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Title    New Tool for Optogenetics: Photocleavable Proteins
Date    Monday March 20, @11:42AM
Author    Fnord666
Topic   
from the there's-a-light dept.
https://soylentnews.org/article.pl?sid=17/03/18/1728232

takyon writes:

Researchers have created a protein that breaks into two pieces when exposed to light:

Researchers at the University of Alberta have developed a new method of controlling biology at the cellular level using light. The tool -- called a photocleavable protein -- breaks into two pieces when exposed to light, allowing scientists to study and manipulate activity inside cells in new and different ways.

First, scientists use the photocleavable protein to link cellular proteins to inhibitors, preventing the cellular proteins from performing their usual function. This process is known as caging. "By shining light into the cell, we can cause the photocleavable protein to break, removing the inhibitor and uncaging the protein within the cell," said lead author Robert Campbell, professor in the Department of Chemistry. Once the protein is uncaged, it can start to perform its normal function inside the cell. The tool is relatively easy to use and widely applicable for other research that involves controlling processes inside a cell.

Optogenetic control with a photocleavable protein, PhoCl (DOI: 10.1038/nmeth.4222) (DX)

Related: With a Better Optogenetic Light Switch, Scientists Can Flip Neurons On and Off
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Nerve Stimulation May Recover Memories in Alzheimer's Patients (Mice)
Scientists Test a Way to Erase Scary Memories
Mice Turned Violent by Photoactivation of Amygdala Neurons


Original Submission

Links

  1. "takyon" - https://soylentnews.org/~takyon/
  2. "a protein that breaks into two pieces when exposed to light" - https://www.ualberta.ca/science/science-news/2017/march/biochemists-develop-new-way-to-control-cell-biology-with-light
  3. "Robert Campbell" - https://www.ualberta.ca/science/about-us/contact-us/faculty-directory/robert-campbell
  4. "Department of Chemistry" - https://www.ualberta.ca/chemistry/
  5. "Optogenetic control with a photocleavable protein, PhoCl" - http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.4222.html
  6. "DX" - http://dx.doi.org/10.1038/nmeth.4222
  7. "With a Better Optogenetic Light Switch, Scientists Can Flip Neurons On and Off" - https://soylentnews.org/article.pl?sid=15/08/23/034254
  8. "Gene Therapy Human Trial Will Inject Virus Into the Retinas of the Legally Blind" - https://soylentnews.org/article.pl?sid=16/02/29/2043215
  9. "Nerve Stimulation May Recover Memories in Alzheimer's Patients (Mice)" - https://soylentnews.org/article.pl?sid=16/03/18/1512231
  10. "Scientists Test a Way to Erase Scary Memories" - https://soylentnews.org/article.pl?sid=16/05/13/1059223
  11. "Mice Turned Violent by Photoactivation of Amygdala Neurons" - https://soylentnews.org/article.pl?sid=17/01/12/2158252
  12. "Original Submission" - https://soylentnews.org/submit.pl?op=viewsub&subid=19148

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printed from SoylentNews, New Tool for Optogenetics: Photocleavable Proteins on 2017-07-22 18:52:17