from the Not-sure-whether-to-feel-happy-or-sad-about-this dept.
Blood Test Developed to Detect Depression and Bipolar Disorder:
While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.
Led by Alexander B. Niculescu, MD, PhD, Professor of Psychiatry at IU School of Medicine, the study was published today (April 8, 2021) in the high impact journal Molecular Psychiatry. The work builds on previous research conducted by Niculescu and his colleagues into blood biomarkers that track suicidality as well as pain, post-traumatic stress disorder, and Alzheimer's disease.
"We have pioneered the area of precision medicine in psychiatry over the last two decades, particularly over the last 10 years. This study represents a current state-of-the-art outcome of our efforts," said Niculescu. "This is part of our effort to bring psychiatry from the 19th century into the 21st century. To help it become like other contemporary fields such as oncology. Ultimately, the mission is to save and improve lives."
The team's work describes the development of a blood test, composed of RNA biomarkers, that can distinguish how severe a patient's depression is, the risk of them developing severe depression in the future, and the risk of future bipolar disorder (manic-depressive illness). The test also informs tailored medication choices for patients.
[...] In addition to the diagnostic and therapeutic advances discovered in their latest study, Niculescu's team found that mood disorders are underlined by circadian clock genes — the genes that regulate seasonal, day-night and sleep-wake cycles.
"That explains why some patients get worse with seasonal changes, and the sleep alterations that occur in mood disorders," said Niculescu.
Journal Reference:
H. Le-Niculescu, K. Roseberry, S. S. Gill, et al. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs [open], Molecular Psychiatry (DOI: 10.1038/s41380-021-01061-w)
(Score: 1, Flamebait) by HammeredGlass on Thursday April 08 2021, @11:03PM (3 children)
The track record of the softest science is not great.
(Score: 2) by sjames on Friday April 09 2021, @01:50AM
Of course, a big part of the problem was a lack of objectively testable biological markers for depression. Now there is one. Replication, as always, is needed.
(Score: 3, Touché) by Beryllium Sphere (r) on Friday April 09 2021, @02:09AM
The footnotes include other researchers with parallel findings. Where do you see that falling short?
(Score: 0) by Anonymous Coward on Friday April 09 2021, @02:11AM
In my experience, liquor bottles tend to be on the hard side.
(Score: -1, Troll) by Ethanol-fueled on Thursday April 08 2021, @11:05PM (13 children)
More Bolshevik psychiatry, written in such a way so as to sell Jewish drugs and other Jewish solutions to people. I wonder if they will "isolate the markers" that indicate a presence of Jewish psychopathy or other "ethnic" predispositions to crime.
When it comes to genes and biomarkers, you can't have your cake and eat it too. Assuming what is described in TFA is actually legitimate science and not just a "scientific" sales pitch, what other unflattering "mood ailments" could be discovered by examining genes and genetic markers? I can already smell the Jews preparing this for after the public tires of their race-baiting, hoax lockdowns, and climate change scaremongering. The Jews will go full-circle into Nazi-style eugenics after their other options are exhausted, but thanks to their current infiltration of government, it is considered anti-Semitism according to the State Department definition for others to accuse Jews of acts associated with Nazis.
(Score: -1, Offtopic) by Anonymous Coward on Thursday April 08 2021, @11:12PM (2 children)
I predict that they will identify the genetic marker for transgenderism within five years and have a pharmaceutical cure ready soon thereafter.
(Score: -1, Offtopic) by Ethanol-fueled on Thursday April 08 2021, @11:32PM (1 child)
Be careful what you wish for. Who would maintain the Rust programming language? The Linux kernel? Who would make video games? Who would make sure that CIS White supremacists couldn't post on Reddit? What would Christian men do without their transgender hookers* ?
* If they wanted to bang actual women they'd bang their wives instead.
(Score: 0) by Anonymous Coward on Friday April 09 2021, @09:33PM
(Score: -1, Offtopic) by Anonymous Coward on Thursday April 08 2021, @11:40PM
No test necessary for you E-f. Your psychology is well-known and your case hopeless.
At the risk of feeding a troll, I would point out that it would be history repeating itself. Look up the Martyrs of Najran. The seed they planted there returned seven hundred fold in Nazi Germany.
--
Those who will not learn from history...
(Score: 0, Interesting) by Anonymous Coward on Thursday April 08 2021, @11:40PM
What we need are elective lobotomies. Just make it so I don't feel anything anymore. The post Camelot world really sucks
(Score: 1, Offtopic) by Azuma Hazuki on Friday April 09 2021, @12:02AM (6 children)
Sounds to me like you're aware of what a disaster your own genome (and life...!) is on some level.
You know, you've always been a sandy little butthole, but the last couple of months or so you've really ramped up the insanity factor. What happened, did you get fired for getting caught spitting in the McNugget bin one too many times or something?
I am "that girl" your mother warned you about...
(Score: -1, Offtopic) by Anonymous Coward on Friday April 09 2021, @01:42AM (2 children)
His genetic stock is a solid combination of Jewish and Mexican bloodlines.
His insanity is acquired.
(Score: -1, Offtopic) by Anonymous Coward on Friday April 09 2021, @02:02AM (1 child)
Then why do pasty christians of west european descent have the highest rates of mental illness? One of the crazier sects of the Jesus hypicrites even has an abnormally high rate of schizophrenia!
(Score: 0) by Anonymous Coward on Saturday April 10 2021, @01:50AM
Introspection is the curse of The Great Intelligence Burden... don't worry, you're immune.
(Score: 0) by Anonymous Coward on Saturday April 10 2021, @02:04AM (2 children)
Having ones own ideas is a great thing, but you should really try learning from the ideas of others.
