from the hempire-strikes-back dept.
Since this time last year, Ohio, Florida, North Dakota, and Arkansas legalized medical cannabis, Illinois decriminalized it, and California, Nevada, Maine and Massachusetts legalized recreational cannabis. An attempt to legalize recreational cannabis in Arizona narrowly failed.
29 U.S. states and the District of Columbia have legalized cannabis for medical use, although restrictions vary widely from state to state.
Germany's medical cannabis law was approved in January and came into effect in March. Poland has also legalized medical cannabis, and Georgia's Supreme Court has ruled that imprisonment for possession of small amounts of cannabis is unconstitutional.
🍁 Cannada: Not So Fast 🍁
Last week, Canadian Prime Minister Justin Trudeau unveiled (archive) legislation (archive) that would make Canada the first major Western country to legalize recreational cannabis (the only country to legalize it to date is Uruguay, although implementation has taken years), dealing a serious blow to the crumbling United Nations Single Convention on Narcotic Drugs. However, the Liberal Party of Canada intends to wait more than a year to act on its campaign promise, during which time Canadians can still face prosecution for possession of the drug:
True to form, this government has written down a series of talking points, in this case, trying to make it sound like it's cracking down on pot rather than legalizing it. And Justin Trudeau's ministers are sticking to the messaging from party central like a child reciting Dr. Seuss.
Not once in that As It Happens interview did [Justice Minister Jody] Wilson-Raybould explain why the government intends to keep on criminalizing Canadians so unfairly (see the Liberal party's website statement) for another year. Instead, literally every second time she opened her mouth, she re-spouted the line about "strictly regulating and restricting access." Off asked eight questions. Four times, Wilson-Raybould robotically reverted to the same phrase.
Meanwhile, Public Safety Minister Ralph Goodale, a parliamentary lifer who mastered the art of repetitive dronetalk sometime back in the last millennium, was out peddling more or less the same line, but with an added warning: Not only will the government continue to criminalize Canadians for what it considers a trifling offence, enforcement will be vigorous. "Existing laws prohibiting possession and use of cannabis remain in place, and they need to be respected," Goodale declared. "This must be an orderly transition. It is not a free-for-all." Why the government cannot simply decide to invoke prosecutorial and police discretion, and cease enforcing the cannabis laws it considers unjust, was not explained. Why that would necessarily be a "free for all" also went unexplained.
The Liberal Party of Canada has taken pains to remind everyone that the Conservative Party will "do everything they can to stop real change and protect a failed status quo". Unfortunately, they did not get the memo that "marijuana" is a term with racist origins.
Make like a tree and legalize it, Cannadia... Cannibinoidia.
President Trump and Attorney General Jeff Sessions
Backtrack to April 20th, 2016. Bernie Sanders still seemingly had a shot at becoming the President of the United States. Sanders, as well as Hillary Clinton (though begrudgingly), supported decriminalization of cannabis, medical use, and the continuation of states making decisions about recreational use. The #2 Republican candidate Ted Cruz also had a "let the states sort it out" stance.
One contender stood out, and he went on to become the @POTUS to #MAGA. The widely predicted "third term" was prevented, and that outcome may greatly affect a burgeoning semi-legal cannabis industry. One recent casualty are Amsterdam-style "cannabis clubs" (think: brewpubs). Colorado's legislature has backed off on a bill that would have allowed on-site consumption of cannabis at dispensaries due to the uncertain future of federal enforcement of cannabis prohibition.
Trump's position on cannabis has been ill-defined, although he supports medical use and has indicated that states should handle the issue. But the same can't be said of his Attorney General, former Senator Jeff Sessions. Here are some quotes about the drug from Mr. Sessions:
We need grown-ups in charge in Washington to say marijuana is not the kind of thing that ought to be legalized, it ought not to be minimized, that it's in fact a very real danger.
