Stories
Slash Boxes
Comments

SoylentNews is people

posted by janrinok on Thursday January 13, @10:07AM   Printer-friendly
from the Watching-What-You-Eat dept.

Scientists Have Discovered Unexpected Benefits of Fat in Type 2 Diabetes:

With nearly 10% of the world's population affected, type 2 diabetes is a major public health issue. An excessively sedentary lifestyle and a too-caloric diet encourage the development of this metabolic disease by altering the functioning of pancreatic cells and making blood sugar regulation less effective. However, fat, which is often cited as the ideal culprit, could be rehabilitated. Indeed, fat does not necessarily aggravate the disease and could even play a protective role: by studying insulin-producing pancreatic beta cells, scientists from the University of Geneva (UNIGE), Switzerland, have shown that these cells suffered less from excess sugar when they had previously been exposed to fat. By investigating the cellular mechanisms at work, the researchers discovered how a cycle of fat storage and mobilization allows cells to adapt to excess sugar. These results, published in the journal Diabetologia, highlight an unexpected biological mechanism that could be used as a lever to delay the onset of type 2 diabetes.

Type 2 diabetes results from a dysfunction of pancreatic beta cells, which are responsible for insulin secretion. This impairs the regulation of blood sugar levels and can lead to serious heart, eye, and kidney complications. In the 1970s, fat was singled out and the concept of lipotoxicity emerged: exposure of beta cells to fat would cause their deterioration. More recently, excess sugar has also been blamed for damaging beta cells and promoting the development of type 2 diabetes. However, while the culpability of sugar is no longer in doubt, the role of fat in beta cell dysfunction remains ambiguous. What are the cellular mechanisms involved? "To answer this key question, we studied how human and murine beta cells adapt to an excess of sugar and/or fat", explains Pierre Maechler, a Professor in the Department of Cell Physiology and Metabolism and in the Diabetes Centre of the UNIGE Faculty of Medicine, who led this work.

[...] By further analyzing the cellular changes at stake, the research team realised that fat droplets were not static reserves, but were the site of a dynamic cycle of storage and mobilization. And thanks to these released fat molecules, beta cells adapt to the excess sugar and maintain a near-normal insulin secretion.

Journal Reference:
Lucie Oberhauser, Cecilia Jiménez-Sánchez, Jesper Grud Skat Madsen, et al. Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells, Diabetologia (DOI: 10.1007/s00125-021-05633-x)


Original Submission

 
This discussion has been archived. No new comments can be posted.
Display Options Threshold/Breakthrough Mark All as Read Mark All as Unread
The Fine Print: The following comments are owned by whoever posted them. We are not responsible for them in any way.
(1)
  • (Score: 5, Insightful) by crafoo on Thursday January 13, @10:23AM (14 children)

    by crafoo (6639) on Thursday January 13, @10:23AM (#1212382)

    (animal) fat good energy source. sugar baaaaad; poison.

    Modern food is a real bummer. Poison and actual food are sold side-by-side and people are expected to make rational, objective, long-term decisions about their health while they are being sold poison and told it's just the best stuff ever. over and over and over again. emotionally manipulated.

    Just stop eating processed foods. If it comes in a box or a bag, or has more than 2 or 3 ingredients, just don't buy it.

    • (Score: 2, Informative) by Anonymous Coward on Thursday January 13, @01:54PM (12 children)

      by Anonymous Coward on Thursday January 13, @01:54PM (#1212404)

      Yes, low fat, high carb diets cause obesity. Of course that is what the government recommends.

      Refined sugar is not even a food, it is a drug like caffeine and cocaine that gets put into nearly everything today. If you read about fasting for lent hundreds of years ago, sugar didn't count. People knew it wasn't food.

      • (Score: 1, Funny) by Anonymous Coward on Thursday January 13, @01:57PM (6 children)

        by Anonymous Coward on Thursday January 13, @01:57PM (#1212405)

        > If you read about fasting for lent hundreds of years ago, sugar didn't count. People knew it wasn't food.

        I certainly go to religious people from the 18th century for all my dietary recommendations.

        • (Score: 1, Touché) by Anonymous Coward on Thursday January 13, @02:32PM

          by Anonymous Coward on Thursday January 13, @02:32PM (#1212412)

          I go to corporations trying to sell me something.

        • (Score: 0, Insightful) by Anonymous Coward on Thursday January 13, @02:54PM (3 children)

          by Anonymous Coward on Thursday January 13, @02:54PM (#1212415)

          People in the past mostly ate food that they had been eaten for centuries, if not millennia. It was known to sustain them. It will sustain us now. And speaking of the 18th century and sugar, that was a new addition to the Western diet. European colonies in the West Indies were pumping out tons of sugar at affordable prices while making an absolute killing in profits for the plantation owners. You could consider this the first case of an introduced fake food for profit in the Western diet.

