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posted by Fnord666 on Wednesday June 09 2021, @06:41PM   Printer-friendly
from the did.you.take.the.pill.or.not? dept.

The FDA has approved a new drug for Alzheimer's disease, while not a cure it is supposed to slow the decline. Even though data is not entirely positive or straight forward in its interpretation or that it will actually even work as thought.

But if you have it then you are probably desperate enough to try almost anything that claims to work, until you get to the price tag of $56,000 per year. That will probably make it out of reach for most people, it's doubtful if any insurance will cover something like this. Perhaps you can just forget to pay the bill, they might understand due to your condition.

Biogen CEO Michel Vounatsos [...][said] he thought the drug's price was "fair" but also vowed that the company would not hike its price for four years.

https://www.cnbc.com/2021/06/07/fda-approves-biogens-alzheimers-drug-the-first-new-therapy-for-the-disease-in-nearly-two-decades.html

Previously:
In Surprise Turnaround, Biogen to Submit Previously Failed Alzheimer Drug for Approval
Disputed Alzheimer's Study Links Decrease in Amyloid Levels to Reduction in Cognitive Decline
Positive Result in Mice as Alzheimer's Drug Trials Fail and Regulatory Barriers Are Rolled Back


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  • (Score: 4, Interesting) by pdfernhout on Thursday June 10 2021, @02:37AM

    by pdfernhout (5984) on Thursday June 10 2021, @02:37AM (#1143776) Homepage

    Top hits DDG searching on "alzheimer's sleep nutrition":
    https://nutritionreview.org/2019/01/sleep-deprivation-accelerates-alzheimers-brain-damage/ [nutritionreview.org]
    https://pubmed.ncbi.nlm.nih.gov/30413973/ [nih.gov]
    "Certain aspects of nutrition can decrease risk for dementia. Physical activity has also been associated with delayed or slower age-related cognitive decline. In addition, emerging evidence links sleep dysfunction and dementia, with amyloid deposition being a possible mediator. Data from further clinical trials are needed before more definitive conclusions can be drawn regarding the efficacy of these lifestyle interventions for lowering the risk of incident dementia and cognitive decline. Nevertheless, it is reasonable to make recommendations to our patients to adopt certain dietary changes and to engage in regular physical activity to improve cardiovascular risk factors for dementia. It is also reasonable to include questions on sleep during cognitive evaluations of the elderly, given the common co-occurrence of sleep dysfunction and cognitive impairment in the elderly population."

    And searching on the MEND protocol I'd previously heard of:
    https://newsroom.ucla.edu/releases/memory-loss-associated-with-alzheimers-reversed-for-first-time [ucla.edu]
    "Memory loss associated with Alzheimer’s reversed for first time: Small trial by UCLA and Buck Institute succeeds using ‘systems approach’ to memory disorders"

    "The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age"
    https://www.amazon.com/End-Alzheimers-Program-Protocol-Cognition/dp/0525538496 [amazon.com]

    From the UCLA item:
    ====
    “The existing Alzheimer’s drugs affect a single target, but Alzheimer’s disease is more complex. Imagine having a roof with 36 holes in it, and your drug patched one hole very well,” he said. “The drug may have worked, and a single hole may have been fixed, but you still have 35 other leaks, and so the underlying process may not be affected much.”

    Bredesen’s approach is personalized to the patient, based on extensive testing to determine what is affecting the brain’s plasticity signaling network. In the case of the patient with the demanding job who was forgetting her way home, her therapy consisted of some, but not all, of the components of Bredesen’s program, including:

            eliminating all simple carbohydrates, gluten and processed food from her diet, and eating more vegetables, fruits and non-farmed fish
            meditating twice a day and beginning yoga to reduce stress
            sleeping seven to eight hours per night, up from four to five
            taking melatonin, methylcobalamin, vitamin D3, fish oil and coenzyme Q10 each day
            optimizing oral hygiene using an electric flosser and electric toothbrush
            reinstating hormone replacement therapy, which had previously been discontinued
            fasting for a minimum of 12 hours between dinner and breakfast, and for a minimum of three hours between dinner and bedtime
            exercising for a minimum of 30 minutes, four to six days per week

    Bredesen said the program’s downsides are its complexity and that the burden falls on patients and caregivers to follow it. In the study, none of the patients was able to stick to the entire protocol. Their most common complaints were the diet and lifestyle changes, and having to take multiple pills each day.

    The good news, though, said Bredesen, are the side effects: “It is noteworthy that the major side effects of this therapeutic system are improved health and an improved body mass index, a stark contrast to the side effects of many drugs.”

    The results suggest that memory loss may be reversed and improvement sustained with the therapeutic program, but Bredesen cautioned that the results need to be replicated.

    “The current, anecdotal results require a larger trial, not only to confirm or refute the results reported here, but also to address key questions raised, such as the degree of improvement that can be achieved routinely, how late in the course of cognitive decline reversal can be effected, whether such an approach may be effective in patients with familial Alzheimer’s disease, and last, how long improvement can be sustained,” he said.
    ====

    I've also seen comments about people sensitive to mold (given tighter houses). Also, consider that pesticides were developed from nerve gas...

    Given you are going to be exposed to some toxins no matter what you do, at least you can give yourself a fighting chance by optimizing yoru health by good nutrition and good sleep and exercise and so on. Related:
    "Fat, Sick & Nearly Dead" (and its sequel)
    https://www.youtube.com/watch?v=q1z5WjjVL5c [youtube.com]
    "Overweight, loaded up on steroids and suffering from a debilitating autoimmune disease, Joe Cross was at the end of his rope and the end of his hope. With doctors and conventional medicine unable to help, Joe traded in junk food and hit the road with a juicer and generator in tow, vowing only to drink fresh fruit and vegetable juice for 60 days. Across 3,000 miles Joe had one goal in mind: To get off his pills and achieve a balanced lifestyle."

    --
    The biggest challenge of the 21st century: the irony of technologies of abundance used by scarcity-minded people.
    Starting Score:    1  point
    Moderation   +2  
       Interesting=2, Total=2
    Extra 'Interesting' Modifier   0  
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    Total Score:   4