I think one of [President Obama's] great failures, it's obvious to me, is his lax treatment in comments on marijuana... It reverses 20 years almost of hostility to drugs that began really when Nancy Reagan started 'Just Say No.
You can't have the President of the United States of America talking about marijuana like it is no different than taking a drink... It is different... It is already causing a disturbance in the states that have made it legal.
Good people don't smoke marijuana.
Cannabis advocates are becoming increasingly paranoid about the federal government's stance towards the states (and a certain District) that have legalized cannabis. And this is following an Obama administration that was criticized for conducting raids in states with legalization. It is too early to tell how the Trump administration will choose to deal with cannabis, but there are signs that harsher policies and greater enforcement could be coming:
On Wednesday, [April 5th,] Jeff Sessions directed Justice Department lawyers to evaluate marijuana enforcement policy and send him recommendations. And some state officials are worried. This week the governors of Alaska, Colorado, Oregon and Washington wrote the attorney general. They asked Sessions and the new Treasury secretary to consult with them before making any changes to regulations or enforcement.
At the White House, press secretary Sean Spicer said recently that the president is sympathetic to people who use marijuana for medical reasons. He pointed out that Congress has acted to bar the Justice Department from using federal money to interfere in state medical cannabis programs. But Spicer took a harsh view of recreational marijuana. "When you see something like the opioid addiction crisis blossoming in so many states around this country, the last thing we need to be doing is encouraging people. There is still a federal law we need to abide by," Spicer said.
Really, Spicer? Recreational cannabis use shouldn't be encouraged during an opioid addiction crisis? Read on.
Politics nexus unavailable for comment.
The Opioid Crisis Drags On (it's relevant)
Heroin use has become more dangerous as dealers have increasingly added other substances that massively increase potency without affecting the size of a dose significantly. Carfentanil, which is used as an elephant tranquilizer, has led to hundreds of deaths over very short timespans. It is impossible for the average user to predict the potency and potential danger of street heroin. While there have been international responses to these compounds, new chemical analogues are being created all the time:
Chinese labs producing the synthetic opiates play hide-and-seek with authorities. On their websites, they list fake addresses in derelict shopping centers or shuttered factories, and use third-party sales agents to conduct transactions that are hard to trace. The drugs themselves are easy to find with a Google search and to buy with a few mouse clicks. A recent check found more than a dozen Chinese sites advertising fentanyl, carfentanil, and other derivatives, often labeled as "research chemicals," for sale through direct mail shipments to the United States. On one website, carfentanil goes for $361 for 50 grams: tens of thousands of lethal doses.
The cat-and-mouse game extends to chemistry, as the makers tinker with fentanyl itself. Minor modifications like adding an oxygen atom or shifting a methyl group can be enough to create whole new entities that are no longer on the list of sanctioned compounds. Carfentanil itself was, until recently, unregulated in China.
2016 saw the addition of kratom to Schedule I of the Controlled Substances Act in the U.S. Advocates for the tree leaf drug, which was formerly classified as a supplement, believe that its painkiller effects and low risk factors make it a useful replacement for the oft-deadly opioids that millions of Americans are addicted to. Kratom users have treated their pain and opioid withdrawal symptoms using the formerly "legal high". The DEA has refused to acknowledge this application and points out the "skyrocketing" number of calls to the Poison Control Center regarding kratom in recent years. One skeptic of kratom, Dr. Josh Bloom of the American Council on Science and Health, has looked at the same evidence and concluded that the trail of bodies left by substances like fentanyl and the scarce number of deaths (perhaps wrongly) attributed to kratom make it clear that the substance is the better "poison". He also notes that:
The number of calls to poison control centers is not reliable for determining how many poisonings actually occurred. It is a crude approximation at best.
Much like kratom, medical cannabis has been touted as a solution to the opioid crisis. States with legalized medical cannabis have seen a reduction in reported instances of opioid dependence [DOI: 10.1016/j.drugalcdep.2017.01.006] [DX] So it is puzzling that White House Press Secretary Sean Spicer would use opioids as a bludgeon against cannabis legalization while AG Sessions expresses astonishment over the suggestion of using cannabis as a "cure" for the opioid crisis.
