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The US Food and Drug Administration has issued a new ruling on a category of drugs known as NSAIDs (nonsteroidal anti-inflammatory drugs), strengthening the label warnings that taking the medications increases the risk of heart attacks and strokes. NSAIDs include both prescription drugs and popular over-the-counter medications, including ibuprofen (sold under brand names including Advil and Motrin) and naproxen (brands include Aleve). NSAIDs reduce the body's production of prostaglandins, compounds which may play a role in inflammation.
The new warning guidelines stop well short of recommending that mostly-healthy people not to use NSAIDs, partly because the science isn't settled. Some doctors already report that patients are confused by the new advisories.
Aspirin is also an NSAID, but was specifically excluded from the FDA advisory. Acetaminophen, another popular drug for pain relief (e.g. Tylenol), is not an NSAID, but some researchers have cautioned that studies show correlations between heavy acetaminophen use and early mortality and other adverse medical effects.
Original Submission
(Score: 2) by tathra on Monday July 13 2015, @04:00AM
the only physiological change caused by opioid use is the unbinding of G proteins from their respective receptors (which can be undone with the use of opioid antagonists, which cause the G proteins to re-bind). opioids will not cause mental illness or anything like that at any higher rate than anything else; in fact, opioids are the safest of all medications and recreational drugs.
(Score: 0) by Anonymous Coward on Monday July 13 2015, @05:51AM
Do people build tolerance to opioids?
There are many feedback loops in biology. That is why many medications require steping-down the dose. Long term treatment may cause a change in sensitivity or the number of G proteins.