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Title    Mechanism Behind Most Common Form of Inherited Alzheimer's Disease Revealed
Date    Thursday March 05 2015, @02:06PM
Author    janrinok
Topic   
from the I've-forgotten-what-I-was-going-to-write dept.
https://soylentnews.org/article.pl?sid=15/03/05/080239

n1 writes:

ScienceDaily reports:

A study from researchers at Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) reveals for the first time exactly how mutations associated with the most common form of inherited Alzheimer's disease produce the disorder's devastating effects. Appearing in the March 4 issue of Neuron, the paper upends conventional thinking about the effects of Alzheimer's-associated mutations in the presenilin genes and provides an explanation for the failure of drugs designed to block presenilin activity.
[...]
"Our study provides new insights into Alzheimer's disease by showing how human mutations that cause the disease lead to neurodegeneration and dementia," says Raymond J. Kelleher III, MD, PhD, of the MGH Department of Neurology and Center for Human Genetic Research, co-senior author of the Neuron paper. "We found that mutations in the presenilin-1 gene promote the hallmark features of the disease by decreasing, rather than increasing, function of the presenilin-1 protein and the gamma-secretase enzyme. In addition to the important therapeutic implications of our findings, we have also generated the first animal model in which an Alzheimer's-disease-causing mutation produces neurodegeneration in the cerebral cortex."

Links

  1. "n1" - https://soylentnews.org/~n1/
  2. " ScienceDaily reports" - http://www.sciencedaily.com/releases/2015/03/150304130911.htm

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