please.

    Would you like a citation for clouds being made up of water vapor as well? How about one for soap and water being quite effective in making your ass smell better?

    You make a claim, you provide citation.
    Otherwise, ignoring it as offtopic.

    --
    https://www.youtube.com/watch?v=aoFiw2jMy-0
    • (Score: 1) by The Mighty Buzzard on Tuesday February 23, @03:07PM (2 children)

      Correlation is not causation.

      Why is not a factor in correlation, only numbers are.

      --
      When responding to comments, please do not use phrases like "just how stupid can you be". Some take that as a challenge.
      • (Score: 2) by c0lo on Tuesday February 23, @04:04PM (1 child)

        by c0lo (156) Subscriber Badge on Tuesday February 23, @04:04PM (#1116463) Journal

        Correlation is not causation.

        Why is not a factor in correlation, only numbers are.

        And this is relevant how?

        Are you going to cite a paper that says "Genes regulating melanin have been correlated with covid prognosis in such and such way" in support for your "The genetics controlling the amount of melanin in the skin have a much higher correlation to case severity"?

        If not, go eff yourself, you're still shitposting.

        --
        https://www.youtube.com/watch?v=aoFiw2jMy-0
        • (Score: 2, Interesting) by The Mighty Buzzard on Friday February 26, @07:03PM

          You can do the math yourself. Genes controlling base melanin levels are correlated with race on a level of certainty way beyond high enough that you can simply use race as a proxy. Which leaves us with a statement that darker raced folks get more severe cases, on average. Which has had enough studies published saying exactly that to choke a horse and not a single reputable one saying they're incorrect.

          --
          When responding to comments, please do not use phrases like "just how stupid can you be". Some take that as a challenge.
  • (Score: 3, Insightful) by c0lo on Monday February 22, @05:21AM (11 children)

    by c0lo (156) Subscriber Badge on Monday February 22, @05:21AM (#1115890) Journal

    Reminder. Your claim that I'm waiting for citation is "The genetics controlling the amount of melanin in the skin have a much higher correlation to case severity."

    --
    https://www.youtube.com/watch?v=aoFiw2jMy-0
    • (Score: 2) by NateMich on Monday February 22, @12:55PM (6 children)

      by NateMich (6662) on Monday February 22, @12:55PM (#1115953)

      Reminder. Your claim that I'm waiting for citation is "The genetics controlling the amount of melanin in the skin have a much higher correlation to case severity."

      I think we all know that even if that were the case, nobody is going to report it that way.

      • (Score: 2) by c0lo on Monday February 22, @01:16PM

        by c0lo (156) Subscriber Badge on Monday February 22, @01:16PM (#1115961) Journal

        Seems TMB knows something that he doesn't want to make public, yes.

        --
        https://www.youtube.com/watch?v=aoFiw2jMy-0
      • (Score: 1, Insightful) by Anonymous Coward on Monday February 22, @02:30PM (4 children)

        by Anonymous Coward on Monday February 22, @02:30PM (#1115984)
        We have plenty of evidence that poverty, low income jobs, and unequal access to health care are what determines COVID infection and death rates. In other words, the outcome of racism, not genes.
        • (Score: 1, Insightful) by Anonymous Coward on Monday February 22, @05:45PM (3 children)

          by Anonymous Coward on Monday February 22, @05:45PM (#1116063)

          Of course poverty, and low income jobs are contributed to by genes. You can pretend we're all born equal under God, but somewhere in the back of your mind, some little inkling must fester, reminding you of the times some genetically unenlightened person has done what you expect some of some idiot to do. And then you begin maybe to think that perhaps, maybe, just maybe, there are other issues in the shallow end of the gene pool.

          • (Score: 0) by Anonymous Coward on Monday February 22, @08:04PM

            by Anonymous Coward on Monday February 22, @08:04PM (#1116130)

            Of course poverty, and low income jobs are contributed to by genes...

            You're, at best, talking about a fraction of a percent of the people affected by poverty.

