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$15 drug gets COVID patients off oxygen support in under week – study:
Fourteen out of 15 severe COVID-19 patients who were treated in an investigator-initiated interventional open-label clinical study of the drug TriCor (fenofibrate)[*] didn't require oxygen support within a week of treatment and were released from the hospital, according to the results of a new Hebrew University of Jerusalem study.
Fenofibrate is an FDA-approved oral medication. The results were published on Researchsquare.com and are currently under peer review.
Specifically, the team that was led by HU's Prof. Yaakov Nahmias carried out the study at Israel's Barzilai Medical Center in coordination with the hospital's head of the Infectious Disease Unit, Prof. Shlomo Maayan, and with support from Abbott Laboratories.
[...] The 15 treated patients all had pneumonia and required oxygen support. They were also older with multiple comorbidities, ranging from diabetes and obesity to high blood pressure.
"The results were dramatic," Nahmias told The Jerusalem Post. "Progressive inflammation markers, which are the hallmark of deteriorative COVID-19, dropped within 48 hours of treatment. Moreover, 14 of the 15 severe patients didn't require oxygen support within a week of treatment." The 15th patient was off oxygen within 10 days.
When looking at the data on other similar severe patients, less than 30% of them on average are removed from oxygen support within a week. In other words, fenofibrate could dramatically shorten the treatment time for severe COVID patients.
"We know these kinds of patients deteriorate really fast, develop a cytokine storm in five to seven days and that it can take weeks to treat them and for them to get better," Nahmias said. "We gave these patients fenofibrate and the study shows inflammation dropped incredibly fast. They did not seem to develop a cytokine storm[**] at all."
Cytokine storms are aggressive inflammatory responses to illness.
[*] Fenofibrate entries on MedlinePlus and Wikipedia.
[**] Cytokine storm on Wikipedia.
Journal Reference:
Yaakov Nahmias, Avner Ehrlich, Konstantinos Ioannidis, et al. Metabolic Regulation of SARS-CoV-2 Infection, (DOI: 10.21203/rs.3.rs-770724/v1)
(Score: 5, Interesting) by JoeMerchant on Sunday August 29 2021, @12:59PM
HIPAA protects health information of individuals from spreading, your political leaders are "shaping" the aggregate information that is released to protect their agendae.
HIPAA doesn't do anything about information that individuals choose to release. We have several friends-of-friends who have contracted COVID (presumably delta) in spite of being fully vaccinated, some report mild symptoms, some severe, I believe one or two hospitalized.
The reasonable number I have heard is that the Pfizer vaccine confers an 8x increase in immune response, on average. So: in a population of 100,000 fully vaccinated, you should expect transmission rates, severe cases, hospitalizations and deaths to be approximately 1/8th of what they would be in a population of 100,000 unvaccinated. In a population of 100,000 that is 1/2 fully vaccinated and 1/2 not, that translates to an R value of approximately 0.56x the R value of an unvaccinated population - which would have been good enough to stop the original COVID strain, but doesn't seem good enough for delta.
The thing I'm super-pissed about the whole episode is: if we had taken social distancing, masking, WFH, lockdown, etc. seriously a month earlier, and kept it serious until the vaccination rollout was 40% or better, I don't think we'd even have a delta variant, at least not until many years later than we got it.
🌻🌻 [google.com]