Immune changes can cause peanut allergy remission:
The potential of new, more focused allergy treatments is now possible thanks to the identification of the key immunological changes that allow the remission of peanut allergy in children.
For the first time, researchers discovered that particular gene networks are rewired to drive the transition from peanut allergy to clinical remission after combination treatment of a probiotic and peanut oral immunotherapy.
The research, led by the Murdoch Children's Research Institute (MCRI) and the Telethon Kids Institute, discovered that network reprogramming effectively shuts down the allergic immune response that causes a food allergy. The study was published in the journal Allergy.
[...] 62 Melbourne-based children with peanut allergies, ages 1 to 10, participated in the randomized controlled experiment. They were either given a placebo or a probiotic treatment that included oral immunotherapy (the progressive introduction of the allergenic food). After 18 months of treatment, 74% of patients receiving the combo therapy had remission, compared to 4% of those receiving a placebo.
[...] "Certain changes in the allergen-specific immune cells, called Th2 cells, are critical to achieving lasting remission," she said. Th2 cells are essential for generating allergen-specific antibodies and the development of food allergies. We found that the Th2 signaling that drives allergy is 'turned off' in children in remission."
Food allergy is a global public health concern, affecting 10% of infants and 5-8% of children.
Telethon Kids Institute's Dr. Anya Jones said because there was no cure for food allergies, management relied on avoidance of the allergenic food, resulting in reduced quality of life.
"Understanding the complex immune processes that support remission will provide greater insight into key drivers of treatment success and potentially identify novel targets for more effective treatments that deliver long-term solutions for patients," she said.
[...] "This research will give a lot of hope to families who have children with a peanut allergy," she said. We hope other families can experience the same sense of comfort we now have with a child who can eat peanuts freely without fear of a reaction."
Journal Reference:
Sarah E. Ashley, Anya C. Jones, Denise Anderson, et al., Remission of peanut allergy is associated with rewiring of allergen-driven T helper 2-related gene networks, Allergy, 2022. DOI: 10.1111/all.15324
(Score: -1, Troll) by Anonymous Coward on Wednesday July 13 2022, @06:12AM (1 child)
Time to quit with the *AC Friendly*, because we all know you are no friend of ACs. Better to label all the other stories as *AC Hostile*, or even *Anti-Free-speech*. But that labelling is up to you. This is your show, your site, and your vendetta to stop aristarchus from ever posting again, as AC or otherwise. SoylentNews delenda est. Requiem in pacis.
(Score: -1, Offtopic) by Anonymous Coward on Wednesday July 13 2022, @07:43AM
Melville, Moby Dick, Chapter 132, The Symphony
(Score: 3, Interesting) by bradley13 on Wednesday July 13 2022, @06:28AM (5 children)
Back in the stone age, when I was in high school, I took an intensive summer course in health and medicine. One of the teachers told us a personal anecdote: as an adult, he developed allergies to both chocolate and dairy. Since he loved both, he made a point of eating chocolate ice cream daily, and let his body sort things out. After a few months, everything was fine again - his immune system came to terms with what it perceived as allergens.
My own anecdote: I am allergic to cats, but I like having cats. Whenever I get a new cat, all the classic symptoms are there. After a few weeks, my body learns to tolerate this particular cat. Not other cats - the allergies are, if anything, worse - but cats I am around every day are no problem.
So TFA: the trick is that peanut allergies are life threatening. However, if one can avoid killing the patient by accident, it is entirely believable that you can train the body's immune system to deal with the allergens.
Everyone is somebody else's weirdo.
(Score: -1, Troll) by Anonymous Coward on Wednesday July 13 2022, @06:34AM
So, you are saying, AC Hostile?
(Score: 0) by Anonymous Coward on Wednesday July 13 2022, @06:58AM
While it might work, I would be cautious though. I have a small food allergy for mint (since birth) and pure chocolate (developed later), but it manifests in sneezing. I never really thought about it as an allergy until someone pointed this out to me. For the mint I thought it was normal to sneeze with it. Thinking about it, while I like both, I also consume those things and the sympthoms have lessened over the years.
Another anacdote is about sweet pepper, breeders seem to develop a allergy against pepper pollen when they don't take precautions. When I worked with it, I was adviced to wear a mouth mask when handling the pollen.
(Score: 2) by crafoo on Wednesday July 13 2022, @07:54AM
happened to me with apples. so strange. one day they started making my throat swell nearly closed. so I just ate a bite a day for awhile. I can't remember exactly how long it took, but it took about a year for me.
yes I wash my apples. I thought it might be a pesticide too.
(Score: 4, Interesting) by FatPhil on Wednesday July 13 2022, @08:21AM (1 child)
Great minds discuss ideas; average minds discuss events; small minds discuss people; the smallest discuss themselves
(Score: 2) by optotronic on Thursday July 14 2022, @02:00AM
(Score: 2, Funny) by Opportunist on Wednesday July 13 2022, @06:54AM (2 children)
from the Peanut Gallery.
(Score: -1, Offtopic) by Anonymous Coward on Wednesday July 13 2022, @07:45AM (1 child)
No for long! Soon, very soon, they will all be banned! Banned! I tell you! No more sarcastic comments, or dark sarcasm in the Soylent! Hey, janrinok, leave those ACs alone!
(Score: 4, Funny) by inertnet on Wednesday July 13 2022, @09:00AM
In other news, they're still looking to cure single minded, inflammatory posters on the internet.
Tiny doses of reality have been tried unsuccessfully so far, the condition appears to worsen as a result.
(Score: 2, Troll) by Rosco P. Coltrane on Wednesday July 13 2022, @08:36AM
Isn't that what AIDS does?
There's your solution right there.
(Score: 0) by Anonymous Coward on Wednesday July 13 2022, @03:25PM (5 children)
Whenever I hear that one of my kid's friends has peanut allergies, I feed them a snack with some peanuts in it. Amazing how many of them have no problems with it, proving that peanut allergies are all in the mind of overprotective parents.
(Score: 3, Informative) by Freeman on Wednesday July 13 2022, @07:39PM (3 children)
That is beyond stupid. We feed our child a good variety of foods. Unfortunately, we found that they are allergic to 3 different nuts. So, we were like, okay, not too hard to keep them from eating those 3. Later, had a reaction for absolutely nothing that we could figure out. Except, that one of the food items said. "Produced in a facility that processes (One of the nuts they were allergic to)." We now, read every label and are somewhat paranoid, because No One Else will be. Please stop trying to "prove that you're right" by doing something that may cause the child to die. Especially, if heaven forbid, the parents forgot the EpiPen at home.
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: 2) by Freeman on Wednesday July 13 2022, @07:47PM
Don't get me wrong, there are treatments for some things. The difference is that they should be treatments that are deliberate and monitored. Not a random idiot believing they know best, because no one can be allergic to fresh fruits and veggies. Hint: Some People Are!
Joshua 1:9 "Be strong and of a good courage; be not afraid, neither be thou dismayed: for the Lord thy God is with thee"
(Score: -1, Troll) by Anonymous Coward on Wednesday July 13 2022, @07:52PM
They should put peanut oil in the drinking water supply to clean up the gene pool.
(Score: -1, Offtopic) by Anonymous Coward on Thursday July 14 2022, @12:15AM
》 we found that they are allergic to 3 different nuts
If you've already decided your child is non-binary, maybe you are one of the type of nuts that he or she is allergic to.
(Score: 0) by Anonymous Coward on Thursday July 14 2022, @01:48PM
STOP DOING THIS! Kids often outgrow allergies, but sometimes they don't. Depending on the severity, you could kill them!