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takyon writes:

Study: Suicidal Thoughts Rapidly Reduced with Ketamine

Ketamine was significantly more effective than a commonly used sedative in reducing suicidal thoughts in depressed patients, according to researchers at Columbia University Medical Center (CUMC). They also found that ketamine's anti-suicidal effects occurred within hours after its administration.

The findings were published online last week in the American Journal of Psychiatry.

Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial (DOI: 10.1176/appi.ajp.2017.17060647) (DX)

The reduction in SSI score at day 1 was 4.96 points greater for the ketamine group compared with the midazolam group (95% CI=2.33, 7.59; Cohen's d=0.75). The proportion of responders (defined as having a reduction ≥50% in SSI score) at day 1 was 55% for the ketamine group and 30% for the midazolam group (odds ratio=2.85, 95% CI=1.14, 7.15; number needed to treat=4.0). Improvement in the Profile of Mood States depression subscale was greater at day 1 for the ketamine group compared with the midazolam group (estimate=7.65, 95% CI=1.36, 13.94), and this effect mediated 33.6% of ketamine's effect on SSI score. Side effects were short-lived, and clinical improvement was maintained for up to 6 weeks with additional optimized standard pharmacotherapy in an uncontrolled follow-up.

Wikipedia's entry on midazolam notes:

Midazolam, marketed under the trade name Versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. It works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories. It is also useful for the treatment of seizures

Related: 4/20: The Third Time's Not the Charm
Study Suggests Psilocybin "Resets" the Brains of Depressed People

Original Submission

1. "takyon" - https://soylentnews.org/~takyon/
2. "Study: Suicidal Thoughts Rapidly Reduced with Ketamine" - https://www.sciencedaily.com/releases/2017/12/171214164014.htm
3. "Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial" - https://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2017.17060647
4. "DX" - https://doi.org/10.1176/appi.ajp.2017.17060647
5. "midazolam" - https://en.wikipedia.org/wiki/Midazolam
6. "4/20: The Third Time's Not the Charm" - https://soylentnews.org/article.pl?sid=17/04/06/1914231
7. "Study Suggests Psilocybin "Resets" the Brains of Depressed People" - https://soylentnews.org/article.pl?sid=17/10/14/1238206
8. "Original Submission" - https://soylentnews.org/submit.pl?op=viewsub&subid=23837

printed from SoylentNews, Ketamine Reduces Suicidal Thoughts in Depressed Patients on 2024-05-04 16:08:22