          You would be better off eating what your country grandma ate than what's in a box at the supermarket. The rise of convenience food trash (whether take out or heated up at home) in our diet is a direct consequence of women having jobs outside the home. There are few home cooked from scratch meals anymore due to lack of time and also energy. Another result of feminism for society, unfortunately.

          • (Score: 2) by hendrikboom on Thursday January 13, @07:48PM (2 children)

            by hendrikboom (1125) Subscriber Badge on Thursday January 13, @07:48PM (#1212497) Homepage Journal

            Were I to buy just one lettuce to use in a salad, I get a few salads out of it before it goes bad. And the grocery store sells them in bags of three. I just can't buy food that knows where it comes from in small enough portions!

            • (Score: 0) by Anonymous Coward on Thursday January 13, @10:10PM (1 child)

              by Anonymous Coward on Thursday January 13, @10:10PM (#1212534)

              All I can suggest is splitting groceries with someone else. Outside of that, I've got nothing.

              • (Score: 0) by Anonymous Coward on Friday January 14, @06:22PM

                by Anonymous Coward on Friday January 14, @06:22PM (#1212724)

                Hydroponics. If you're wasting as much lettuce as the gp, even a small aerogarden would pay for itself over the course of a year or two.

        • (Score: 2) by HammeredGlass on Thursday January 13, @08:25PM

          by HammeredGlass (12241) on Thursday January 13, @08:25PM (#1212511)

          Our forebears would have stumbled across a few nuggets of wisdom over the centuries, if for no other reason than it was easier.

      • (Score: 2) by HiThere on Thursday January 13, @03:09PM

        by HiThere (866) on Thursday January 13, @03:09PM (#1212421) Journal

        If you read about mideval religious fasts, the Friday abstenance from meat in Ireland did not include wild geese, as they were considered a kind of fish. (Hence the terms "barnacle goose" and "goose barnacle".) An I believe in South America the Capybara was also considered a fish.

        Also look up the history of the word "carnival" (hint: "carne vale")

        --
        Javascript is what you use to allow unknown third parties to run software you have no idea about on your computer.
      • (Score: 1, Insightful) by Anonymous Coward on Thursday January 13, @05:49PM (3 children)

        by Anonymous Coward on Thursday January 13, @05:49PM (#1212449)

        I don't know about the Lent thing, but I am given to understand that sugar was considered a seasoning. On Antique's Roadshow they actually had a several hundred year old spice case. The bottles still had spices in them, and there was also a sugar cone. I had always expected sugar cones to be bigger. It was two inches high. The host explained that such cones were extremely valuable, and that the cook would use something like a file to get a little sugar dust off the cone.

        Of course that eventually changed. The infamous Triangular Trade circulated slaves to the Caribbean, who were forced to produce sugar and ultimately economies of scale gave us the casual choice of "one lump or two", those infamous British teeth, and American Type-2 diabetes epidemics.

        As others have pointed out, cheap sugar (or these days, corn based analogs) are so cheap that they're sneaked in as an additive wherever possible. I've struggled with this myself recently--having tested high for trigylcerides and been asked "are you a sugar addict". I said "no" but when I went home I audited all my stuff and realized the bread and yogurt were really doing me in. The "fruit" in the yogurt is really fruit and sugar. The bread has sugar in addition to the carbs I knew I was getting.

        Since then, I've cut way back and I feel better. I'm waiting for that next check-up to see what the numbers are.

        Fuck added sugar.

        • (Score: 1, Insightful) by Anonymous Coward on Thursday January 13, @06:24PM

          by Anonymous Coward on Thursday January 13, @06:24PM (#1212459)

          If you haven't already, start by cutting back on the obvious sources of sugar and substitute foods with less added sugar and it gets better. Trying anything more drastic probably won't work.

        • (Score: 3, Insightful) by hendrikboom on Thursday January 13, @07:50PM

          by hendrikboom (1125) Subscriber Badge on Thursday January 13, @07:50PM (#1212498) Homepage Journal

          I buy yoghurt without fruit and add any fruit myself.

        • (Score: 1, Insightful) by Anonymous Coward on Thursday January 13, @09:57PM

          by Anonymous Coward on Thursday January 13, @09:57PM (#1212530)

          Cereals. The staple American breakfast.

          Instant Poison.

    • (Score: 2, Informative) by Anonymous Coward on Thursday January 13, @07:42PM

      by Anonymous Coward on Thursday January 13, @07:42PM (#1212495)

      'Sugar' = is composed of dextrose and fructose

      Fructose component is far worse for the body than dextrose, as fructose is metabolised by the liver alone.

      High fructose corn syrup (because of corn subsidies) is an all to commonly used sweetener.

(1)