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Herbicide Linked to Human Liver Disease

Accepted submission by chromas at 2019-05-14 23:49:00
Science
It’s in the Weeds: Herbicide Linked to Human Liver Disease [technology.org]

In a study published in Clinical Gastroenterology and Hepatology [sciencedirect.com][$], a team [...] examined glyphosate excretion in the urine samples of two patient groups — those with a diagnosis of NASH (nonalcoholic steatohepatitis, a type of nonalcoholic fatty liver disease or NAFLD), and those without. The results, they found, were significant: Regardless of age, race, body mass index (BMI), ethnicity or diabetes status, glyphosate residue was significantly higher in patients with NASH than it was in patients with a healthier liver.

The findings, coupled with prior animal studies, said Mills, suggest a link between the use of commercial glyphosate in our food supply, which has increased significantly over the past 25 years, and the prevalence of NAFLD in the United States, which too has been on the rise for two decades.

“There have been a handful of studies, all of which we cited in our paper, where animals either were or weren’t fed Roundup or glyphosate directly, and they all point to the same thing: the development of liver pathology,” said Mills. “So I naturally thought: ‘Well, could it be exposure to this same herbicide that is driving liver disease in the U.S.?’”

The study examined urine samples of 93 patients. Forty-one percent were male; 42 percent were white or Caucasian; 35 percent were Hispanic or Latino. Average BMI was 31.8. Patients were originally recruited as part of a larger study at the UC San Diego NAFLD Research Center conducted between 2012 and 2018. Liver biopsies were used to determine the presence or absence of NAFLD while classifying the subjects by cohort.


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