You're still under the delusion that peppering your writing with the seven words you can't say on television, is a positive thing.
(Score: 2) by Azuma Hazuki on Saturday April 10 2021, @12:16PM (1 child)
Ah, I miss Carlin...but tell me, why is using them a bad thing? They have their place.
I am "that girl" your mother warned you about...
(Score: 0) by Anonymous Coward on Sunday April 11 2021, @02:27AM
I have some ideas about this subject.
(Score: 3, Touché) by krishnoid on Friday April 09 2021, @12:06AM
As researched and published by that bastion of Bolshevism ... Indiana University.
(Score: 0, Funny) by Anonymous Coward on Thursday April 08 2021, @11:18PM (6 children)
You can usually tell just by looking if someone is depressed, and by looking twice if they're bipolar.
(Score: 0) by Anonymous Coward on Thursday April 08 2021, @11:42PM
Yeah, I was really excited about this, and then suddenly I wasn't anymore.
(Score: 5, Informative) by Immerman on Friday April 09 2021, @01:14AM (4 children)
Not hardly. You want to tell me you knew Robin Williams was depressed for decades before his death?
Depressed people usually go out of their way to pretend to be fine. As a rule other people are singularly unhelpful, even hurtful, if they know you're depressed. From empty platitudes and unhelpful advice, to chastisement to "pull yourself together", to outright avoiding you because you're a downer. Nothing good comes from publicly admitting to depression. If you meet somebody who is obviously depressed, it's a good bet they're already so far gone they can't even be bothered to try to avoid the fresh barbs anymore.
Or possibly they're goth - that tends to look a lot like depression to many people who don't understand it.
(Score: 3, Interesting) by Arik on Friday April 09 2021, @02:27AM (3 children)
Most of my life I was mostly manic. People thought I was depressed when I was completely the opposite. They were so annoying.
Now I'm depressed. Everyone thinks I'm manic. I've learned. Act peppy and friendly! That way you get out of there more quickly.
<whispers>Why are you such a stupid asshole? Would you really like to know? Well, pay your fee, remove your clothes, and Yvette will show you how; You went to school where you were taught to fear and to obey, be cheerful, fit in, or someone might think you're weird. Life can be perfect. People can be trusted. Someday, I will fall in love; a nice quiet home of my very own. Free from all the pain. Happy and having fun all the time. It never happened, did it?</whispers>
People don't have a clue.
This might be a step forward. Or a step backward. Hard to tell from a pop-sci blurb. Sounds like they did the 21st century thing - generated a bunch of numbers, threw them at a computer and told it to find correlations.
Correlation is not causation. But closely inspecting correlations sometimes elucidates correlation.
If laughter is the best medicine, who are the best doctors?
(Score: 2) by Immerman on Friday April 09 2021, @01:41PM (1 child)
Sounds like they don't actually care about causation at this point - a high degree of correlation is all that's needed for a powerful diagnostic tool.
Now, if they can determine a causal chain, perhaps this might lead to a depression treatment that attacks the root of the problem, rather than just mitigating the symptoms. But even if they never do, *if* their results are accurate and they've developed a blood test that can say "This person is suffering from Class 3 depression", that could save a whole lot of headaches for people trying hard to care enough to get treatment.
(Score: 2) by Arik on Wednesday April 14 2021, @02:35AM
High church scientism in a nutshell.
See they're correlating one thing they don't understand with another thing they don't understand.
Odds are good they'll misunderstand the correlation as well.
If laughter is the best medicine, who are the best doctors?
(Score: 0) by Anonymous Coward on Friday April 09 2021, @01:53PM
I'm guessing they not depressed because of the blood test... but there's me confusing correlation and causation.
(Score: -1, Offtopic) by Anonymous Coward on Friday April 09 2021, @12:00AM
https://archive.org/download/TerryADavis_TempleOS_Archive/videos/2017/2017-07-12T04:47:05+00:00%20-%2008JewishPig.MP4 [archive.org]
* TPTB want you to forget about TempleOS and the idea of "do it yourself" software, unless of course it's software THEY control! And the idea of "no networking" is peace of mind in the times of Internet of Things and everything connecting to the beast, I mean internet. Men in high and low places harassed this man and may have intentionally led to his death, in my opinion.
-------
Terry A. Davis: The Movie!
(Score: 3, Touché) by Runaway1956 on Friday April 09 2021, @01:25AM (2 children)
I was looking for some kinda link between this guy and C.S. Forester. He sure is blowing his own horn!
The question is, can his work be replicated? I think we're all quite tired of hearing about breakthroughs that break nothing more than the definition of science.
https://pubmed.ncbi.nlm.nih.gov/26159600/ [nih.gov]
“I have become friends with many school shooters” - Tampon Tim Walz
(Score: -1, Flamebait) by Anonymous Coward on Friday April 09 2021, @01:48AM
Not at your age and with the stuff you have available.
Genetics from where you stand can be carried in a single way - sexual reproduction. Too late for you Runaway.
(Score: 0) by Anonymous Coward on Friday April 09 2021, @01:55PM
> The question is....
Oh how smart you sound! Actually the question ls: who can be bothered+has funding+people to elevate this study by trying to replicate it.
(Score: 1) by js290 on Friday April 09 2021, @01:58AM
(Score: 2) by DannyB on Friday April 09 2021, @03:41PM
How about a blood or urine test to indicate if someone is crazy enough to program in Java?
It would simplify the interview process.
The server will be down for replacement of vacuum tubes, belts, worn parts and lubrication of gears and bearings.