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posted by on Wednesday March 04 2015, @01:35PM   Printer-friendly
from the giving-mice-e.-coli dept.

ScienceMag.org reports that salt is preferentially deposited at the site of skin wounds.

Scientists only recently learned that the connective tissue of skin can serve as a reservoir for sodium ions when we consume large amounts of salt. When Jens Titze, a clinical pharmacologist at the Vanderbilt University School of Medicine in Nashville was studying dietary salt intake in mice, he noticed that even mice on low-salt diets had unusually high salt concentrations in wounded skin. Titze and his colleagues realized that immune cells arriving in wounded skin to fight infections were entering a salty microenvironment. They hypothesized that the body was shuffling salt to infected skin to protect against invaders.

The scientists wondered if the higher salt concentration near wounds might affect immune responses, so they cultured macrophages from mice, and added salt to raise the level to what they saw in skin near wounds. They then challenged the macrophages with a common infectious agents.

Salt increased the microbe-killing capacity of the immune cells, the team reports; the macrophages exposed to high levels of sodium chloride released significantly more microbicidal molecules than those that grew in a culture medium without salt. Next, the team infected macrophages with the common pathogens Escherichia coli or Leishmania major. After 24 hours, the E. coli load in macrophages exposed to high sodium chloride levels was less than half of that of macrophages cultured without salt, and L. major infections were down as well.

The effect was seen even in salt levels found in mice on low-salt diets. They then went on to compare the effect in mice fed either a high or low salt diet, and found that the higher salt mice fought infections much better.

They also caution that there may be better ways to increase salt in the skin than adding it to your diet, such as applying it to wounds directly as part of the treatment.

 
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  • (Score: 2) by pnkwarhall on Wednesday March 04 2015, @09:42PM

    by pnkwarhall (4558) on Wednesday March 04 2015, @09:42PM (#153255)

    Not so much anymore they don't :)

    Honestly, as soon as I posted that comment I realized the manufacturer could just add a topical analgesic (or whatever they're called) to the ointment.

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  • (Score: 0) by Anonymous Coward on Thursday March 05 2015, @11:32AM

    by Anonymous Coward on Thursday March 05 2015, @11:32AM (#153469)

    Our studies show Market demand for cocaine laced salty water and ointments would be very high indeed.

  • (Score: 2) by urza9814 on Thursday March 05 2015, @01:55PM

    by urza9814 (3954) on Thursday March 05 2015, @01:55PM (#153493) Journal

    Nobody would buy it because it might sting a bit? I dunno about that -- how many people clean their wounds with rubbing (or perhaps drinking) alcohol? That's certainly what I always use. The only people I know who keep Neosporin around are people with little kids.

    And you could make a killing marketing this stuff to the hippies. Bottle seawater and brand it as "VEGAN! ORGANIC! ALL-NATURAL! NON-TOXIC! CHEMICAL-FREE!"...although actually, those might not all be true if it's ocean water ;)

    • (Score: 2) by pnkwarhall on Thursday March 05 2015, @02:17PM

      by pnkwarhall (4558) on Thursday March 05 2015, @02:17PM (#153499)

      Poor hippies, they're so easily took. Not like everybody else.

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      Lift Yr Skinny Fists Like Antennas to Heaven