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According to c|net, FDA panel gives Johnson & Johnson's one-shot COVID-19 vaccine green light:
An advisory panel for the US Food and Drug Administration has recommended Johnson & Johnson's single-dose COVID-19 vaccine be given the green light by the FDA. The FDA Vaccines and Related Biological Products Advisory Committee unanimously voted Friday afternoon to approve the vaccine.
The next step will be emergency approval from the FDA itself.
[...] In early February, a week after announcing that its single-dose vaccine was 66% effective overall in preventing COVID-19 in a global clinical trial, Johnson & Johnson submitted an application requesting the FDA grant emergency use authorization for the vaccine.
It would be the third vaccine on the US market, following the FDA granting emergency use authorization for the Pfizer and Moderna coronavirus vaccines in December, with vaccinations beginning just days later. Those vaccines are said to be 95% and 94% effective, respectively. Unlike the Pfizer and Moderna vaccines, Johnson & Johnson's vaccine requires only a single shot.
Earlier this month, President Joe Biden announced that the US is buying enough doses of Pfizer and Moderna COVID-19 vaccines to cover 300 million people in the country by the end of July -- though this doesn't mean everyone will be vaccinated by then.
"We've now purchased enough vaccine supply to vaccinate all Americans," Biden said. Actually administering the vaccines to all Americans could take longer because vaccinations are managed at a state and local level.
Here's where to get a COVID-19 shot, and here's how to track how many vaccines are available in your state.
MIT's Technology Review adds The one-shot vaccine from Johnson & Johnson now has FDA support in the US:
The new one-shot vaccine, called Ad26.COV2.S, was developed by Johnson & Johnson using work from Beth Israel Deaconess Medical Center in Boston. It employs a harmless viral carrier, adenovirus 26, which can enter cells but doesn't multiply or grow. Instead, the carrier is used to drop off gene instructions that tell a person's cells to make the distinctive coronavirus spike protein, which in turn trains the immune system to combat the pathogen.
The New York Times published a detailed graphical explanation of how the vaccine works.
Richard Nettles, vice president of US medical affairs at Janssen, a J&J subsidiary, told Congress during testimony on February 23 that production of the vaccine is "highly complex" and said the company was working to manufacture the shots at eight locations, including a US site in Maryland.
The manufacturing is complicated because the vaccine virus is grown in living cells before it is purified and bottled. Making a batch of virus takes two months, which is why there is no way to immediately increase supplies if timelines are missed.
[...] In late January, the company announced results from a 45,000-person study it carried out in the US, South Africa, and South America, in which people got either the vaccine or a placebo.
Overall, the vaccine was 66% effective in stopping covid-19, and somewhat better at stopping severe disease. In the trial, for instance, seven people died of covid-19, but all of these were in the placebo arm. Also, its effects increased with time—after a month, no one in the vaccine arm had to go to the hospital for covid-19.
[...] The J&J shot has fewer side effects than the mRNA vaccines and has also proved effective against a highly transmissible South African variant of the virus that has accumulated numerous mutations.
The South Africa variant has alarmed researchers because it clearly decreases the effectiveness of some vaccines. A study in South Africa by AstraZeneca found its vaccine didn't offer protection against the variant at all, causing officials to scrap a plan to distribute the shot there.
(Score: 0, Interesting) by Anonymous Coward on Wednesday March 03 2021, @03:40AM (3 children)
Life has a 100% fatality rate, COVID has a 99% survival rate.
(Score: 1, Insightful) by Anonymous Coward on Wednesday March 03 2021, @01:33PM (2 children)
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @04:21PM (1 child)
log covid? Is that when you roll over and find covid?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @04:58PM
(Score: -1, Troll) by fustakrakich on Wednesday March 03 2021, @03:41AM (11 children)
It turns them gay [forbes.com]
La politica e i criminali sono la stessa cosa..
(Score: -1, Offtopic) by Anonymous Coward on Wednesday March 03 2021, @07:38AM (1 child)
What if they are already homosexuals? Does the vaccine turn them straight and negate the gayness? Oh noes, y'alls just read this in my voice. Ohh nooo.
