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Revolutionary DNA Nanotechnology Speeds Up Development of Vaccines by More Than One Million Times:
In search of pharmaceutical agents such as new vaccines, industry will routinely scan thousands of related candidate molecules. A novel technique allows this to take place on the nano scale, minimizing use of materials and energy. The work is published in the prestigious journal Nature Chemistry.
More than 40,000 different molecules can be synthesized and analyzed within an area smaller than a pinhead. The method, developed through a highly interdisciplinary research effort in Denmark, promises to drastically reduce the amounts of material, energy, and economic cost for pharmaceutical companies.
The method works by using soap-like bubbles as nano-containers. With DNA nanotechnology, multiple ingredients can be mixed within the containers.
"The volumes are so small that the use of material can be compared to using one liter of water and one kilogram of material instead of the entire volumes of water in all oceans to test material corresponding to the entire mass of Mount Everest. This is an unprecedented save in effort, material, manpower, and energy," illustrates head of the team Nikos Hatzakis, Associate Professor at the Department of Chemistry, University of Copenhagen.
"Saving infinitely amounts of time, energy and manpower would be fundamentally important for any synthesis development and evaluation of pharmaceuticals," says PhD Student Mette G. Malle, lead author of the article, and currently Postdoc researcher at Harvard University, USA.
[...] The SPARCLD method (single particle combinatorial lipidic nanocontainer fusion based on DNA mediated fusion) is a parallelized, multi-step and non-deterministic fusion of individual zepto-liter nano-containers. The research team has observed efficient (more than 93 %) leakage-free fusion sequences for arrays of surface tethered target liposomes with six freely diffusing populations of cargo liposomes, each functionalized with individual lapidated DNA (LiNA) and fluorescent barcoded by distinct ratio of chromophores. Stochastic fusion results in distinct permutation of fusion sequences for each autonomous nano-container. Real-time total internal reflection (TIRF) microscopy allowed direct observation of more than 16,000 fusions and accurate classification of 566 distinct fusion sequences using Machine Learning. The method allows for approximately 42,000 nano-containers per square millimeter.
Journal Reference:
Malle, Mette Galsgaard, Löffler, Philipp M. G., Bohr, Søren S.-R., et al. Single-particle combinatorial multiplexed liposome fusion mediated by DNA, Nature Chemistry (DOI: 10.1038/s41557-022-00912-5)
(Score: -1, Troll) by Anonymous Coward on Tuesday April 05 2022, @01:20PM (1 child)
speed up "proof of function" research?
Asking for a Russian/Chinese friend.
(Score: 1, Touché) by Anonymous Coward on Tuesday April 05 2022, @05:08PM
Finally a moron comprehends that Russia is NOT their friend. Being a Fox Viewer this will not last long and they'll soon be demanding Ukraine be handed over to Russia.
(Score: 2) by HiThere on Tuesday April 05 2022, @01:28PM
This may allow the rapid repurposing of existing drugs (even that's not certain), but it won't shortcut the testing for safety. It's shortcutting a process that's already not the rate-limiting step.
That said. it should drastically improve both the cost and the speed of certain phases of the development. It doesn't allow testing for safety or effectiveness to proceed any faster, and that's usually the rate limiting step. (Actually, it sounds as if it might do some rapid eliminations, but it can't do any rapid approvals.)
Caution: I am not a biochemist or other kind of medic. (OTOH, I'd really be surprised if I'm wrong about this.)
Javascript is what you use to allow unknown third parties to run software you have no idea about on your computer.
(Score: 4, Informative) by ikanreed on Tuesday April 05 2022, @01:28PM
Pragmatically, no.
When the mRNA vaccines for covid were developed initially, the challenging problem wasn't that we couldn't synthesize the chemistry needed for them. It was that the spike protein that was the most ideal target for anti-body development was extremely toxic itself, and they had to determine what modifications would make it inert, but still morphologically analogous.
So you could spin up something like this and call it a day, but there's so much real basic work to do with understanding diseases in-context that mere production process improvements aren't particularly notable.
(Score: 1, Insightful) by Anonymous Coward on Tuesday April 05 2022, @04:09PM
"The overall performance improvement gained by optimizing a single part of a system is limited by the fraction of time that the improved part is actually used."
https://en.wikipedia.org/wiki/Amdahl%27s_law#:~:text=In%20computer%20architecture%2C%20Amdahl's%20law,system%20whose%20resources%20are%20improved. [wikipedia.org]
Given that most of the time spent creating a vaccine seems to be testing it to see if it is safe and effective, I foresee relatively modest improvements to time-to-market for new vaccines.
(Score: 2) by krishnoid on Tuesday April 05 2022, @09:10PM
When actual, lab-reproducible science talks about stuff like this, can you blame people? "Sure, being able to get a health check with a drop of blood, sounds great! And totally not ridiculous. I'd definitely like to invest in your venture, Ms. Elizabeth Holmes."