Stories
Slash Boxes
Comments

SoylentNews is people

posted by martyb on Wednesday July 21 2021, @08:55PM   Printer-friendly

New approach eradicates breast cancer in mice:

CHAMPAIGN, Ill. -- A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

[...] "Even when a few breast cancer cells do survive, enabling tumors to regrow over several months, the tumors that regrow remain completely sensitive to retreatment with ErSO," said U. of I. biochemistry professor David Shapiro, who led the research with Illinois chemistry professor Paul Hergenrother. "It is striking that ErSO caused the rapid destruction of most lung, bone and liver metastases and dramatic shrinkage of brain metastases, since tumors that have spread to other sites in the body are responsible for most breast cancer deaths," Shapiro said.

[...] ErSO is nothing like the drugs that are commonly used to treat estrogen-receptor-positive cancers, Shapiro said.

"This is not another version of tamoxifen or fulvestrant, which are therapeutically used to block estrogen signaling in breast cancer," he said. Even though it binds to the same receptor that estrogen binds, it targets a different site on the estrogen receptor and attacks a protective cellular pathway that is already turned on in cancer cells, he said.

[...] "Many of these breast cancers shrink by more than 99% in just three days," Shapiro said. "ErSO is fast-acting and its effects on breast cancers in mice are large and dramatic."

The pharmaceutical company Bayer AG has licensed the new drug and will explore its potential for further study in human clinical trials targeting estrogen-receptor-positive breast cancers, the researchers said. The researchers will next explore whether ErSO is effective against other types of cancers that contain estrogen receptor.

Journal Reference:
Matthew W. Boudreau, Darjan Duraki, Lawrence Wang, et al. A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice [$], Science Translational Medicine (DOI: 10.1126/scitranslmed.abf1383)


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
  • (Score: 1, Flamebait) by fakefuck39 on Thursday July 22 2021, @01:27AM (3 children)

    by fakefuck39 (6620) on Thursday July 22 2021, @01:27AM (#1158980)

    licensing can be ok. frand is a good example. this one unfortunately is not
    "this new deal will now give Bayer the exclusive rights to develop the compound"

    "U. of I. biochemistry professor David Shapiro"
    let's see here. U of I. That's in my state. Subsidized by my state taxes.

    investors in the company are
    The Pritzker Organization
    Lakeshore Capital Thailand

    The Pritzkers, of the Hyatt fame, are one of the wealthiest families in the US, worth about $30bil.

    Now, what does Systems Oncology actually do to come up with these miraculous cures? They buy lots and lots of compute and storage - that's the reason I know of them. They load up that storage with huge caches of public datasets from all kinds of sources, most of the data obtained using public funds, and use "AI" to come up with possible drugs to treat different things.

    Then they come up with a candidate in the computer model, test it out, and if it works, patent it and give exclusive rights to big companies known for ripping people off and most famously sell heroin as cough medicine. Well, no, I'd say this one is more famous for torture and nazi medical experiments on people - selling heroin cough syrup would be it's secondary famous thing.

    Now, I wonder if they could hook up with the log(lgbtqxyz16^e*pi)+ group with the happy flag, collect some data, and come up with a cure for being faggots. then they should take that medicine, and then they should work on cancer drugs.

    Starting Score:    1  point
    Moderation   -1  
       Flamebait=1, Total=1
    Extra 'Flamebait' Modifier   0  
    Karma-Bonus Modifier   +1  

    Total Score:   1  
  • (Score: -1, Troll) by Anonymous Coward on Thursday July 22 2021, @03:50AM (1 child)

    by Anonymous Coward on Thursday July 22 2021, @03:50AM (#1159012)

    Um, so investment is BAD. No.... good. Definitely good. Or bad. Got it, face fuck.

    • (Score: 1, Troll) by fakefuck39 on Thursday July 22 2021, @04:37AM

      by fakefuck39 (6620) on Thursday July 22 2021, @04:37AM (#1159029)

      strange, i said zero about investment here, yet your eyes are seeing text about investments. you should probably get that checked out at the doctor's. go to the same one that gave you the pills to keep your autism in check, since it's not the vision, it's the genetically defective brain tissue.

  • (Score: -1, Spam) by Anonymous Coward on Thursday July 22 2021, @06:39PM

    by Anonymous Coward on Thursday July 22 2021, @06:39PM (#1159179)

    "Nazi" is an anti-white Jew slur. Fuck you, lying Jew!