(Score: 2) by DannyB on Wednesday March 03 2021, @06:33PM
OMG, I think you just described a miracle cure!
I can see it now. Gay people will be lined up in droves to be "fixed" like cultists at an Apple store waiting on the new shiny.
What will the Pope say? (not that I care)
What would Trump say? (not that he can set policy any more)
Would a Dyson sphere [soylentnews.org] actually work?
(Score: 1, Interesting) by Anonymous Coward on Wednesday March 03 2021, @07:38AM (7 children)
I also heard a TV news blurb about some Catholic organization discouraging their parishioners from going for the J&J vaccine because it's manufacture employed cells from dead babies. I'd search for the details, but I'm sure there is somebody else more interested in doing so than I am.
--
Did anyone else read, "Bug Jack Barron"?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @12:17PM
I avoid technologies where its manufacture employed idiots who believe in imaginary sky beings.
(Score: 1) by fustakrakich on Wednesday March 03 2021, @05:03PM (3 children)
:-) Too bad you don't read. There was a link right there
La politica e i criminali sono la stessa cosa..
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @07:42PM (1 child)
Too bad you don't bait your links enticingly enough, nor summarize them sufficiently. I was trying to help a brother out by giving readers a notion that the parent post was perhaps worth more than a (Score:0, Informative) rating. Did I mention that I was not really interested?
(Score: 1) by fustakrakich on Wednesday March 03 2021, @07:55PM
:-) Odd way of showing it... Everybody else's lack of interest is much more obvious.
La politica e i criminali sono la stessa cosa..
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @07:51PM
...and am I the only one who can see the non-redundant and topically pertinent "Bug Jack Barron" reference?
A confederacy of dunces indeed!
(Score: 2) by DannyB on Wednesday March 03 2021, @06:35PM (1 child)
Question: were stem cells used in the manufacture of the vaccine or merely in its testing ?
Would a Dyson sphere [soylentnews.org] actually work?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @11:54PM
Manufacture. They use them like little protein factories.
(Score: 2) by cmdrklarg on Wednesday March 03 2021, @04:19PM
I was raised Catholic.
I got better.
Answer now is don't give in; aim for a new tomorrow.
(Score: -1, Offtopic) by Anonymous Coward on Wednesday March 03 2021, @03:46AM
s/t.
(Score: -1, Flamebait) by Anonymous Coward on Wednesday March 03 2021, @04:03AM (8 children)
Buffalo News ran a piece today which said the first 200 J&J vaccine doses coming to this area are mostly going to retired nuns. Article headline reads, "Nuns, other homebound to get Johnson & Johnson vaccine coming to Erie County."
(Score: 2, Flamebait) by Runaway1956 on Wednesday March 03 2021, @04:18AM (7 children)
Isn't this the same Johnson & Johnson who advised nuns (among other women) to insert talcum & asbestos into their vaginas?
Abortion is the number one killed of children in the United States.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @04:35AM (6 children)
Are you the same Runaway born in 1956? Or have you replaced all the original atoms in that original Runaway, in the course of your so-called "life".
You probably know that companies keep the same name for years, but the people turn over, divisions are bought and sold, and so on. So why the snark?
(Score: 2) by c0lo on Wednesday March 03 2021, @06:46AM (4 children)
Because the one and only Runaway1956 today has confessed in the past he's an asshole and proud of it.
He didn't repent and, as any assholes, it prone to projection.
Projection of bullshit and other kinds of shit, as well as other forms of projection.
https://www.youtube.com/watch?v=aoFiw2jMy-0
(Score: 2) by aristarchus on Wednesday March 03 2021, @09:11AM
Not just projection, but prolapse. Fatal in some cases. St Gregory of Tours recounts an evil Bishop who died on the privy from a prolapse of the rectum. I hope Runaway does not strain too much.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @12:33PM (2 children)
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @01:39PM
They also sell a bunch of products containing PEG, so they probably don't want people becoming allergic. Pfizer and moderna don't care
Unfortunately this vaccine also contains the double proline mutation, but it is otherwise likely much better than the mRNA ones. Astrazeneca does not have that mutation but it is not available in the US.
