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posted by hubie on Saturday November 18 2023, @06:31PM   Printer-friendly
from the Aging dept.

Research suggests that your body may enjoy an exercise routine more than you do:

If you've ever started a new exercise plan or diet, you'll most likely have been told many times that consistency is the key to reaching goals. Now, scientists for the first time have found that sticking to a daily routine of when you work out could be just as important for bone and joint health.

A study out of The University of Manchester has looked at internal body clocks to see how exercising at the same time of day can potentially shield against bone and joint deterioration, protecting against injury and stave off age-related physical decline and associated conditions such as arthritis.

"Among the many health challenges, the age-related musculoskeletal decline – and its adverse consequences – is a major burden to individuals," said senior author Judith Hoyland, and spine/intervertebral disk expert from The University of Manchester. "We have identified a new clock mechanism underlying skeletal aging, which could have far-reaching impacts on understanding frailty and designing more efficient treatment timing of exercise and physiotherapy to maintain good skeletal health and mobility."

[...] "The daily 24-hour cycle that our bodies follow, such as our internal temperature dropping when we sleep and our blood pressure rising at certain times of day, is known as our circadian rhythm," said Lucy Donaldson, Director of Research & Health Intelligence at collaborating organization Versus Arthritis. "There are processes inside our body which keep this rhythm going, known as 'clocks,' which are all linked to our central body clock in the brain."

Studies have shown that if those other clocks are out of whack with our central timekeeper, it presents a higher risk of many health conditions including cardiovascular disease. Research suggests fat cells have their own biological clock, and the cardiovascular system's own ticker may explain the prevalence of morning heart attacks.

Now, for the first time, University of Manchester researchers have unlocked the mechanisms that make the body's intervertebral disk and cartilage clocks tick. With no nerves nor blood supply, until now it has not been entirely clear that the brain's circadian timekeeping is able to sync up with these unique body clocks.

[...] "And our work showed that clocks in skeletal tissues of older animals remain responsive to daily patterns of exercise," he added. "As such, walking groups organized for older people could be more beneficial for their health if they happen at a similar time every day."

[...] "We already know that exercise is one of the best ways to reduce the pain and impact of arthritis, and this very early research shows that exercising at certain times of day might bring added benefits for people with arthritis," said Donaldson. "This is an important discovery because it could help us to develop more targeted treatments for musculoskeletal conditions such as arthritis using exercise and physical activity."

Journal Reference:
Dudek, M., Pathiranage, D.R.J., Bano-Otalora, B. et al. Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks. Nat Commun 14, 7237 (2023). https://doi.org/10.1038/s41467-023-42056-1


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  • (Score: 1, Interesting) by Anonymous Coward on Sunday November 19 2023, @03:24AM

    by Anonymous Coward on Sunday November 19 2023, @03:24AM (#1333479)

    In a mouse model, the scientists made mice exercise on a treadmill during what would usually be their resting time, to demonstrate how unpredictable activity results in an acceleration of bone and cartilage deterioration.

    Making mice exercise during their resting time is not the same as making mice exercise at different times of their normal waking hours.

    And were the mice sleep deprived too?

    All I can take from this is don't jog/run in the middle of your normal sleeping hours unless you have to.

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