| Title | Breakthrough Study Finds Age-Related Cognitive Decline May be Reversible | |
| Date | Friday January 22 2021, @03:00AM | |
| Author | requerdanos | |
| Topic | ||
| from the more-lucky-research-mice dept. | ||
Breakthrough study finds age-related cognitive decline may be reversible:
A breakthrough study from a team of neurologists at Stanford University claims to have discovered one way immune cells become dysfunctional as we age, leading to the inflammatory hyperdrive that plays a role in most age-related disease from cancer to cognitive decline. Preliminary study suggests this immune dysfunction can be reversed, pointing to compelling future anti-aging therapies.
[...] The specific focus of the new study, published in the journal Nature, was a hormone called prostaglandin E2 (PGE2). Levels of this particular hormone have previously been found to rise with aging. PGE2 is also known to promote inflammatory activity in immune cells.
[...] Katrin Andreasson, senior author on the new study, calls this age-induced inflammatory mechanism, "a double-whammy – a positive feedback loop."
[...] "Our study suggests that cognitive aging is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restore youthful immune functions," the researchers conclude in the new study.
Also at: Stanford.edu
Journal Reference:
Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, et al. Restoring metabolism of myeloid cells reverses cognitive decline in ageing, Nature (DOI: 10.1038/s41586-020-03160-0)
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