(Score: 2) by c0lo on Wednesday March 03 2021, @04:08PM
I don't remember to have ever said that snark/assholes and having a point are mutually exclusive.
Even when the point is shitty.
https://www.youtube.com/watch?v=aoFiw2jMy-0
(Score: 2) by sjames on Wednesday March 03 2021, @08:45AM
Because corporate culture and ethics often change more slowly than the people. Each new person gets a soulectomy and indoctrination as they come in. By the time the next person is replaced the second newest person is fully absorbed. In that way, the evil can last for many generations.
(Score: 0, Offtopic) by gtomorrow on Wednesday March 03 2021, @06:22AM (3 children)
At this reading, five out of six total comments are moderated as such, in order:
Posted for posterity's sake. Is this a SoylentNews record?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @06:48AM
There, have another one in your list. If you are to be honest, at least this one is entirely on merit.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @09:13AM
No? New here, aren't you? But from your id #, maybe just have not checked in, for a while.
(Score: 2) by Aegis on Wednesday March 03 2021, @03:25PM
We get a lot of antivaxxer lies around these parts.
Personally. I'm gonna wait until AFTER I get my jab(s) to resume disputing them. Shorter line for me!
(Score: 4, Interesting) by Beryllium Sphere (r) on Wednesday March 03 2021, @08:01AM (20 children)
A single shot means no more headaches of getting people back for dose 2 and handling them properly if they've moved. The simplification is a game changer by itself, and it is a superb fit to all sorts of populations. Jail inmates might be out on bail or time-served before it was time for a second dose. Homeless people are almost by definition hard to locate and the police keep forcing them to move. Commercial oceangoing fishermen may be unreachable for dose 2. Migrant farmworkers stand to benefit too.
Then there's the ability to ship to every little mom and pop pharmacy with a refrigerator.
This is wonderful, and for those who haven't been tracking closely, the effectiveness numbers are closer than the headlines make it sound. The Johnson and Johnson vaccine got tested after the resistant variants came out. For keeping you out of the hospital or the morgue it's as effective as the mRNA vaccines.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @12:41PM (14 children)
It’s a shit vaccine. 66% effective. AstraZeneca 62% effective - and zero against at least one variant. Given a choice between vaccines that are 94 and 95% effective and this shit, which would any sane person pick?
The crap vaccines will guarantee profits far into the future since 1/3 of people vaccinated with them will continue to get infected, and infect others. What a scam by government regulators.
And not just in the US.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @01:39PM
Ding ding ding!...we have a winner!...
(just don't tell everyone, ok?)
I spotted something in passing online a couple of days back, maybe apocryphal, paraphrased, it ran as follows; somone in Britain talking on the phone to a friend in Brazil about the 'Brazilian strain' now 'at large' in the UK, only to be asked 'Is that like the British strain we have Over here?'
(Score: 1, Insightful) by Anonymous Coward on Wednesday March 03 2021, @01:41PM (11 children)
You realize you are comparing various different measures of effectiveness right? Some of those numbers refer to testing positive, others to symptoms, etc.
(Score: 1, Insightful) by Anonymous Coward on Wednesday March 03 2021, @02:13PM (10 children)
I only know one person who will accept the AZ or j&J vaccines. We’ll wait.
(Score: -1, Troll) by Anonymous Coward on Wednesday March 03 2021, @02:16PM (4 children)
Ok, well the moderna and pfizer studies didnt check whether people got infected. So that 95% does not refer to the number that counts.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @05:12PM (3 children)
And now AstraZeneca for the African vaccine - 0%.
Africa won’t be using the AstraZeneca vaccine. Nova Scotia is refusing any shipments, so it’s not just the 3D world. Other Canadian provinces are refusing to use the AZ vaccine for over-65s. And people are demanding that everyone have access to the Pfizer and Moderna vaccines. With elections in the air, the government will cave. People are tired of being manipulated by others trying to make shitty 3rd stage results look good enough when they aren’t anywhere near competitive.
And to try to claim that real world results are better is an admission that the AZ 3rd tier was defective and the whole thing needs to be redone. The Oxford/AstraZeneca vaccine process was deeply infected with political manipulation. It’s not only Purdue University that shits out crap for money.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @06:35PM (2 children)
Why are you insisting on comparing numbers that use different definitions of effectiveness?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @10:49PM (1 child)
It’s a dud. Sure, it’s cheaper, but in this case you get what you pay for.
