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3-in-1 vaccine against traveler's diarrhea [sciencedaily.com]

Science News from research organizations 3-in-1 vaccine against traveler's diarrhea Date: October 10, 2018 Source: University of Guelph Summary: A professor has discovered a novel approach to developing a first-ever vaccine for three common pathogens that cause traveler's diarrhea and kill more than 100,000 children living in developing countries each year. The vaccine yokes together proteins from pathogenic E.coli with sugars from Shigella and Camplyobacter jejuni -- three bugs that are major causes of bacterial diarrhea globally. Currently no licensed vaccines exist against any of these pathogens. Share: FULL STORY

A first-ever vaccine designed to deliver a one-two-three punch against the main causes of traveller's diarrhea worldwide may result from new research published by a University of Guelph chemist.

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Prof. Mario Monteiro says his novel three-in-one approach to developing a new vaccine could also save lives in developing countries, where it's estimated that these three common pathogens kill more than 100,000 children under age five each year.

His research was recently published in the journal Vaccine.

The paper discusses Monteiro's so-called conjugate vaccine that yokes together proteins from pathogenic E. coli with sugars from Shigella and Campylobacter jejuni. All three bugs are major causes of bacterial diarrhea globally.

In tests with mice, the vaccine provided immunity against all three pathogens.

No licensed vaccines exist against any of these pathogens. A sugar-based vaccine developed by Monteiro in 2009 against campylobacter alone is currently undergoing human trials but is still an estimated decade away from potential release.

He said this new three-in-one approach may ultimately overtake that earlier single-target vaccine, although any new vaccine may take decades to test and release. "We're targeting three pathogens at the same time," he said. "Instead of three shots, maybe you only need one."

As with the earlier campylobacter vaccine, this new method has been patented by U of G and the United States Naval Medical Research Center, which funded the research.

Monteiro said further research is needed to determine the optimum amounts of protein and sugars in the vaccine and to make the vaccine more efficient.

He worked on the project with former post-doc Zuchao Ma and former graduate students Brittany Pequegnat and Eman Omari, along with U.S. navy researchers.

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Story Source:

Materials [uoguelph.ca] provided by University of Guelph [uoguelph.ca]. Note: Content may be edited for style and length.

Journal Reference:

1. Renee M. Laird, Zuchao Ma, Nelum Dorabawila, Brittany Pequegnat, Eman Omari, Yang Liu, Alexander C. Maue, Steven T. Poole, Milton Maciel, Kavyashree Satish, Christina L. Gariepy, Nina M. Schumack, Annette L. McVeigh, Frédéric Poly, Cheryl P. Ewing, Michael G. Prouty, Mario A. Monteiro, Stephen J. Savarino, Patricia Guerry. Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella. Vaccine, 2018; DOI: 10.1016/j.vaccine.2018.09.052 [doi.org]

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University of Guelph. "3-in-1 vaccine against traveler's diarrhea." ScienceDaily. ScienceDaily, 10 October 2018. <www.sciencedaily.com/releases/2018/10/181010132346.htm>. University of Guelph. (2018, October 10). 3-in-1 vaccine against traveler's diarrhea. ScienceDaily. Retrieved October 11, 2018 from www.sciencedaily.com/releases/2018/10/181010132346.htm University of Guelph. "3-in-1 vaccine against traveler's diarrhea." ScienceDaily. www.sciencedaily.com/releases/2018/10/181010132346.htm (accessed October 11, 2018). advertisement

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