Bonus: Here's a video (2m14s) of a woman getting administered Narcan/naloxone. Here's an alternate video (2m39s) in which a man who overdosed on heroin is able to sit up in about a minute after being administered naloxone.
⚚ The Slow March for Science ⚕
While the Drug Enforcement Agency has refused to reclassify cannabis from its current Schedule I status, citing the supposedly rigorous conclusions reached by the Food and Drug Administration, it will allow more than one institution to grow cannabis for research purposes, ending the monopoly held by the University of Mississippi. However, the Schedule I status of cannabis remains an impediment to further research:
[...] DEA's decision not to reschedule marijuana presents a Catch-22. By ruling that there is not enough evidence of "currently accepted medical use"—a key distinction between the highly restrictive Schedule I classification and the less restrictive Schedule II—the administration essentially makes it harder to gather such evidence.
"They're setting a standard that can't be met," says David Bradford, a health economist at the University of Georgia, Athens. "That level of proof is never going to be forthcoming in the current environment because it requires doing a really extensive clinical trial series, and given that a pharmaceutical company can't patent whole plant marijuana, it's in no company's interest to do that."
Schedule I status presents obstacles for clinical researchers because of restrictions on how the drugs must be stored and handled, Bradford says. Perhaps more significant, that listing may evoke skittishness at funding agencies and on the institutional review boards that must sign off on research involving human subjects.
"It doesn't resemble cannabis. It doesn't smell like cannabis," Sisley told PBS NewsHour last week.
Jake Browne, a cannabis critic for the Denver Post's Cannabist marijuana news site, agrees. "That is, flat out, not a usable form of cannabis," he said. Browne should know: He's reviewed dozens of strains professionally and is running a sophisticated marijuana growing competition called the Grow-Off.
"In two decades of smoking weed, I've never seen anything that looks like that," Browne said. "People typically smoke the flower of the plant, but here you can clearly see stems and leaves in there as well, parts that should be discarded. Inhaling that would be like eating an apple, including the seeds inside it and the branch it grew on."
Research on cannabinoids and psychedelics is proceeding, slowly. One study published yesterday (74 years after the first LSD trip) came to an astounding conclusion: Psychedelics can induce a "heightened state of consciousness":
Healthy volunteers who received LSD, ketamine or psilocybin, a compound found in magic mushrooms, were found to have more random brain activity than normal while under the influence, according to a study into the effects of the drugs. The shift in brain activity accompanied a host of peculiar sensations that the participants said ranged from floating and finding inner peace, to distortions in time and a conviction that the self was disintegrating.
[...] What we find is that under each of these psychedelic compounds, this specific measure of global conscious level goes up, so it moves in the other direction. The neural activity becomes more unpredictable," said Anil Seth, a professor of neuroscience at the University of Sussex. "Until now, we've only ever seen decreases compared to the baseline of the normal waking state."
Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin (open, DOI: 10.1038/srep46421) (DX)
♯ Ending on High Notes ♯
And now to scrape the bottom of the barrel:
- Americans Don't Care If Their Parents Know They Smoke Weed, Survey Says
- California Today: At Newspapers, Covering Pot Like Wine (archive)
- Nation's first public needle vending machine for drug users debuts in Las Vegas
- GRiZ Won the Celebrity Weed Game Without Selling Out
- Secret A.T.F. Account Paid for $21,000 Nascar Suite and Las Vegas Trip (archive)
- Legal Marijuana Ends at Airport Security, Even if It's Rarely Stopped (archive)
- Anti-Heroin Video From a Florida Sheriff Appalls Critics but Impresses Constituents (archive)
April 20th (420) is a celebration of stoner/cannabis culture. In recent years, decriminalization and legalization of marijuana has accelerated as public opinion has shifted, so there are more reasons to celebrate...
