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$15 drug gets COVID patients off oxygen support in under week – study:
Fourteen out of 15 severe COVID-19 patients who were treated in an investigator-initiated interventional open-label clinical study of the drug TriCor (fenofibrate)[*] didn't require oxygen support within a week of treatment and were released from the hospital, according to the results of a new Hebrew University of Jerusalem study.
Fenofibrate is an FDA-approved oral medication. The results were published on Researchsquare.com and are currently under peer review.
Specifically, the team that was led by HU's Prof. Yaakov Nahmias carried out the study at Israel's Barzilai Medical Center in coordination with the hospital's head of the Infectious Disease Unit, Prof. Shlomo Maayan, and with support from Abbott Laboratories.
[...] The 15 treated patients all had pneumonia and required oxygen support. They were also older with multiple comorbidities, ranging from diabetes and obesity to high blood pressure.
"The results were dramatic," Nahmias told The Jerusalem Post. "Progressive inflammation markers, which are the hallmark of deteriorative COVID-19, dropped within 48 hours of treatment. Moreover, 14 of the 15 severe patients didn't require oxygen support within a week of treatment." The 15th patient was off oxygen within 10 days.
When looking at the data on other similar severe patients, less than 30% of them on average are removed from oxygen support within a week. In other words, fenofibrate could dramatically shorten the treatment time for severe COVID patients.
"We know these kinds of patients deteriorate really fast, develop a cytokine storm in five to seven days and that it can take weeks to treat them and for them to get better," Nahmias said. "We gave these patients fenofibrate and the study shows inflammation dropped incredibly fast. They did not seem to develop a cytokine storm[**] at all."
Cytokine storms are aggressive inflammatory responses to illness.
[*] Fenofibrate entries on MedlinePlus and Wikipedia.
[**] Cytokine storm on Wikipedia.
Journal Reference:
Yaakov Nahmias, Avner Ehrlich, Konstantinos Ioannidis, et al. Metabolic Regulation of SARS-CoV-2 Infection, (DOI: 10.21203/rs.3.rs-770724/v1)
(Score: 5, Funny) by Opportunist on Saturday August 28 2021, @09:31PM (24 children)
No longer we need bleach and deworming agents, we have a new champion!
(Score: 1, Interesting) by Anonymous Coward on Saturday August 28 2021, @09:50PM (23 children)
At least this one has a proposed mechanism of action and appears to work at sane doses. This study isn't perfect but I've seen people throw around worse. But if the actual doctors end up using it, does that mean the anti-vaxxers won't? I mean, they don't know the side effects and can't trust big pharma...
(Score: 1, Interesting) by Anonymous Coward on Saturday August 28 2021, @10:04PM (10 children)
Hello Martian, fancy to see you in Earth Internet!
Here on planet Earth, those of us who prefer to survive, tend to rely on word of mouth. People we know who recovered from this or that disease, recommend to us the doctors who treated them, and/or the medicines they used for the treatment. Those of us who lack medical knowledge of their own, also consult with relatives or friends who do have some.
Do things work totally differently on Mars?
(Score: 2) by Tork on Sunday August 29 2021, @12:04AM
I think he was asking about those people who apparently know Willy Wonka, Kermit the Frog, and Jim Halpert.
🏳️🌈 Proud Ally 🏳️🌈
(Score: 5, Insightful) by Opportunist on Sunday August 29 2021, @12:35AM (6 children)
Oh please, boomer, get with the times. You don't rely on relatives, today you turn to YouTubers and Twitter for medical advice.
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @11:28AM (4 children)
Pfft YouTube and Twitter are sooo MySpace grandpa, now we use TikTok for our needs.
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @04:55PM (3 children)
OMG tiktoc your soooo old what ru lik 19 or somethng?
(Score: 1) by pTamok on Sunday August 29 2021, @06:12PM (2 children)
So fake. Anyone investigating youth culture knows they don't use punctuation - its regarded as rude.
(Score: 2) by Opportunist on Monday August 30 2021, @09:19AM (1 child)
Then why do you use it boomer we have identified you because anyone chill these days uses run on sentences without period or comma which makes the whole crap really hard to read if you happen to know a thing or two about grammar but then who does because ... damn this message is too long doesn't fit in a tweet anymore
(Score: 1) by pTamok on Monday August 30 2021, @08:45PM
Samuel Beckett was obviously chill: How it is (1964) (Comment c'est) is entirely without punctuation for 147 pages.
It's cute watching young people believe they are doing something new.
