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Electronic devices that dissolve completely in water, leaving behind only harmless end products, are part of a rapidly emerging class of technology pioneered by researchers at the University of Illinois at Urbana-Champaign. Early results demonstrate the entire complement of building blocks for integrated circuits, along with various sensors and actuators with relevance to clinical medicine, including most recently intracranial monitors for patients with traumatic brain injury. The advances suggest a new era of devices that range from green consumer electronics to ‘electroceutical’ therapies, to biomedical sensor systems that do their work and then disappear.