It's that time of the year again. Time to talk about drugs and the war on them because some stoners declared a holiday or something.
At the time, I was writing a book about the politics of drug prohibition. I started to ask Ehrlichman a series of earnest, wonky questions that he impatiently waved away. "You want to know what this was really all about?" he asked with the bluntness of a man who, after public disgrace and a stretch in federal prison, had little left to protect. "The Nixon campaign in 1968, and the Nixon White House after that, had two enemies: the antiwar left and black people. You understand what I'm saying? We knew we couldn't make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news. Did we know we were lying about the drugs? Of course we did."
[Oh yes, it continues...]
The Obama administration has denied a bid by two Democratic governors to reconsider how it treats marijuana under federal drug control laws, keeping the drug for now, at least, in the most restrictive category for U.S. law enforcement purposes. Drug Enforcement Administration chief Chuck Rosenberg says the decision is rooted in science. Rosenberg gave "enormous weight" to conclusions by the Food and Drug Administration that marijuana has "no currently accepted medical use in treatment in the United States," and by some measures, it remains highly vulnerable to abuse as the most commonly used illicit drug across the nation.
"This decision isn't based on danger. This decision is based on whether marijuana, as determined by the FDA, is a safe and effective medicine," he said, "and it's not." Marijuana is considered a Schedule I drug under the Controlled Substances Act, alongside heroin and LSD, while other, highly addictive substances including oxycodone and methamphetamine are regulated differently under Schedule II of the law. But marijuana's designation has nothing to do with danger, Rosenberg said.
The Post article notes:
In the words of a 2015 Brookings Institution report, a move to Schedule II "would signal to the medical community that [the Food and Drug Administration and the National Institutes of Health] are ready to take medical marijuana research seriously, and help overcome a government-sponsored chilling effect on research that manifests in direct and indirect ways."
However, the DEA will expand the number of locations federally licensed to grow cannabis for research from the current total of... 1: the University of Mississippi.
Kratom, an herbal drug made of ground-up tree leaves, is "temporarily" joining other natural substances such as cannabis, psilocybin, and peyote on the schedule I list of the Controlled Substances Act. The active ingredients in kratom, the indole alkaloids mitragynine and 7-hydroxymitragynine, are both being added to the list for up to three years, after which they can be added permanently.
Prior to this move, the U.S. has already been seizing shipments of kratom:
In 2014, the FDA issued an import alert that allowed US Customs agents to detain kratom without a physical examination. "We have identified kratom as a botanical substance that could pose a risk to public health and have the potential for abuse," said Melinda Plaisier, the FDA's associate commissioner for regulatory affairs. According to the DEA, between February 2014 and July 2016, nearly 247,000 pounds of kratom were seized.
Advocates say that kratom is a natural treatment for opioid addiction, an application that the Drug Enforcement Agency dismisses. Meanwhile, the heroin/opioid epidemic continues with "unprecedented" events like the recent 174 heroin overdoses in just six days in Cincinnati, Ohio.
Check out the implosion of this kratom subreddit, which is attempting to get 100,000 signatures on the White House petition site:
APATHY WILL GET US NOWHERE. IF THERE WAS EVER A TIME FOR US TO BAND TOGETHER, ITS NOW. stand with me brothers and sisters. hope is not lost.
When customers want a longer-lasting high, heroin dealers respond by augmenting their products with drugs like carfentanil:
A powerful drug that's normally used to tranquilize elephants is being blamed for a record spike in drug overdoses in the Midwest. Officials in Ohio have declared a public health emergency, and the U.S. Drug Enforcement Administration says communities everywhere should be on alert for carfentanil. The synthetic opioid is 100 times more potent than fentanyl, the prescription painkiller that led to the death earlier this year of the pop star Prince. Fentanyl itself can be up to 50 times more deadly than heroin.