(Score: 2) by DannyB on Monday August 30 2021, @02:01PM
And legal advice.
Universal health care is so complex that only 32 of 33 developed nations have found a way to make it work.
(Score: 2) by driverless on Sunday August 29 2021, @05:18AM (1 child)
It's not their mouths that most of the people providing Covid advice in places like FB are talking out of...
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @04:57PM
Word of ass?
(Score: 2) by JoeMerchant on Saturday August 28 2021, @10:48PM
Me, personally, my blood panel suggests that I might try to reduce my triglycerides anyway... the primary "side effect" of using Fenofibrate to head off a cytokine storm would likely be it's primary intended use: reduction of serum levels triglycerides and cholesterols.
🌻🌻 [google.com]
(Score: 5, Insightful) by Anonymous Coward on Sunday August 29 2021, @12:43AM (10 children)
Correct!
There is one thing I have come to understand about right-wingers: they love death. They love weapons. They love spreading misinformation about life-saving technologies. Hell, they even love mistaking their own misinformation for truth! The more death the better!
I expect the Christian mullahs to start quoting Bible passages from the archaic and otherwise problematic anyway KJV that show why the devil will eat your soul if you take this medicine instead of bleach injections or hydroxychloroquine. I heard that fenofibrate will make men grow breasts faster than soy. Etc, etc.
Well, maybe. The only thing that's really certain is that this won't be a $15 drug for much longer. And I guess we just live with this being endemic. After all, if you catch it, you just have to get a few $10,000 injections of TriCor™ and you'll be fine.
Shit. That means I have to start working from the office again soon.
(Score: -1, Insightful) by Anonymous Coward on Sunday August 29 2021, @01:16AM (3 children)
There is one thing I have come to understand about lefties: you love lying.
That one thing is enough to completely disregard all the spam you produce.
The height of hilarity is, you are all too dumb to understand the fact.
(Score: 2) by Tork on Sunday August 29 2021, @04:29PM (2 children)
Well you got a point there... you lot definitely have failed to prove that "fact".
🏳️🌈 Proud Ally 🏳️🌈
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @08:24PM (1 child)
Well, you here have proven all three points just perfectly in one sentence. Thanks!
(Score: 2) by Tork on Sunday August 29 2021, @09:01PM
🏳️🌈 Proud Ally 🏳️🌈
(Score: 1, Insightful) by Anonymous Coward on Sunday August 29 2021, @01:54AM (4 children)
Who do you think JK Rowling modelled Lord Voldemort and the Death Eaters on? Yes, the British conservative party. Maggie, "Let them eat Spotted Dick" Thatcher, and company. And now, Eric Clapton. Right-wingers do not just love death, they are death, destroyers of worlds! Look upon their Stupid, and despair!
(Score: 0, Troll) by Anonymous Coward on Sunday August 29 2021, @02:37AM (2 children)
I see your masters have now put Eric Clapton on the hate list. Was his participation in "Stand and Deliver" last year not sufficient to trigger the unpersoning?
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @03:22PM
Eric Clapton put himself on the "I'm a racist beyond hope of reasoning with" list a very long time ago. Rock Against Racism was formed in 1976, mostly in response to his very visible, very public, very amplified racist rantings to large audiences.
(Score: 2) by epitaxial on Monday August 30 2021, @12:39PM
"Not just leave the hall, leave our country... I don't want you here, in the room or in my country," he said in part.
"The Black w—s and c—s and Arabs and f—ing Jamaicans don't belong here, we don't want them here," Clapton added on stage then, using blatant racist slurs. "This is England, this is a white country, we don't want any Black w—s and c—s living here. We need to make clear to them they are not welcome."
The rant went on as he called England "a white country" made "for white people."
(Score: 0) by Anonymous Coward on Sunday August 29 2021, @05:01PM
Eric Claptout should be grateful for any social media mentions whatsoever. For you non-boomers out there, he was an old guitarist that your grandparents may have listened to on the gramophone.
(Score: 4, Insightful) by Anonymous Coward on Sunday August 29 2021, @04:05AM
Well, that outhouse to at least keep the incels off the streets and busy playing with their new toys …
Seriously though, as much as they bitch and moan about the latest vaccine mandates, it's mostly performative - after they've bitched and moaned enough they're going to get the shots rather than lose their jobs and being barred from most places. Just like they moved the goalposts when the FDA gave full appoval to the vaccines, they'll move them sideways to claim some sort of "we resisted as long as humanly possible " rather than admit they were wrong. But expect a lot of fake side effects and malingering.