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Title    Unorthodox "Exercise in a Pill" Could Offer Simple Solution for At-Risk Patients
Date    Thursday December 02 2021, @06:29AM
Author    martyb
from the eye-see-watt-you-did-there dept.

upstart writes:

“Exercise in a pill” could offer solution for at-risk people:

Researchers from The Australian National University (ANU) have identified unique molecular signals in the body that could hold the key to developing a supplement capable of administering the health benefits of exercise to patients incapable of physical activity.

The molecular messages are sent to our brain and potentially our eyes immediately after we exercise.

The ANU team is conducting research to better understand what impact these molecular messages have on retinal health, but also the central nervous system and eye diseases such as age-related macular degeneration (AMD).

Associate Professor Riccardo Natoli, Head of Clear Vision Research at ANU, says the molecules could potentially be hijacked, recoded and "bottled up" in a pill and taken like a vitamin.

"The beneficial messages being sent to the central nervous system during exercise are packaged up in what are known as lipid particles. We are essentially prescribing the molecular message of exercise to those who physically aren't able to," he said.

"We think that as you age, the ability to communicate between the muscles and the retina starts to be lost. Similar to taking supplements, maybe we can provide genetic or molecular supplementation that enables that natural biological process to continue as we age.

"Our goal is to figure out what these molecules are communicating to the body and how they're communicating."

Journal Reference:
Joshua A. Chu-Tan, Max Kirkby, Riccardo Natoli. Running to save sight: The effects of exercise on retinal health and function, Clinical & Experimental Ophthalmology (DOI: 10.1111/ceo.14023)

Original Submission


  1. "upstart" -
  2. "“Exercise in a pill” could offer solution for at-risk people" -
  3. "10.1111/ceo.14023" -
  4. "Original Submission" -

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