In the past few years, traffickers in illegal drugs increasingly have substituted fentanyl for heroin and other opioids. Now carfentanil [alt link] is being sold on American streets, either mixed with heroin or pressed into pills that look like prescription drugs. Many users don't realize that they're buying carfentanil. And that has deadly consequences.
"Instead of having four or five overdoses in a day, you're having these 20, 30, 40, maybe even 50 overdoses in a day," says Tom Synan, who directs the Hamilton County Heroin Coalition Task Force in Southwest Ohio. He's also the police chief in Newtown, Ohio. Synan says carfentanil turned up in Cincinnati in July. At times, the number of overdoses has overwhelmed first responders. "Their efforts are truly heroic, to be going from call to call to call," he says. "One district alone had seen 14 in one shift, so they were nonstop."
First responders and emergency room workers are being told to wear protective gloves and masks. That's because carfentanil is so potent, it can be dangerous to someone who simply touches or inhales it. This was devastatingly clear back in 2002, after a hostage rescue operation in Moscow that went wrong. To overpower Chechen terrorists who'd seized control of a theater, Russian Special Forces sprayed a chemical aerosol into the building. More than 100 hostages were overcome and died. Laboratory tests by British investigators later revealed [open, DOI: 10.1093/jat/bks078] [DX] that the aerosol included carfentanil.
In the article about the DEA adding kratom to Schedule I, I mentioned an "unprecedented" amount of "heroin" overdoses in Cincinnati. The carfentanil-cut heroin boosted the overdose tally to 174 in 6 days (225 in Ohio, Indiana, Kentucky, and New Jersey):
Deaths have not spiked along with the overdose reports because police officers or emergency medical technicians are immediately administering naloxone, sometimes in more than one dose, to bring heroin users back to consciousness and start them breathing.
The Free Thought Project reports via AlterNet
There's one thing that appears to be saving more lives during the opioid epidemic than anything else--medical cannabis. While government touts meaningless attempts at addressing the problem--paying lip service to the people while protecting Big Pharma's profits and filling jails--people are saving themselves by turning to an ancient plant.
Yet another scientific study has confirmed that medical cannabis access reduces harm from opioid abuse among the population. A recent study published in the Drug and Alcohol Dependency journal found that states with legal medical cannabis experience fewer hospitalizations related to opioids.
"Medical marijuana legalization was associated with 23% and 13% reductions in hospitalizations related to opioid dependence or abuse and [opioid pain reliever] OPR overdose, respectively; lagged effects were observed after policy implementation."
Researchers from the University of California analyzed hospital administrative records for the period of 1997 to 2014. The author reported:
"This study demonstrated significant reductions on OPR- (opioid pain reliever) related hospitalizations associated with the implementation of medical marijuana policies. ... We found reductions in OPR-related hospitalizations immediately after the year of policy implementation as well as delayed reductions in the third post-policy year."
The data also show that cannabis-related hospitalizations did not increase after legalization, contrary to what prohibitionists would have you believe.
West Virginia MetroNews reported on April 5:
However, the bill includes some technical changes made after the House passed the bill earlier this week. Both chambers have agreed to those "clean ups", which do not affect the substance of the bill. The House is expected to sign off on those details and the bill then goes to Governor Jim Justice.
The bill will make West Virginia the 29th state [sic] allowing the use of marijuana for the treatment of certain kinds of pain and illnesses with approval by a physician. Under the legislation, the marijuana would have to be taken in pill or liquid form. It does not allow for marijuana to be smoked or gown[sic] by the patient.
Governor Justice has said he's not opposed to medical marijuana.
NORML, the National Organization for the Reform of Marijuana Laws now adds:
West Virginia legislators on Thursday [April 7] approved a significantly amended version of Senate Bill 386, which seeks to establish a state-regulated medical cannabis program. The measure now awaits action from Democrat Gov. Jim Justice, who has previously expressed support for permitting qualified patients access cannabis therapy.
