| Title | 3-D Human 'Mini-Brains' Shed New Light on Genetic Underpinnings of Major Mental Illness | |
| Date | Saturday April 21 2018, @10:22AM | |
| Author | mrpg | |
| Topic | ||
| from the lego-brains dept. | ||
Major mental illnesses such as schizophrenia, severe depression and bipolar disorder share a common genetic link. Studies of specific families with a history of these types of illnesses have revealed that affected family members share a mutation in the gene DISC1. While researchers have been able to study how DISC1 mutations alter the brain during development in animal models, it has been difficult to find the right tools to study changes in humans. However, advancements in engineering human stem cells are now allowing researchers to grow mini-organs in labs, and gene-editing tools can be used to insert specific mutations into these cells.
Researchers from Brigham and Women's Hospital are leveraging these new technologies to study the effects of DISC1 mutations in cerebral organoids -- "mini brains" -- cultured from human stem cells. Their results are published in Translational Psychiatry.
"Mini-brains can help us model brain development," said senior author Tracy Young-Pearse, PhD, head of the Young-Pearse Lab in the Ann Romney Center for Neurologic Diseases at BWH. "Compared to traditional methods that have allowed us to investigate human cells in culture in two-dimensions, these cultures let us investigate the three-dimensional structure and function of the cells as they are developing, giving us more information than we would get with a traditional cell culture."
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printed from SoylentNews, 3-D Human 'Mini-Brains' Shed New Light on Genetic Underpinnings of Major Mental Illness on 2024-05-16 13:11:03