| Title | Bacteria Development Marks New Era in Cellular Design | |
| Date | Monday December 11 2017, @11:36PM | |
| Author | takyon | |
| Topic | ||
| from the series-of-scaffolds dept. | ||
Bacteria breakthrough marks new era in cellular design and biofuel production
Scientists at the universities of Kent and Bristol have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production.
Because there is a growing need for agricultural or renewable production of biofuels and other commodity chemicals to move away from fossil fuels, scientists have long sought to enhance the internal organisation of bacteria and improve the efficiency of the cells for making nutrients, pharmaceuticals and chemicals.
The research team, led by Professor Martin Warren at Kent's School of Biosciences, working with professors Dek Woolfson and Paul Verkade at Bristol, found they could make nano-tubes that generated a scaffold inside bacteria.
With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.
The researchers designed protein molecules and developed techniques to allow E. coli to make long tubes that contain a coupling device to which other specific components can be attached. A production line of enzymes could then be arranged along the tubes, generating efficient internal factories for the coordinated production of important chemicals.
Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm (DOI: 10.1038/nchembio.2535) (DX)
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