If signed into law, West Virginia will become the 30th state to authorize by statute the physicians-recommended use of cannabis or cannabis-infused products.
Under the amended measure, qualified patients will be permitted to obtain cannabis-infused oils, pills, tinctures, or creams from a limited number of state-authorized dispensaries. Cannabis-based medications will be produced by state-licensed growers and processors. Patients will not be permitted to grow their own cannabis, nor will they be able to legally access or smoke herbal formulations of the plant. Similar restrictive programs are presently in place in Minnesota and New York and are awaiting implementation in Louisiana, Pennsylvania, and Ohio.
To participate in the proposed program, both patients and physicians would need to be registered with the state. Government officials are not mandated under the legislation to begin issuing patient identification cards until July 1, 2019.
We had two Soylentils submit stories about Attorney General Jeff Sessions:
Trump fires Attorney General Jeff Sessions
"US Attorney General Jeff Sessions has been fired by President Donald Trump.
[...] Mr Trump said Mr Sessions will be temporarily replaced by his chief of staff, Matthew Whitaker, who has criticised the Russia inquiry.
[...] In a resignation letter, Mr Sessions - a former Alabama senator who was an early supporter of Mr Trump - made clear the decision to go was not his own.
[...] The president cannot directly fire the special counsel, whose investigation Mr Trump has repeatedly decried as a witch hunt. But Mr Sessions' replacement will have the power to fire Mr Mueller or end the inquiry.
[...] Republican Senator Lindsey Graham said he looks forward to 'working with President Trump to find a confirmable, worthy successor so that we can start a new chapter at the Department of Justice'.
Mr Graham, of South Carolina, had said last year there would be 'holy hell to pay' if Mr Sessions was ever fired."
[...] House of Representatives Democratic leader Nancy Pelosi said: "It is impossible to read Attorney General Sessions' firing as anything other than another blatant attempt by President Trump to undermine & end Special Counsel Mueller's investigation."
Recreational cannabis is now legal in Canada... to a point. Here are some ground rules:
Adults of at least 18 years old will be allowed to carry and share up to 30 grams of legal marijuana in public, according to a bill that passed the Senate in June. They will also be allowed to cultivate up to four plants in their households and make products such as edibles for personal use.
[...] The supply of recreational marijuana could be limited, at least early on, in some stores. Officials in Nova Scotia and Manitoba said they won't have a large selection, at least not on the first day, CNN affiliate CBC News reported. [...] Marijuana will not be sold in the same location as alcohol or tobacco. Consumers are expected to purchase the drug from retailers regulated by provinces and territories or from federally licensed producers when those options are not available.
[...] Authorities will soon announce plans to pardon Canadians who have been convicted with possession of 30 grams or less of marijuana, CNN partner CTV reported. The production, distribution or sale of cannabis products will still be an offense for minors.
U.S. Senate Minority Leader Chuck Schumer (D-NY) has come out in support of federal cannabis decriminalization, just in time for 4/20:
The Minority Leader of the Senate is making it official the day before 4/20: He's down with legal weed. In an exclusive interview with VICE News, Sen. Chuck Schumer (D-NY) confirmed he is putting his name on legislation that he said is aimed at "decriminalizing" marijuana at the federal level. For Schumer, this is a shift. While he has backed medical marijuana and the rights of states to experiment with legal sales of pot, what he is proposing is a seismic shift in federal drug policy.
"Ultimately, it's the right thing to do. Freedom. If smoking marijuana doesn't hurt anybody else, why shouldn't we allow people to do it and not make it criminal?" Schumer said.
The legislation should be available within a week or so, and would remove cannabis (still listed as "Marihuana") from the Drug Enforcement Administration's list of Schedule I substances. States would then be free to regulate or continue to prohibit the plant. Cannabis advertising would be regulated as are alcohol and tobacco advertising. (Also at NPR, CNN, The Washington Post, and CNBC, as well as Reason taking a shot at Schumer for not doing it sooner.)
