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RandomFactor writes:

University of Sheffield and Rutherford Appleton Laboratory (RAL) scientists have discovered several new related (dinuclear RuII) compounds which visualize and kill gram-negative bacteria, such as E. coli (note - no word on whether it works on synthetic E.coli)

Bacteria are classified generally by what type of staining works on them using a method developed in the 1800's by Hans Christian Gram. 'Gram-negative' bacteria retain a stain color that shows them as a pinkish red coloring, these bacteria have cell walls that make it difficult to get drugs into them and many gram-negative bacteria have become significantly or even completely resistant to available drug treatments.

A new drug in the difficult gram-negative space is particularly important. Drug resistant bacteria already cause the deaths of over 50 thousand people a year in the US and EU alone, and as many as 10 million people a year could die worldwide every year by 2050 due to antibiotic resistant infections.

Doctors have not had a new treatment for gram-negative bacteria in the last 50 years, and no potential drugs have entered clinical trials since 2010.

The new drug compound has a range of exciting opportunities. As Professor Jim Thomas explains: "As the compound is luminescent it glows when exposed to light. This means the uptake and effect on bacteria can be followed by the advanced microscope techniques available at RAL.

"This breakthrough could lead to vital new treatments to life-threatening superbugs and the growing risk posed by antimicrobial resistance."

The studies at Sheffield and RAL have shown the compound seems to have several modes of action, making it more difficult for resistance to emerge in the bacteria.

Better yet

Mammalian cell culture and animal model studies indicate that the complex is not toxic to eukaryotes, even at concentrations that are several orders of magnitude higher than its minimum inhibitory concentration (MIC).

The researchers plan to test the compounds against additional multi drug resistant bacteria next.

Journal Reference: Kirsty L. Smitten et al, Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria, ACS Nano (2019). DOI: 10.1021/acsnano.8b08440, Supporting Information

Related Coverage

Original Submission

1. "RandomFactor" - https://soylentnews.org/~RandomFactor/
2. "visualize and kill gram-negative bacteria" - https://www.eurekalert.org/pub_releases/2019-05/uos-nc052219.php
3. "synthetic E.coli" - https://soylentnews.org/article.pl?sid=19/05/28/0355209
4. "DOI: 10.1021/acsnano.8b08440" - http://dx.doi.org/10.1021/acsnano.8b08440
5. "Supporting Information" - https://pubs.acs.org/doi/suppl/10.1021/acsnano.8b08440/suppl_file/nn8b08440_si_001.pdf
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46. "WHO Warns of Increasing Antibiotic Resistance" - https://soylentnews.org/article.pl?sid=14/04/30/2126237
47. "Original Submission" - https://soylentnews.org/submit.pl?op=viewsub&subid=34060

printed from SoylentNews, New Compounds Found Which Illuminate and Kill Drug Resistant Gram Negative Bacteria on 2023-06-02 02:57:32