(Score: 0) by Anonymous Coward on Thursday March 04 2021, @04:40AM
It is just incorrect to compare rate of symptoms vs rate of testing positive as if they are the same thing.
(Score: 1, Interesting) by Anonymous Coward on Wednesday March 03 2021, @03:01PM (2 children)
I don't know where to start...
leading to..
Now, where are you getting the idea that the mRNA concoctions actually prevent you getting infected? the mRNA things prevent you from, as you (and the CDC) say, '..getting sick..' from the infection, and lessen the chances of any nasty long term effects, but they don't prevent infection, nor do they stop you from passing the fun on..
They're a most useful capitalist 'vaccine' in that respect, I fully expect new mRNA 'vaccines' every couple of years now to deal with newer, scarier variants of this 'Al Quaeda of the virus world', for a supposed global health emergency where we're all supposedly in it together, there are a lot of people making obscene profits directly out of it and the theatre surrounding it..and let's not get into the wider political aspects...'temporary' (aye, right! temporary, my arse...) draconian laws, 'vaccination passports' etc. etc. It's been every little authoritarians wet dreams all come at once.
Again, like the actual Covid death figures, there's a lot to argue about regarding the actual caused of 'Long Covid', but, having had Covid (March 2020) I can say things have been a bit weird since, so, in my case, 'Long Covid' is....weird. The most pernicious aspects of it so far have been the bloody insomnia and eyesight weirdies..my vision ain't what it was 12 months ago.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @05:28PM (1 child)
Smarten up. A successful infection requires enough cells being infected that the immune system can’t completely suppress it after exposure.
You can’t be infected by a single viral particle. Even the most virulent pathogen known doesn’t work that way.
The AZ and JJ vaccines say that they will reduce, but NOT eliminate, the infection in 1:3 of the population. Mild to moderate infection is their own term - and people with mild to moderate infections are transmitters.
If I’m around someone with a cold, and the virus fails to gain a foothold because my immune system kills it off, I can’t give it to anyone. I’m simply not shedding virus because I’m not producing virus.
Think of it - people who are immune to other diseases because their body reacts properly to a vaccine don’t transmit a. Otherwise we’d still be dealing with millions of smallpox cases every year. If you can’t become infected, you can’t transmit it. If you can get infected, you will transmit it. There’s no exception known. Just people who are infected but asymptomatic or pre-symptomatic - and in both cases they are most certainly infected.
Some people can be re-infected. The same crappy immune system that let them get infected the first time strikes again. But most people who’ve been infected will be immune. Some for a period of time, some forever. YMMV depending entirely on your immune system. Vaccines don’t always work, same as being infected doesn’t always work to provide immunity.
(Score: 1) by shrewdsheep on Thursday March 04 2021, @02:16PM
To nitpick, the contrary is true. Your infection - most likely - will precisely be the clone of a single infectious unit. OTOH, you have the concept of number of infectious units stating that there is an average number leading to the infection rate of 50% of test-subjects, implying that every unit increases the probability of infection. Turning back to the individual, when getting exposed to a number of infectious units, most will not lead to infection (getting stuck in nose-hair etc.). Some will enter cells but not replicate. In the end there is a single unit (well, likely) that successfully replicates.
(Score: 2) by FatPhil on Wednesday March 03 2021, @03:38PM (1 child)
Never heard of Mary Mallon?
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @05:32PM
(Score: 0, Insightful) by Anonymous Coward on Wednesday March 03 2021, @03:39PM
Given that none of these treatments have been properly tested, none.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @03:25PM (2 children)
If the MMR vaccine was as ineffective as this piece of overhyped crap we’d have continued research to find something else because we’d have millions still dying
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @04:18PM (1 child)
We delay the second shot because there'd be no point to a second shot if they're back to back. You'd just double the size of the injection. Yes, you do get some benefit from the first dose, but that's not why they can space three doses, they space the doses to give the body time to adjust in the meantime.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @05:35PM
(Score: 2) by FatPhil on Wednesday March 03 2021, @03:43PM (1 child)
However, we do need the final real-world test to be sure. Sleeves up!