A majority of Americans support the legalization of cannabis, including, for the first time, a majority (51%) of Republicans, according to Gallup. Nine states and the District of Columbia have legalized cannabis for recreational use. 29 states, D.C., Guam, and Puerto Rico have legalized medical use of cannabis, and another 17 states have legalized the use of cannabidiol (CBD). Cannabis became available for recreational purposes in California on January 1.
Attorney General Jeff Sessions will roll back an Obama-era policy that gave states leeway to allow marijuana for recreational purposes.
Two sources with knowledge of the decision confirmed to The Hill that Sessions will rescind the so-called Cole memo, which ordered U.S. attorneys in states where marijuana has been legalized to deprioritize prosecution of marijuana-related cases.
The Associated Press first reported the decision.
Sessions, a vocal critic of marijuana legalization, has hinted for months that he would move to crack down on the growing cannabis market.
Republican Senator Cory Gardner says he will hold up the confirmation process for DoJ nominees:
Sen. Cory Gardner (R-Colo.) threatened on Thursday to start holding up the confirmation process for White House Justice Department nominees unless Attorney General Jeff Sessions reverses a decision to roll back a policy allowing legalized recreational use of marijuana in some states.
Gardner said in a series of tweets that Sessions had told him before he was confirmed by the Senate that he would not change an Obama-era policy that discouraged federal prosecutors from pursuing marijuana-related offenses in states where the substance had been legalized. Colorado is one of those states.
[...] The Justice Department's reversal of the Cole memo on Thursday came three days after California's new law allowing recreational marijuana use went into effect.
Previously: New Attorney General Claims Legal Weed Drives Violent Crime; Statistics be Damned
4/20: The Third Time's Not the Charm
Jeff Sessions Reboots the Drug War
According to Gallup, American Support for Cannabis Legalization is at an All-Time High
Opioid Commission Drops the Ball, Demonizes Cannabis
Recreational Cannabis Goes on Sale in California
Ketamine was significantly more effective than a commonly used sedative in reducing suicidal thoughts in depressed patients, according to researchers at Columbia University Medical Center (CUMC). They also found that ketamine's anti-suicidal effects occurred within hours after its administration.
The findings were published online last week in the American Journal of Psychiatry.
Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial (DOI: 10.1176/appi.ajp.2017.17060647) (DX)
The reduction in SSI score at day 1 was 4.96 points greater for the ketamine group compared with the midazolam group (95% CI=2.33, 7.59; Cohen's d=0.75). The proportion of responders (defined as having a reduction ≥50% in SSI score) at day 1 was 55% for the ketamine group and 30% for the midazolam group (odds ratio=2.85, 95% CI=1.14, 7.15; number needed to treat=4.0). Improvement in the Profile of Mood States depression subscale was greater at day 1 for the ketamine group compared with the midazolam group (estimate=7.65, 95% CI=1.36, 13.94), and this effect mediated 33.6% of ketamine's effect on SSI score. Side effects were short-lived, and clinical improvement was maintained for up to 6 weeks with additional optimized standard pharmacotherapy in an uncontrolled follow-up.
Wikipedia's entry on midazolam notes:
Midazolam, marketed under the trade name Versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. It works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories. It is also useful for the treatment of seizures
New Jersey Gov. Chris Christie, head of the presidential commission on opioids, warned of the dangers of marijuana in a letter to President Donald Trump earlier this month about the panel's findings, saying the current push for marijuana legalization could further fuel the opioid epidemic.
"There is a lack of sophisticated outcome data on dose, potency, and abuse potential for marijuana. This mirrors the lack of data in the 1990s and early 2000s when opioid prescribing multiplied across health care settings and led to the current epidemic of abuse, misuse and addiction," Christie wrote in the letter, which was released with the commission's final report.
"The Commission urges that the same mistake is not made with the uninformed rush to put another drug legally on the market in the midst of an overdose epidemic."
