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The Korea Institute of Science and Technology (KIST) said its researchers have discovered a new protein binding that repairs brain damage.
The research team, led by Doctor Hwang Eun-mi from Brain Science Institute (BSI) at KIST and Professor Suk Kyoung-ho of Kyungpook National University College of Medicine, found that new protein binding of Hevin and Calcyon is needed in the repairing process of brain damage.
The protein binding plays a key role in the early stage of recovery, it said.
Researchers experimented with animal models having brain damage, using combined protein to observe a staged process of brain recovery. If the subjects lack in the Hevin-Calcyon binding, their recovery process could be delayed, the team found.
The enzyme proteins induced by inflammatory reactions in the early stage of brain damage decompose Hevin, inhibiting Hevin-Calcyon binding. In the animal experiment, researchers confirmed that the recovery started in two to three weeks instead of four weeks by administering inflammatory response inhibitors directly to the brain's damaged areas.
“The inflammatory response occurs in both general and degenerative brain disease, and we found physicians should consider the Hevin-Calcyon binding,” Dr. Hwang said. “The study results could lead to the development of treatments for incurable brain diseases related to synaptic information disorders.”
The study results were published in the latest issue of Cell Death & Differentiation.