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Title    A Non-Destructive Method of Analysing Molecules in Cells
Date    Tuesday June 02 2020, @11:51PM
Author    martyb
from the bright-idea dept.

Arthur T Knackerbracket has found the following story:

When investigating how tumors grow, or how pharmaceuticals affect different types of cells, researchers have to understand how molecules within a cell react—and interact. This is possible with modern laser microscopy. Until now, however, molecules in cell specimens had to be labelled with fluorescent substances in order to make them visible, and this can distort the very behavior of the molecules. Research groups from Bielefeld University and the University of Hong Kong have developed a laser microscope that works without having to label the molecules. For this, the researchers innovated a unique compact fibre laser instead of the solid-state lasers that had previously been used. The new microscope generates far less noise when in use than customary designs, making it suitable for use in operating rooms. The researchers presented their innovative technology in the journal Light: Science and Applications, which is published by Springer Nature.

"Label-free microscopic imaging is currently a hot topic in biomedical research," says Professor Dr. Thomas Huser, a biophysicist who leads the Biomolecular Photonics research group at Bielefeld University. His team worked together with Professor Dr. Kenneth K.Y. Wong's research group at the University of Hong Kong on the fibre laser microscope.

"Staining with fluorescent markers is generally unsuitable for in-vivo tissues," says Huser. "Label-free microscopy is needed, for instance, to investigate how various new types of cells develop from stem cells. It also allows for a tumor to be demarcated from normal tissue without staining. And we can ascertain how pharmaceutical compounds react with molecules in the muscle tissue cells of the heart and liver, as well as other cells."

Journal Reference:
Cihang Kong, Christian Pilger, Henning Hachmeister, et al. High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser [open], Light: Science & Applications (DOI: 10.1038/s41377-020-0259-2)

Original Submission


  1. "following story" -
  2. "10.1038/s41377-020-0259-2" -
  3. "Original Submission" -

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