[...] But some experts say the commission's fixation on marijuana was bizarre and troubling, lending credence to outdated views of marijuana as a gateway drug. And these experts want to nip such thinking in the bud.
They emphasized that they support efforts to curb the nation's opioid epidemic, but not the demonization of marijuana in the process.
"I was surprised to see negative language about marijuana in the opioid report," said Dr. Chinazo Cunningham, a professor of medicine at the Albert Einstein College of Medicine. "Research that examines pain and marijuana shows that marijuana use significantly reduces pain. In addition, the majority of studies examining marijuana and opioids show that marijuana use is associated with less opioid use and less opioid-related deaths."
You had one job.
Study Finds That Legalized Medical Cannabis Led to a Decline in Medicare Prescriptions
New Attorney General Claims Legal Weed Drives Violent Crime; Statistics be Damned
4/20: The Third Time's Not the Charm
Jeff Sessions Reboots the Drug War
President Trump Declares the Opioid Crisis a National Emergency
According to Gallup, American Support for Cannabis Legalization is at an All-Time High
Opioid Crisis Official; Insys Therapeutics Billionaire Founder Charged; Walgreens Stocks Narcan
FDA Blocks More Imports of Kratom, Warns Against Use as a Treatment for Opioid Withdrawal
"The best way to prevent drug addiction and overdose is to prevent people from abusing drugs in the first place. If they don't start, they won't have a problem." – President Donald J. Trump
President Trump has declared the "Opioid Crisis" a nationwide public health emergency. This action will allow for "expanded access to telemedicine services" to remotely prescribe medicines for substance abuse, allow the Department of Health and Human Services to "more quickly make temporary appointments of specialists with the tools and talent needed to respond effectively to our Nation's ongoing public health emergency", allow the Department of Labor to issue dislocated worker grants for those "displaced from the workforce" due to the Opioid Crisis, and will help people with HIV/AIDS to receive substance abuse treatment. The press release lists several actions that the Trump Administration has taken to respond to the Opioid Crisis, including the July 2017 law enforcement action against AlphaBay.
The declaration has been criticized for not requesting any funds to respond to the Crisis. The "nationwide public health emergency" declaration is also distinct from a promised "national emergency declaration", which would have freed up money from the Disaster Relief Fund to be spent on the Crisis. 14 Senate Democrats have introduced a bill that would authorize $45 billion to address the Opioid Crisis. The Obama Administration called on Congress last year to pass just over $1 billion in funding for opioid treatment programs nationwide. This funding was included in the 21st Century Cures Act.
The Department of Justice has arrested and charged the founder and majority owner of Insys Therapeutics Inc., John Kapoor, along with other executives from his company. Kapoor is accused with leading a nationwide conspiracy to bribe doctors and illegally distribute the company's fentanyl spray, intended for cancer patients, so that it could be prescribed for non-cancer patients. Kapoor stepped down as CEO of Insys in January. Acting U.S. Attorney William D. Weinreb said, "Mr. Kapoor and his company stand accused of bribing doctors to overprescribe a potent opioid and committing fraud on insurance companies solely for profit. Today's arrest and charges reflect our ongoing efforts to attack the opioid crisis from all angles. We must hold the industry and its leadership accountable - just as we would the cartels or a street-level drug dealer." Six former Insys executives and managers were charged in December.
64% of Americans now support the legalization of cannabis, an all-time high since Gallup first asked the question in 1969. Also for the first time, a majority of Republicans (51%) support legalization, up from 42% last year:
As efforts to legalize marijuana at the state level continue to yield successes, public opinion, too, has shifted toward greater support. The Department of Justice under the current Republican administration has been perceived as hostile to state-level legalization. But Attorney General Jeff Sessions could find himself out of step with his own party if the current trends continue. Rank-and-file Republicans' views on the issue have evolved just as Democrats' and independents' have, though Republicans remain least likely to support legalizing pot.