| Title | Activating Tooth Regeneration In Mice | |
| Date | Saturday February 23 2019, @04:15AM | |
| Author | CoolHand | |
| Topic | ||
| from the dentist-replacement dept. | ||
Most reptiles and fish have multiple sets of teeth during their lifetime. However, most mammals, such as humans, have only one set of replacement teeth and some mammals, like mice, have only a single set with no replacement. This diversity raises both evolutionary questions -- how did different tooth replacement strategies evolve? -- and developmental ones -- which mechanisms prevent replacement teeth in animals that lost them?
In a new paper in Development, Professor Abigail Tucker and PhD student Elena Popa of King's College London tackle these questions with a molecular analysis of mouse tooth development. They have pinpointed why mice don't have replacement teeth by comparing gene expression in the dental lamina, the area that forms the teeth, of the mouse and the minipig, which has two sets of teeth.
[...]Using sophisticated genetic techniques, the researchers activated Wnt signalling in the mouse RSDL at E15.5 and E16 stages of development, revitalising this structure, and additional teeth were formed as a consequence.
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printed from SoylentNews, Activating Tooth Regeneration In Mice on 2024-04-20 12:25:44