Arthur T Knackerbracket has found the following story:
Drug-resistant bacteria responsible for deadly hospital-acquired infections shut out antibiotics by closing tiny doors in their cell walls.
The new finding by researchers at Imperial College London could allow researchers to design antibiotics into bacterial cells. The result is published today in Nature Communications.
The bacterium Klebsiella pneumoniae causes infections in the lungs, blood and wounds of those in hospitals, and patients that have compromised immune systems are especially vulnerable. More than 20,000 K. pneumoniae infections were recorded in UK hospitals in the past year.
Like many bacteria, K. pneumoniae is becoming increasingly resistant to antibiotics, particularly a family of drugs called Carbapenems. Carbapenems are used as antibiotics in hospitals when others have failed or are ineffective.
[...] Now, the team from Imperial has discovered one mechanism by which K. pneumoniae is able to resist Carbapenems. Antibiotics usually enter the K. pneumoniae bacteria through surface doorways known as pores. The team investigated the structure of the pores and showed that by shutting these doorways K. pneumoniae becomes resistant to multiple drugs, since antibiotics cannot enter and kill them.
[...] The closed doors aren't all good news for bacteria. They also mean that the bacteria can take in fewer nutrients, and tests in mice showed that the bacteria grow slower as a result.
However, the advantage in terms of avoiding antibiotics outweighed the negative impact of slower growth for the bacteria, allowing them to maintain a high level of infection.
Journal Article: (Open Access) Joshua L. C. Wong, Maria Romano, Louise E. Kerry; OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo Nature Communications, Vol. 10 Issue1. (2019)
(Score: 2, Funny) by Anonymous Coward on Thursday September 05 2019, @11:17AM
/* K. pneumoniae goes to the door but doesn't open it
K. pneumoniae: "Who is it?"
Carbapenem: "Candygram."
K. pneumoniae: "They stopped that years ago."
Carbapenem: "Er, plumber."
K. pneumoniae: "I don't have any plumbing problems. You're Carbapenem, aren't you?"
Carbapenem: "um... Land shark."
K. pneumoniae: "Oh, a land shark! Come right on in..." /* opens door
/* Carbapenem enters and devours K. pneumoniae
(Score: 5, Interesting) by Azuma Hazuki on Thursday September 05 2019, @11:34AM (1 child)
I've been following this one for a while, and the two words in that order still give me chills. Carbapenems are antibiotics of last resort, and some are even given with molecules that inhibit or soak beta-lactamase (vaborbactam for example) specifically to shut down enzymatic resistance. If these little bugs have decided to go a physical rather than chemical route, that won't help.
If it were up to me I'd be investigating phage therapy in cases like this, much as *that* scares me too. And we'd go back to red brass touch surfaces and giving things a good once over with carbolic soap, like the olden days.
I am "that girl" your mother warned you about...
(Score: 2, Informative) by Anonymous Coward on Thursday September 05 2019, @04:41PM
They are going back to brass and other copper containing metals.
Also physical structures like this:
https://phys.org/news/2018-06-bacteria-shark-skin-inspired-surfaces.html [phys.org]
(Score: 0) by Anonymous Coward on Thursday September 05 2019, @01:41PM
Almost every article that claims researchers have now 'revealed' something as if it's something we didn't know from before is almost always wrong. I kinda get tired of this.
From wikipedia
Reduced drug accumulation: by decreasing drug permeability or increasing active efflux (pumping out) of the drugs across the cell surface
https://en.wikipedia.org/wiki/Antimicrobial_resistance#Bacteria [wikipedia.org]
Articles should be careful to not present a specific research point as being new and cutting edge when it's something that's already well known. Perhaps you can say there has been an increase in bacteria that have been gaining immunity this way or an increase of a specific type of bacteria that has been gaining immunity this way. Be specific about what's new in this article and don't claim something that's old and well known as being newly discovered information.