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Protein Associated With Many Diseases Fully Visualized For First Time

posted by Fnord666 on Monday October 07 2019, @02:37AM   Printer-friendly
from the can-you-see-it-now? dept.
Science

Arthur T Knackerbracket has found the following story:

For the first time, researchers have observed at the molecular level how a protein associated with numerous health problems works.

Steven Mansoor, M.D., Ph.D., and colleagues have identified the inner workings of the P2X7 protein receptor, which is associated with inflammation, coronary artery disease, cancer, multiple sclerosis and more.

The discovery - which could one day inspire new drugs to treat inflammation, coronary artery disease, cancer, multiple sclerosis and more - was published today in the journal Cell.

Oregon Health & Science University research assistant Alanna McCarthy, B.S., and OHSU researcher Steven Mansoor, M.D., Ph.D., used cryoelectron microscopy to obtain the 3D structure of a protein receptor and observe its inner workings. The protein receptor they studied is a cellular membrane protein that allows electrically charged sodium and calcium particles to enter and trigger changes in a cell.

They specifically studied the P2X7 receptor, a subtype of the ligand-gated ion channel P2X family that has been associated with inflammation, plaque buildup in arteries, cancer metastasis, neurological conditions and more.

REFERENCE: Alanna E. McCarthy, Craig Yoshioka, Steven E. Mansoor, Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization[$], Cell, 11 a.m. ET Oct. 3, 2019, DOI: 10.1016/j.cell.2019.09.017.

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  • (Score: -1, Spam) by Anonymous Coward on Monday October 07 2019, @03:11AM (1 child)

    by Anonymous Coward on Monday October 07 2019, @03:11AM (#903562)

    Nigger sperm is full of P2X7 which is why your vagina swells shut to keep the sperm of other niggers out. Also P2X7 is why you die of colon cancer if a nigger ejaculates up your ass instead.

    • (Score: -1, Spam) by Anonymous Coward on Monday October 07 2019, @03:24AM

      by Anonymous Coward on Monday October 07 2019, @03:24AM (#903571)

      You can't handle the nigger sperm! Seriously wash your hands.

  • (Score: 0, Disagree) by Anonymous Coward on Monday October 07 2019, @03:34AM (2 children)

    by Anonymous Coward on Monday October 07 2019, @03:34AM (#903574)

    What is it with the random studies that get coverage here? Is someone paying to get press so they get more cites?

    • (Score: 1, Funny) by Anonymous Coward on Monday October 07 2019, @03:53AM (1 child)

      by Anonymous Coward on Monday October 07 2019, @03:53AM (#903579)

      Arthur T Knackerbracket is a bot. Tell the cocksuckers who run that thing to point their bot at hot celebrity news instead. SN needs less science and more tits.

      • (Score: 0) by Anonymous Coward on Monday October 07 2019, @10:32AM

        by Anonymous Coward on Monday October 07 2019, @10:32AM (#903652)

        SN needs less science and more tits.

        Moar man-boobs, TMB likes em 2.

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