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @10:52PM
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @01:50PM (5 children)
"Some adenoviruses under specialized conditions can transform cells using their early gene products. E1A (binds Retinoblastoma tumor suppressor protein) has been found to immortalize primary cells in vitro allowing E1B (binds p53 tumor suppressor) to assist and stably transform the cells. Nevertheless, they are reliant upon each other to successfully transform the host cell and form tumors. "
https://en.wikipedia.org/wiki/Adenoviridae [wikipedia.org]
"Tumor viruses come in a variety of forms: Viruses with a DNA genome, such as adenovirus, and viruses with an RNA genome, like the hepatitis C virus (HCV), can cause cancers, as can retroviruses having both DNA and RNA genomes (Human T-lymphotropic virus and hepatitis B virus, which normally replicates as a mixed double and single-stranded DNA virus but also has a retroviral replication component). In many cases, tumor viruses do not cause cancer in their native hosts but only in dead-end species. For example, adenoviruses do not cause cancer in humans but are instead responsible for colds, conjunctivitis and other acute illnesses. They only become tumorigenic when infected into certain rodent species, such as Syrian hamsters."
https://en.wikipedia.org/wiki/Oncovirus [wikipedia.org]
There are several other Wikipedia articles worth reading on this but what about the animal species that the vaccine adenovirus vector originated from? Does it cause cancer in those? If so could it then cause cancer in humans? Why or why not? Is this something that would show up in 90 days?
It should also be noted that various DNA viruses have been associated with tumors (Adenoviruses, Papilloma viruses, and SV40).
Any thoughts?
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @02:00PM (1 child)
We will have lots of field data on this soon. Then we will, know if that is a risk.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @03:29PM
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @08:56PM
The medical purposes of the vaccine push are to cause sterility and cancer. All about population control, especially in western/white nations. The UK is even giving non-white invaders exemptions from vaccine mandates.
(Score: 0) by Anonymous Coward on Friday March 05 2021, @05:53AM (1 child)
I'm going to try and keep things simple. In vaccines like these, there is the payload and the vector. The SARS-CoV-2 spike protein sequence is encoded as the payload as a DNA sequence. That sequence is purposely designed to be missing restriction and recombination sites, not that the Killer T cells would let the cell live long enough that is an issue. It is therefore unlikely to cause long-term issues because any disease state created by the vaccine will be unable to spread to other cells nor will it cause long-term changes in healthy cells.
The payload is the replication-incompetent Ad26 virus. That is just a shell to carry the DNA payload and was chosen for a number of properties, one of which is its epitopical contrast to endogenous proteins. This means that autoimmune and other diseases are also unlikely to be an issue because it doesn't look like anything in the body and is unable to make copies of itself.
So basically, there is not a high likelihood of cancers or chronic diseases because these are designed to avoid those things. Wild viruses have no such concerns and can cause larger and chronic changes to cells that these vaccines are not capable of doing.
(Score: 0) by Anonymous Coward on Friday March 05 2021, @05:57AM
Should have proofread that again. The DNA is the payload. The Ad26 virus "shells" are the vector. Regardless, neither is likely to be a problem in terms of your question, but you may develop permanent vector immunity. Whether that is a problem depends on your point of view.
(Score: 0) by Anonymous Coward on Wednesday March 03 2021, @04:58PM
Presumptive 'social offender' suspects are gonna wind up OD'ed on state-mandated Sildenafil, instead of a COVID-19 vaccine.
(Score: -1, Troll) by Anonymous Coward on Wednesday March 03 2021, @08:52PM
""We've now purchased enough vaccine supply to vaccinate all Americans," Biden said."
good luck with that, you re-animated corpse.
(Score: 2) by quietus on Thursday March 04 2021, @08:52PM
I see a lot of US this and US that in the sources on which the write-up is based. May I just point out that the vaccine was developed by a subsidiary with its headquarters in Belgium? [wikipedia.org]
Just needed to get my daily xenophobic rant off my chest, thank you, thank you & here all day.