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New Tool for Optogenetics: Photocleavable Proteins

Accepted submission by takyon at 2017-03-16 08:26:29
Science

Researchers have created a protein that breaks into two pieces when exposed to light [ualberta.ca]:

Researchers at the University of Alberta have developed a new method of controlling biology at the cellular level using light. The tool -- called a photocleavable protein -- breaks into two pieces when exposed to light, allowing scientists to study and manipulate activity inside cells in new and different ways.

First, scientists use the photocleavable protein to link cellular proteins to inhibitors, preventing the cellular proteins from performing their usual function. This process is known as caging. "By shining light into the cell, we can cause the photocleavable protein to break, removing the inhibitor and uncaging the protein within the cell," said lead author Robert Campbell [ualberta.ca], professor in the Department of Chemistry [ualberta.ca]. Once the protein is uncaged, it can start to perform its normal function inside the cell. The tool is relatively easy to use and widely applicable for other research that involves controlling processes inside a cell.

Optogenetic control with a photocleavable protein, PhoCl [nature.com] (DOI: 10.1038/nmeth.4222) (DX [doi.org])

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