          • (Score: 0) by Anonymous Coward on Tuesday February 23, @02:16PM (1 child)

            by Anonymous Coward on Tuesday February 23, @02:16PM (#1116409)
            >> “ Of course poverty, and low income jobs are contributed to by genes. You can pretend we're all born equal under God, but somewhere in the back of your mind, some little inkling must fester, reminding you of the times some genetically unenlightened person has done what you expect some of some idiot to do.”

            I give you Trump and QANON as counter-examples showing that whites can be far more stupid because of the privilege of being white giving them greater opportunity to do stupid without being called out on it.

            Watch “Hidden Figures “ it’s the true story of how a group of black women made it possible for America to get back into the space race through grit, determination, and sheer genius.

            • (Score: 0) by Anonymous Coward on Wednesday February 24, @11:36PM

              by Anonymous Coward on Wednesday February 24, @11:36PM (#1117030)

              "Watch “Hidden Figures “ it’s the true story of how a group of black women made it possible for America to get back into the space race through grit, determination, and sheer genius."

              What a dumb little bitch you are. You just lap up everything the Jew feeds you don't you?

    • (Score: 1) by The Mighty Buzzard on Tuesday February 23, @03:08PM (3 children)

      You had one. You just can't tell the difference between correlation and causation.

      --
      When responding to comments, please do not use phrases like "just how stupid can you be". Some take that as a challenge.
      • (Score: 2) by c0lo on Tuesday February 23, @03:58PM (2 children)

        by c0lo (156) Subscriber Badge on Tuesday February 23, @03:58PM (#1116459) Journal

        Foof, mate, you're shitposting again.
        From the citation you provided (have you read it?)

        Chronic disease rates are higher among Indigenous Australians living in remote areas, particularly hypertension and diabetes [5]. Marginalisation from health services, food insecurity, and poor access to water, sanitation, and adequate housing that accommodates larger family groups, amplify COVID-19 risk. Social distancing and self-isolation are unrealistic where more than one third of Indigenous Australians (41.4%) in remote areas live in inadequate housing conditions, compared to just 1.9% of non-Indigenous Australians.

        And this is just for you from the same source

        Comparatively, in the U.S, health, socioeconomic, and cultural inequities among Native Americans have contributed to their overrepresentation among COVID-19 cases [11]. Similar concerns have been expressed by Native American leaders, emphasising the limited capacity of the U.S Indian Health Service to respond to the pandemic due to a chronic lack of government funding, and restricted health infrastructure [12]. Exclusion of Native Americans from COVID-19 racial demographic data published by government health departments, has also been highlighted by Native American leaders as discriminatory and misleading, meanwhile restricting the ability of Indian Health Services to prepare and respond appropriately [12].

        I can guess the restricted health infrastructure impacts your ability to read.

        --
        https://www.youtube.com/watch?v=aoFiw2jMy-0
        • (Score: 1) by The Mighty Buzzard on Friday February 26, @07:07PM (1 child)

          Nothing you said contradicts anything I said. You just don't like that I'm correct, so you intentionally misread, misunderstand, and outright lie to yourself.

          Here is the only test to prove whether my claim is true or not: have dark folks had more severe cases of coronaids than less dark folks on average. And since you've found nothing whatsoever that disputes the absolute mountains of data around the world saying I am 100% correct, you need to just take the loss and move on.

          --
          When responding to comments, please do not use phrases like "just how stupid can you be". Some take that as a challenge.
          • (Score: 2) by c0lo on Friday February 26, @07:41PM

            by c0lo (156) Subscriber Badge on Friday February 26, @07:41PM (#1117683) Journal

            Mountain of evidence my ass.

            I'll let this convo drop, tho', it's a wasted time I can ill afford ATM.

            --
            https://www.youtube.com/watch?v=aoFiw2jMy-0
  • (Score: 0) by Anonymous Coward on Tuesday February 23, @01:18AM (3 children)

    by Anonymous Coward on Tuesday February 23, @01:18AM (#1116268)
    >> “ That folks with darker skin are getting the worst of it is extremely widely known and reported.”

    Blacks have gotten “the worst of it” for 400 years. Well before Covid. The higher illness and mortality rates of blacks have also been true for 400 years. Covid hasn’t been around for 400 years, but racial injustice certainly has.