| Title | Tbx6 Revealed As Crucial To Heart And Skeleton Formation From Stem Cells | |
| Date | Wednesday August 15 2018, @05:05AM | |
| Author | Fnord666 | |
| Topic | ||
| from the his-heart-grew-three-sizes-that-day dept. | ||
Many studies have attempted to identify a single transcription factor that can induce formation of the mesoderm, an early layer in embryonic development, without help from other cellular proteins. None have been successful, until now.
In a new study published in Cell Stem Cell, titled "Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification," a research team, including experts from the University of Tsukuba, screened over 50 transcription factors and found that Tbx6 alone was able to stimulate mesoderm formation in laboratory-grown stem cells, and could cause those stem cells to become cardiovascular or musculoskeletal cells.
[...] In the study, temporary production of Tbx6 caused the formation of mesoderm that later produced cardiovascular cells, while continuous Tbx6 expression suppressed this cardiovascular-forming mesoderm and caused formation of mesoderm that later produced musculoskeletal cells.
"Our analyses revealed a connection between early Tbx6 expression and cardiovascular lineage differentiation, and we believe that our study and similar studies may change the current view of lineage specification during development," Dr. Ieda explains. "Importantly, this essential and unappreciated function of Tbx6 in mesoderm and cardiovascular specification is conserved from lower organisms to mammals, so this discovery may have wide-ranging applicability in regenerative medicine."
Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification (DOI: 10.1016/j.stem.2018.07.001) (DX)
| Links |
printed from SoylentNews, Tbx6 Revealed As Crucial To Heart And Skeleton Formation From Stem Cells on 2024-04-24 12:04:09