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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism:
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8.
Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
tl;dr: ibuprofen can reduce testosterone production and interfere with fertility.
(Score: 2, Funny) by Ethanol-fueled on Tuesday January 01 2019, @04:13AM (2 children)
Then fucking stump it and then chain the stump to the back of your Cummins Turbo Diesel and rip it out. Every day you don't, that Willow tree is just laughing at you and thinks you're a pussy. He's telling all his tree friends that you're a pussy, and when your bitch sits under him he tells her the same thing after she rubs his branches off. Open your curtains and look at him. So you see him pointing at you and laughing, and hear his mocking cries in your sleep?
(Score: 2, Informative) by Sulla on Tuesday January 01 2019, @04:54AM
>achieving any sort of thing with a dodge
Thanks for the laugh +1 funny
Ceterum censeo Sinae esse delendam
(Score: 2) by JoeMerchant on Wednesday January 02 2019, @01:11AM
For Brazilian pepper, I cut it down 3 times in 2 years, finally got it by pouring 2 cycle engine fuel into the raw / drilled to a cup stump.
🌻🌻🌻 [google.com]