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Hugh Pickens writes:

Nico Pitney reports that the urban poor in the United States are experiencing accelerated aging at the cellular level, and that chronic stress linked both to income level and racial-ethnic identity is driving this physiological deterioration. Researchers analyzed telomeres, tiny caps at the ends of DNA strands that protect cells from aging prematurely, of poor and lower middle-class black, white, and Mexican residents of Detroit and found that low-income residents of Detroit, regardless of race, have significantly shorter telomeres than the national average. "There are effects of living in high-poverty, racially segregated neighborhoods -- the life experiences people have, the physical exposures, a whole range of things -- that are just not good for your health," says Nobel laureate. Dr. Arline Geronimus, the lead author of the study, described as the most rigorous research of its kind examining how "structurally rooted social processes work through biological mechanisms to impact health." White Detroit residents who were lower-middle-class had the longest telomeres in the study. But the shortest telomeres belonged to poor whites. Black residents had about the same telomere lengths regardless of whether they were poor or lower-middle-class. And poor Mexicans actually had longer telomeres than Mexicans with higher incomes. Geronimus says these findings demonstrate the limitations of standard measures -- like race, income and education level -- typically used to examine health disparities. "We've relied on them too much to be the signifiers of everything that varies in the life experiences of difference racial or ethnic groups in different geographic locations and circumstances."

One co-author of this new study is Dr. Elizabeth Blackburn who helped to discover telomeres, an achievement that won her the Nobel Prize in physiology in 2009. Blackburn ticked off a list of studies in which people's experiences and perceptions directly correlated with their telomere lengths: whether people say they feel stressed or pessimistic; whether they feel racial discrimination towards others or feel discriminated against; whether they have experienced severely negative experiences in childhood, and so on. "These are all really adding up in this quantitative way," says Blackburn. "Once you get a quantitative relationship, then this is science, right?"